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Identification of Cytochrome P450 2E1 as the Predominant Enzyme Catalyzing Human Liver Microsomal Defluorination of Sevoflurane, Isoflurane, and Methoxyflurane
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“P450 2E1 from human livers exhibited oxidative defluorination activity on fluorinated inhalation anesthetics (e.g., sevoflurane, isoflurane, and methoxyflurane), resulting in the generation of toxic metabolic intermediates (116, 117).”
From Toward the development of a molecular toolkit for the microbial remediation of per-and polyfluoroalkyl substances (2024) · cites this paper as [116]
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Research works printed but not linked: 1
- [40]40. Berman ML, Holaday DA: Inhalation anesthetic metabolism and toxicity, Clinical Anesthesia. Edited by Barash PG, Cullen BF, Stoelting RK. New York, JB Lippincott, 1989, pp 323–338
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Assessment of specificity of eight chemical inhibitors using cDNA-expressed cytochromes P450
Sai, Y., Dai, R., Yang, T. J., Krausz, K. W., Gonzalez, F. J., Gelboin, H. V., & Shou, M. (2000) · Xenobiotica · doi:10.1080/004982500237541 · Cited by 138
Esposito, S., Deventer, K., Dumoulin, M., & Van Eenoo, P. (2012) · Drug Testing and Analysis · doi:10.1002/dta.1418 · Cited by 133
Hu, M., & Scott, C. (2024) · Applied and Environmental Microbiology · doi:10.1128/aem.00157-24 · Cited by 63
Metabolism of Chloroform in the Human Liver and Identification of the Competent P450s
Gemma, S., Vittozzi, L., & Testai, E. (2003) · Drug Metabolism and Disposition · doi:10.1124/dmd.31.3.266 · Cited by 60
Metadata
- Authors
- Kharasch, E. D., & Thummel, K. E.
- Affiliations
- ’ Associate Professor of Anesthesiology; Adjunct Associate Professor of Medicinal Chemistry
- Assistant Professor of Pharmaceutics.
- Venue
- Anesthesiology
- Published
- 1993-10-01
- Volume
- 79
- Issue
- 4
- Pages
- 795-807
- ISSN
- 0003-3022
- Cited by
- 232
- References
- 0
- Language
- en
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