The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The enigmatic protein kinase Cδ: complex roles in cell proliferation and survival
Abstract
Protein kinase Cδ (PKCδ) has been implicated both as a tumor suppressor and a positive regulator of cell cycle progression. PKCδ has also been reported to positively and negatively regulate apoptotic programs. This has led to conflicting hypotheses on the role of PKCδ in the control of cell proliferation and survival. Surprisingly PKCδ mice develop normally and are fertile indicating that PKCδ is not critical for normal cell proliferation during development. However PKCδ may play important roles in neoplastic cell proliferation. In this review we have summarized the apparent multifunctional properties of this enigmatic protein with regard to its role in the regulation of cell cycle progression and cell survival. It is proposed that PKCδ has both tumor suppressor and proliferation capabilities that can be recruited as a backup kinase for both gatekeeper tumor suppression and as an activator of the Ras/Raf/MEK/MAP kinase signaling pathway in cell proliferation.—Jackson D. N. Foster D. A. The enigmatic protein kinase Cδ: complex roles in cell proliferation and survival.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804
Protein kinase C as a possible receptor protein of tumor‐promoting phorbol esters
Kikkawa, U., Takai, Y., Tanaka, Y., Miyake, R., & Nishizuka, Y. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44245-1 · Cited by 881
Cited by
Protein kinase C and other diacylglycerol effectors in cancer
Griner, E. M., & Kazanietz, M. G. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2110 · Cited by 978
Redox Homeostasis and Cellular Antioxidant Systems: Crucial Players in Cancer Growth and Therapy
Marengo, B., Nitti, M., Furfaro, A. L., Colla, R., Ciucis, C. D., Marinari, U. M., Pronzato, M. A., Traverso, N., & Domenicotti, C. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/6235641 · Cited by 319
Gorter, J. A., van Vliet, E. A., Aronica, E., Breit, T., Rauwerda, H., Lopes da Silva, F. H., & Wadman, W. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2766-06.2006 · Cited by 316
Protein kinase C isoforms: Multi-functional regulators of cell life and death
Reyland, M. (2009) · Frontiers in Bioscience · doi:10.2741/3385 · Cited by 266
The protein kinase C (PKC) family of proteins in cytokine signaling in hematopoiesis
Redig, A. J., & Platanias, L. C. (2007) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2007.0007 · Cited by 51
Metadata
- Authors
- Jackson, D. N., & Foster, D. A.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2004-04
- Volume
- 18
- Issue
- 6
- Pages
- 627-636
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2058983867
- Cited by
- 195
- References
- 3
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The enigmatic protein kinase Cδ: complex roles in cell proliferation and survival. https://app.cochat.ai/papers/10.1096/fj.03-0979rev
- The paper
- Jackson, D. N., & Foster, D. A. (2004). The enigmatic protein kinase Cδ: complex roles in cell proliferation and survival. The FASEB Journal. https://doi.org/10.1096/fj.03-0979rev
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
