The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition
Open accessAbstract
Vimentin is used widely as a marker of the epithelial to mesenchymal transitions (EMTs) that take place during embryogenesis and metastasis, yet the functional implications of the expression of this type III intermediate filament (IF) protein are poorly understood. Using form factor analysis and quantitative Western blotting of normal, metastatic, and vimentin‐null cell lines, we show that the level of expression of vimentin IFs (VIFs) correlates with mesenchymal cell shape and motile behavior. The reorganization of VIFs caused by expressing a dominant‐negative mutant or by silencing vimentin with shRNA (neither of which alter microtubule or microfilament assembly) causes mesenchymal cells to adopt epithelial shapes. Following the microinjection of vimentin or transfection with vimentin cDNA, epithelial cells rapidly adopt mesenchymal shapes coincident with VIF assembly. These shape transitions are accompanied by a loss of desmosomal contacts, an increase in cell motility, and a significant increase in focal adhesion dynamics. Our results demonstrate that VIFs play a predominant role in the changes in shape, adhesion, and motility that occur during the EMT.—Mendez, M. G., Kojima, S.‐I., Goldman, R. D. Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition. FASEB J. 24, 1838–1851 (2010). www.fasebj.org
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Cites
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Molecular mechanisms of epithelial–mesenchymal transition
Lamouille, S., Xu, J., & Derynck, R. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3758 · Cited by 8,091
Datta, A., Deng, S., Gopal, V., Yap, K. C.-H., Halim, C. E., Lye, M. L., Ong, M. S., Tan, T. Z., Sethi, G., Hooi, S. C., et al. (2021) · Cancers · doi:10.3390/cancers13081882 · Cited by 184
Vimentin filaments integrate low-complexity domains in a complex helical structure
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Self-citationLocalized EMT reprograms glial progenitors to promote spinal cord repair
Klatt Shaw, D., Saraswathy, V. M., Zhou, L., McAdow, A. R., Burris, B., Butka, E., Morris, S. A., Dietmann, S., & Mokalled, M. H. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.01.017 · Cited by 70
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Metadata
- Authors
- Mendez, M. G., Kojima, S., & Goldman, R. D.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2010-01-22
- Volume
- 24
- Issue
- 6
- Pages
- 1838-1851
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2126931729
- Cited by
- 939
- References
- 54
- FWCI
- 13.54
- Type
- journal article
- Language
- en
- Open access
- green
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