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Sclerosing Cholangitis after Continuous Hepatic Artery Infusiori of FUDR
Open accessAbstract
Eight of 46 (17.4%) patients treated in our trial of continuous hepatic artery infusion (CHAI) of fluorodeoxyuridine (FUDR) by Infusaid pump developed biliary strictures. The lesions were clinically, radiographically, and pathologically identical to the idiopathic sclerosing cholangitis frequently seen in association with inflammatory bowel disease. Treatment included immediate cessation of intraarterial FUDR, and surgical or percutaneous drainage of the biliary tree if it was dilated. Two of the eight patients died of the complication. Three patients stabilized after biliary system drainage, and two patients improved on observation only. The pathogenesis of this complication is not understood. This report details the clinical and pathological features of this entity.
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Cited by
Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastases
Zorzi, D., Laurent, A., Pawlik, T. M., Lauwers, G. Y., Vauthey, J.-N., & Abdalla, E. K. (2007) · British Journal of Surgery · doi:10.1002/bjs.5719 · Cited by 532
Pathologic Features and Evolution of Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis
Scheuer, P. J. (1998) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(11)63652-5 · Cited by 106
Etiology and pathogenesis in primary sclerosing cholangitis
Boberg, K. M., Lundin, K. E. A., & Schrumpf, E. (1994) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529409103625 · Cited by 53
Metadata
- Authors
- KEMENY, M. M., BATTIFORA, H., BLAYNEY, D. W., CECCHI, G., GOLDBERG, D. A., LEONG, L. A., MARGOLIN, K. A., & TERZ, J. J.
- Venue
- Annals of Surgery
- Published
- 1985-08
- Volume
- 202
- Issue
- 2
- Pages
- 176-181
- ISSN
- 0003-4932 (ISSN-L)
- OpenAlex
- W2036509953
- Cited by
- 159
- References
- 0
- FWCI
- 9.01
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Sclerosing Cholangitis after Continuous Hepatic Artery Infusiori of FUDR. https://app.cochat.ai/papers/10.1097/00000658-198508000-00007
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- KEMENY, M. M., BATTIFORA, H., BLAYNEY, D. W., CECCHI, G., GOLDBERG, D. A., LEONG, L. A., MARGOLIN, K. A., & TERZ, J. J. (1985). Sclerosing Cholangitis after Continuous Hepatic Artery Infusiori of FUDR. Annals of Surgery. https://doi.org/10.1097/00000658-198508000-00007
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