Multiplex stress resistance in cells from long-lived dwarf mice
Open accessAbstract
Mutations that extend nematode longevity by interference with IGF‐I/insulin sensing pathways also lead to resistance to multiple forms of stress. Here, we report that skin‐derived fibroblasts from Snell dwarf mice, already known to show increased longevity and delayed aspects of aging, are resistant to multiple forms of cellular stress, including UV light, heat, paraquat, H 2 O 2 , and the toxic metal cadmium. The findings suggest that increases in cellular resistance to stress may mediate extended longevity in mammals.
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Impaired insulin/IGF-1 signaling lowers the oxidative burden and associated oxidative damage in cells, which contributes to increased longevity.
“Impaired insulin/IGF-1 signaling lowers the oxidative burden and the associated oxidative damage in cells which contributes to increased longevity”
From Redox control of senescence and age-related disease. (2017) · cites this paper as [150]
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References 13 · Cited by 207
- Authors
- Murakami, S., Salmon, A., & Miller, R. A.
- Affiliations
- University of Michigan (US)
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2003-06-03
- Volume
- 17
- Issue
- 11
- Pages
- 1565-1576
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2036288584
- Cited by
- 207
- References
- 13
- Citations by year
- 2025: 1 · 2024: 8 · 2023: 2 · 2022: 4 · 2021: 7 · 2020: 7 · 2019: 7 · 2018: 5 · 2017: 3 · 2016: 10 · 2015: 10 · 2014: 8 · 2013: 6 · 2012: 11
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Funders
- Norges Idrettshøgskole (P30-AG08808, T32-GM07315-21, T32-AG00114)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- stress tolerance, Snell dwarf mice, longevity, aging, dermal fibroblasts, UV resistance, heat stress, paraquat, hydrogen peroxide, cadmium toxicity, cellular stress
- MeSH terms
- Animals, Cadmium, Dwarfism, Fibroblasts, Hot Temperature, Hydrogen Peroxide, Lethal Dose 50, Longevity, Mice, Mutant Strains, Models, Biological, Paraquat, Ultraviolet Rays, Mice
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