Detrimental effects of constant light exposure and high-fat diet on circadian energy metabolism and insulin sensitivity
Abstract
Circadian rhythm disturbances are observed in, e.g. , aging and neurodegenerative diseases and are associated with an increased incidence of obesity and diabetes. We subjected male C57Bl/6J mice to constant light [12‐h light‐light (LL) cycle] to examine the effects of a disturbed circadian rhythm on energy metabolism and insulin sensitivity. In vivo electrophysiological recordings in the central pacemaker of the suprachiasmatic nuclei (SCN) revealed an immediate reduction in rhythm amplitude, stabilizing at 44% of normal amplitude values after 4 d LL. Food intake was increased (+26%) and energy expenditure decreased (–13%), and we observed immediate body weight gain (d 4: +2.4%, d 14: +5.0%). Mixed model analysis revealed that weight gain developed more rapidly in response to LL as compared to high fat. After 4 wk in LL, the circadian pattern in feeding and energy expenditure was completely lost, despite continuing low‐amplitude rhythms in the SCN and in behavior, whereas weight gain had stabilized. Hyperinsulinemic‐euglycemic clamp analysis revealed complete abolishment of normal circadian variation in insulin sensitivity in LL. In conclusion, a reduction in amplitude of the SCN, to values previously observed in aged mice, is sufficient to induce a complete loss of circadian rhythms in energy metabolism and insulin sensitivity.—Coomans, C. P., van den Berg, S. A. A., Houben, T., van Klinken, J.‐B., van den Berg, R., Pronk, A. C. M., Havekes, L. M., Romijn, J. A., Willems van Dijk, K., Biermasz, N. R., Meijer, J. H. Detrimental effects of constant light exposure and high‐fat diet on circadian energy metabolism and insulin sensitivity. FASEB J. 27, 1721–1732 (2013). www.fasebj.org
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A high-fat diet may alter the function of the circadian clock, with an altered period of the locomotor activity rhythm and changes in the rhythms of core clock genes in adipose and liver tissue.
“Even a high-fat diet may alter the function of the circadian clock, with an altered period of the locomotor activity rhythm and changes in the rhythms of the core clock genes in adipose and liver tissue [35–40,49].”
From Circadian control of glucose metabolism (2014) · cites this paper as [40]
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References 53 · Cited by 252
- Authors
- Coomans, C. P., van den Berg, S. A. A., Houben, T., van Klinken, J., van den Berg, R., Pronk, A. C. M., Havekes, L. M., Romijn, J. A., van Dijk, K. W., Biermasz, N. R., & Meijer, J. H.
- Affiliations
- Leiden University Medical Center (NL)
- Department of Human Genetics Leiden University Medical Center Leiden The Netherlands
- Netherlands Organisation for Applied Scientific Research (NL)
- Corresponding author
- Coomans, Claudia P.
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2013-01-09
- Volume
- 27
- Issue
- 4
- Pages
- 1721-1732
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W2106339147
- Cited by
- 252
- References
- 53
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 11 · 2023: 20 · 2022: 20 · 2021: 26 · 2020: 23 · 2019: 17 · 2018: 14 · 2017: 22 · 2016: 21 · 2015: 30 · 2014: 21 · 2013: 10
- FWCI
- 14.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The FASEB Journal (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- TNO Repository (submittedVersion)
- Repository hosted by TU Delft Library (TU Delft) (submittedVersion)
- Funders
- Top Institute Pharma (T2‐105)
- Diabetes Fonds (2007.00.010)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- continuous light exposure, circadian rhythm disruption, high-fat diet, insulin sensitivity, suprachiasmatic nucleus, rhythm amplitude, dietary intake, energy expenditure, weight gain, hyperinsulinemic-euglycemic clamp, obesity, diabetes mellitus
- MeSH terms
- Animals, Blood Glucose, Circadian Rhythm, Eating, Energy Metabolism, Insulin Resistance, Light, Male, Mice, Inbred C57BL, Obesity, Suprachiasmatic Nucleus, Mice, Diet, High-Fat
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