The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Sequenced response of extracellular matrix deadhesion and fibrotic regulators after muscle damage is involved in protection against future injury in human skeletal muscle
Open accessAbstract
The purpose of this study was to test the hypothesis that remodeling of skeletal muscle extracellular matrix (ECM) is involved in protecting human muscle against injury. Biopsies were obtained from medial gastrocnemius muscles after a single bout of electrical stimulation (B) or a repeated bout (RB) 30 d later, or 30 d after a single stimulation bout (RBc). A muscle biopsy was collected from the control leg for comparison with the stimulated leg. Satellite cell content, tenascin C, and muscle regeneration were assessed by immunohistochemistry; real‐time PCR was used to measure mRNA levels of collagens, laminins, heat‐shock proteins (HSPs), inflammation, and related growth factors. The large responses of HSPs, CCL2, and tenascin C detected 48 h after a single bout were attenuated in the RB trial, indicative of protection against injury. Satellite cell content and 12 target genes, including IGF‐1, were elevated 30 d after a single bout. Among those displaying the greatest difference vs. control muscle, ECM laminin‐β1 and collagen types I and III were elevated ~6‐ to 9‐fold ( P< 0.001). The findings indicate that the sequenced events of load‐induced early deadhesion and later strengthening of skeletal muscle ECM play a role in protecting human muscle against future injury.—Mackey, A. L., Brandstetter, S., Schjerling, P., Bojsen‐Moller, J., Qvortrup, K., Pedersen, M. M., Doessing, S. Kjaer, M., Magnus‐son, S. P., Langberg, H. Sequenced response of extracellular matrix deadhesion and fibrotic regulators after muscle damage is involved in protection against future injury in human skeletal muscle. FASEB J. 25, 1943‐1959 (2011). www.fasebj.org
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Miller, B. F., Olesen, J. L., Hansen, M., Døssing, S., Crameri, R. M., Welling, R. J., Langberg, H., Flyvbjerg, A., Kjaer, M., Babraj, J. A., et al. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.093690 · Cited by 610
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Chen, C.-C., & Lau, L. F. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.07.025 · Cited by 549
Niche Regulation of Muscle Satellite Cell Self-Renewal and Differentiation
Kuang, S., Gillespie, M. A., & Rudnicki, M. A. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2007.12.012 · Cited by 507
Crameri, R. M., Aagaard, P., Qvortrup, K., Langberg, H., Olesen, J., & Kjær, M. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.128827 · Cited by 319 · cited 3×
“Tenascin C, belonging to the matricellular class of ECM proteins (26), has been reported to demonstrate dramatic responses in skeletal muscle subjected to unaccustomed exercise (4, 27, 28) and indeed to be essential for full-scale muscle injury repair, providing deadhesive effects and potentially a coordinating role a…”
BackgroundSelf-citationMuscle fiber necrosis associated with human marathon runners
Hikida, R. S., Staron, R. S., Hagerman, F. C., Sherman, W. M., & Costill, D. L. (1983) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(83)90037-0 · Cited by 276
Bamman, M. M., Petrella, J. K., Kim, J.-S., Mayhew, D. L., & Cross, J. M. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00024.2007 · Cited by 216
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Halper, J., & Kjaer, M. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-94-007-7893-1_3 · Cited by 532
Self-citationControl of satellite cell function in muscle regeneration and its disruption in ageing
Sousa-Victor, P., García-Prat, L., & Muñoz-Cánoves, P. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00421-2 · Cited by 476
Csapo, R., Gumpenberger, M., & Wessner, B. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00253 · Cited by 429
Saclier, M., Yacoub-Youssef, H., Mackey, A. L., Arnold, L., Ardjoune, H., Magnan, M., Sailhan, F., Chelly, J., Pavlath, G. K., Mounier, R., et al. (2013) · Stem Cells · doi:10.1002/stem.1288 · Cited by 419
Self-citationDamas, F., Phillips, S. M., Libardi, C. A., Vechin, F. C., Lixandrão, M. E., Jannig, P. R., Costa, L. A. R., Bacurau, A. V., Snijders, T., Parise, G., et al. (2016) · The Journal of Physiology · doi:10.1113/jp272472 · Cited by 353
Metadata
- Authors
- Mackey, A. L., Brandstetter, S., Schjerling, P., Bojsen‐Moller, J., Qvortrup, K., Pedersen, M. M., Doessing, S., Kjaer, M., Magnusson, S. P., & Langberg, H.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2011-03-02
- Volume
- 25
- Issue
- 6
- Pages
- 1943-1959
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2115612732
- Cited by
- 170
- References
- 6
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Sequenced response of extracellular matrix deadhesion and fibrotic regulators after muscle damage is involved in protection against future injury in human skeletal muscle. https://app.cochat.ai/papers/10.1096/fj.10-176487
- The paper
- Mackey, A. L., Brandstetter, S., Schjerling, P., Bojsen‐Moller, J., Qvortrup, K., Pedersen, M. M., Doessing, S., Kjaer, M., Magnusson, S. P., & Langberg, H. (2011). Sequenced response of extracellular matrix deadhesion and fibrotic regulators after muscle damage is involved in protection against future injury in human skeletal muscle. The FASEB Journal. https://doi.org/10.1096/fj.10-176487
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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