PRMT4 interacts with NCOA4 to inhibit ferritinophagy in cisplatin‐induced acute kidney injury
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Abstract
Cisplatin‐induced acute kidney injury (AKI) is commonly seen in the clinical practice, and ferroptosis, a type of non‐apoptotic cell death, plays a pivotal role in it. Previous studies suggested that protein arginine methyltransferase 4 (PRMT4) was incorporated in various bioprocesses, but its role in renal injuries has not been investigated. Our present study showed that PRMT4 was highly expressed in renal proximal tubular cells, and it was downregulated in cisplatin‐induced AKI. Besides, genetic disruption of PRMT4 exacerbated, while its overexpression attenuated, cisplatin‐induced redox injuries in renal proximal epithelia. Mechanistically, our work showed that PRMT4 interacted with NCOA4 to inhibit ferritinophagy, a type of selective autophagy favoring lipid peroxidation to accelerate ferroptosis. Taken together, our study demonstrated that PRMT4 interacted with NCOA4 to attenuate ferroptosis in cisplatin‐induced AKI, suggesting that PRMT4 might present as a new therapeutic target for cisplatin‐related nephropathy.
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Cites
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- Authors
- Zhou, L., Deng, Z., Wang, Y., Zhang, H., Yan, S., Kanwar, Y. S., Wang, Y., Dai, Y., & Deng, F.
- Affiliations
- Second Xiangya Hospital of Central South University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Guangzhou Women and Children Medical Center (CN)
- Northwestern University (US)
- Fifth Affiliated Hospital of Sun Yat-sen University (CN)
- Central South University (CN)
- Corresponding author
- Deng, Fei
- ORCID
- Venue
- The FASEB Journal
- Publisher
- Wiley
- Published
- 2024-04-03
- Volume
- 38
- Issue
- 7
- Pages
- e23584-e23584
- ISSN
- 0892-6638 (ISSN-L)
- 1530-6860
- OpenAlex
- W4393853610
- Cited by
- 16
- References
- 3
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 4
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- The FASEB Journal (publishedVersion)
- Research Square (acceptedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- China Postdoctoral Science Foundation (2021M693568)
- National Natural Science Foundation of China (82100733)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Chemotherapy-induced organ toxicity mitigation
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Ferroptosis and cancer prognosis
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Keywords
- PRMT4, NCOA4, ferritinophagy, ferroptosis, cisplatin-induced acute kidney injury, protein arginine methyltransferase, selective autophagy, lipid peroxidation, renal proximal tubular cells, therapeutic target
- MeSH terms
- Autophagy, Cisplatin, Humans, Kidney, Transcription Factors, Nuclear Receptor Coactivators, Acute Kidney Injury
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