CoChat
Sign Up
Cited by 18

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Biotransformation of Halothane, Enflurane, Isoflurane, and Desflurane to Trifluoroacetylated Liver Proteins: Association Between Protein Acylation and Hepatic Injury

Njoku, Dolores, Laster, Michael J., Gong, Diane H., Eger, Edmond I, Reed, George F., Martin, Jackie L.·1997·Anesthesia & Analgesia
DOI 10.1097/00000539-199701000-00031
Open this paper in CoChat — free account

Abstract

In susceptible patients, halothane, enflurane, isoflurane, and desflurane can produce severe hepatic injury by an immune response directed against reactive anesthetic metabolites covalently bound to hepatic proteins. The incidence of hepatotoxicity appears to directly correlate with anesthetic metabolism catalyzed by cytochrome P450 2E1 to trifluoroacetylated hepatic proteins. In the present study, we examined whether the extent of acylation of hepatic proteins in rats by halothane, enflurane, isoflurane, and desflurane correlated with reported relative rates of metabolism. After pretreatment with the P450 2E1 inducer isoniazid, five groups of 10 rats breathed 1.25 minimum alveolar anesthetic concentration (MAC) of halothane, enflurane, isoflurane, or desflurane in oxygen, or oxygen alone, each for 8 h. Immunochemical analysis of livers harvested 18 h after anesthetic exposure showed tissue acylation (greatest to least) after exposure to halothane, enflurane, or isoflurane. Reactivity was not different between isoflurane as compared to desflurane or oxygen alone. An enzyme-linked immunosorbent assay showed halothane reactivity was significantly greater than that of enflurane, isoflurane, desflurane, or oxygen, and that enflurane reactivity was significantly greater than desflurane or oxygen. Sera from patients with a clinical diagnosis of halothane hepatitis showed antibody reactivity against hepatic proteins from rats exposed to halothane or enflurane. No reactivity was dete…

Overview

Integrity signals

Registry

Crossref · 10.1097/00000539-199701000-00031

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 24

  1. Wright, 1975, Lancet, 1, 817, 10.1016/S0140-6736(75)93000-7 · DOI
  2. Moult, 1975, Q J Med, 173, 99
  3. Warner, 1987, BMJ, 294, 1209, 10.1136/bmj.294.6581.1209 · DOI
  4. Neuberger, 1981, Gut, 22, 669, 10.1136/gut.22.8.669 · DOI
  5. Pohl, 1990, Adv Exp Med Biol, 283, 111, 10.1007/978-1-4684-5877-0_12 · DOI
  6. Dienstag, 1980, N Engl J Med, 303, 102, 10.1056/NEJM198007103030209 · DOI
  7. Kenna, 1988, J Pharmacol Exp Ther, 245, 1103
  8. Pohl, 1993, Chem Res Toxicol, 6, 786, 10.1021/tx00036a006 · DOI
  9. Pohl, 1989, Drug Metab Rev, 20, 203, 10.3109/03602538909103537 · DOI
  10. Cohen, 1975, Anesthesiology, 43, 392, 10.1097/00000542-197510000-00004 · DOI
  11. Chase, 1971, Anesthesiology, 35, 262, 10.1097/00000542-197109000-00007 · DOI
  12. Holaday, 1975, Anesthesiology, 43, 325, 10.1097/00000542-197509000-00009 · DOI
  13. Carey, 1972, Anesth Analg, 51, 135
  14. Lewis, 1983, Ann Intern Med, 98, 984, 10.7326/0003-4819-98-6-984 · DOI
  15. Eger, 1986, Anesth Analg, 65, 21, 10.1213/00000539-198601000-00004 · DOI
  16. Carrigan, 1987, Anesthesiology, 67, 581, 10.1097/00000542-198710000-00026 · DOI
  17. Martin, 1995, Anesthesiology, 83, 1125, 10.1097/00000542-199511000-00030 · DOI
  18. Satoh, 1985, J Pharmacol Exp Ther, 233, 857
  19. Martin, 1990, Anesth Analg, 70, 154, 10.1213/00000539-199002000-00004 · DOI
  20. Gut, 1993, Pharmacol Ther, 58, 133, 10.1016/0163-7258(93)90047-H · DOI
  21. Christ, 1988, Anesthesiology, 69, 833, 10.1097/00000542-198812000-00006 · DOI
  22. Martin, 1992, Anesth Analg, 74, 605
  23. Kenna, 1987, BMJ, 294, 1209, 10.1136/bmj.294.6581.1209 · DOI
  24. Bourdi, 1995, Arch Biochem Biophys, 323, 397, 10.1006/abbi.1995.0060 · DOI

Cited by

Sorted by citations

See all 18

Metadata

Authors
Njoku, D., Laster, M. J., Gong, D. H., Eger, E. I., Reed, G. F., & Martin, J. L.
Venue
Anesthesia & Analgesia
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1997-01
Volume
84
Issue
1
Pages
173-178
ISSN
0003-2999
DOI
10.1097/00000539-199701000-00031
Cited by
18
References
1
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review