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Cited by 346Anesthesia and Sedative AgentsBiomedical and Chemical ResearchAnesthesia and Pain Management

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Age, Minimum Alveolar Anesthetic Concentration, and Minimum Alveolar Anesthetic Concentration-Awake

Eger, Edmond I·2001·Anesthesia & Analgesia
DOI 10.1097/00000539-200110000-00029
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Abstract

UNLABELLED: Two defining effects of inhaled anesthetics (immobility in the face of noxious stimulation, and absence of memory) correlate with the end-tidal concentrations of the anesthetics. Such defining effects are characterized as MAC (the concentration producing immobility in 50% of patients subjected to a noxious stimulus) and MAC-Awake (the concentration suppressing appropriate response to command in 50% of patients; memory is usually lost at MAC-Awake). If the concentrations are monitored and corrected for the effects of age and temperature, the concentrations may be displayed as multiples of MAC for a standard age, usually 40 yr. This article provides an algorithm that might be used to produce such a display, including provision of an estimate of the effect of nitrous oxide. IMPLICATIONS: Two defining effects of inhaled anesthetics (immobility in the face of noxious stimulation, and absence of memory) correlate with the end-tidal concentrations of the anesthetics. Thus, these defining effects may be monitored and the results displayed if the concentrations are known and corrected for the effects of age and temperature.

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Research works printed but not linked: 63

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Metadata

Authors
Eger, E. I.
Affiliations
University of California, San Francisco (US)
Corresponding author
Eger, Edmond I
Venue
Anesthesia & Analgesia
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2001-10
Volume
93
Issue
4
Pages
947-953
ISSN
0003-2999 (ISSN-L)
DOI
10.1097/00000539-200110000-00029
OpenAlex
W1976810156
Cited by
346
References
0
Citations by year
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FWCI
3.34
Type
journal article
Language
en
Open access
closed
Locations
  • Anesthesia & Analgesia (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of General Medical Sciences (P01GM047818, 1P01GM47818-04)
Topics
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Sedative Agents
  • Health Sciences › Medicine › Physiology (medical) › Biomedical and Chemical Research
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Pain Management
Keywords
minimum alveolar concentration, age correction, inhalational anesthetics, end-tidal anesthetic concentration, immobility, memory loss, nitrous oxide, temperature correction, depth of anesthesia monitoring
MeSH terms
Aging, Anesthesia, Inhalation, Humans, Pulmonary Alveoli, Anesthetics, Inhalation

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