The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Use of Antibodies to RCC and CD10 in the Differential Diagnosis of Renal Neoplasms
Abstract
The majority of renal neoplasms can be distinguished on the basis of histologic examination alone; however, there are morphologic similarities between clear cell renal carcinoma and chromophobe cell carcinoma, as well as between the granular/eosinophilic variants of these tumors and renal oncocytoma. Only a limited number of histochemical markers are available to aid in the differential diagnosis of these neoplasms. Hale's colloidal iron usually yields strong, diffuse cytoplasmic staining of chromophobe cell carcinomas whereas clear cell carcinomas are generally negative; however, interpretation of this stain is not always straightforward. By immunohistochemistry, vimentin is detectable in most clear cell carcinomas and is absent from most chromophobe cell tumors and oncocytomas, but reliance on a single antibody can be misleading. In this report we examine the use of commercially available monoclonal antibodies to RCC and CD10 in the differential diagnosis of common renal tumors. Eighty-five percent of clear cell carcinomas (53 of 62) had detectable surface membrane staining for RCC, and 94% (58 of 62) were positive for CD10. Papillary carcinomas were likewise strongly positive for RCC and CD10 in nearly all cases (13 of 14 each). In contrast, all 19 chromophobe cell carcinomas examined were completely negative for surface membrane staining with both of these markers. Oncocytomas were also negative for RCC (0 of 9), but CD10 was detectable in some cases (3 of 9). These results suggest that the presence of surface membrane staining for RCC and CD10 may be used to confirm a diagnosis of suspected clear cell or papillary renal carcinoma. Chromophobe cell carcinomas should be negative for both markers. The absence of RCC staining may also be helpful in the diagnosis of renal oncocytoma.
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Cites
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Renal Oncocytoma: A Reappraisal of Morphologic Features with Clinicopathologic Findings in 80 Cases
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Cited by
Amin, M. B., Epstein, J. I., Ulbright, T. M., Humphrey, P. A., Egevad, L., Montironi, R., Grignon, D., Trpkov, K., Lopez-Beltran, A., Zhou, M., et al. (2014) · American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000254 · Cited by 314
Clear Cell Papillary Renal Cell Carcinoma: A Distinct Histopathologic and Molecular Genetic Entity
Gobbo, S., Eble, J. N., Grignon, D. J., Martignoni, G., MacLennan, G. T., Shah, R. B., Zhang, S., Brunelli, M., & Cheng, L. (2008) · American Journal of Surgical Pathology · doi:10.1097/pas.0b013e318164bcbb · Cited by 272
Chu, P. G., Arber, D. A., Weiss, L. M., & Chang, K. L. (2001) · Modern Pathology · doi:10.1038/modpathol.3880335 · Cited by 271
Haque, M. E., Khan, F., Chi, L., Gurung, S., Vadevoo, S. M. P., Park, R.-W., Kim, D.-K., Kim, S. K., & Lee, B. (2019) · Cancer Research and Treatment · doi:10.4143/crt.2018.214 · Cited by 18
Metadata
- Authors
- Avery, A. K., Beckstead, J., Renshaw, A. A., & Corless, C. L.
- Venue
- The American Journal of Surgical Pathology
- Published
- 2000-02
- Volume
- 24
- Issue
- 2
- Pages
- 203-210
- ISSN
- 0147-5185 (ISSN-L)
- OpenAlex
- W2071597580
- Cited by
- 360
- References
- 16
- FWCI
- 10.59
- Type
- journal article
- Language
- en
- Open access
- closed
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