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Prophylactic Platelet Administration During Massive Transfusion: A Prospective, Randomized, Double-Blind Clinical Study
Open accessAbstract
Prior studies at Harborview Medical Center have suggested that dilutional thrombocytopenia is a major etiology of microvascular, nonmechanical bleeding (MVB). We undertook a prospective randomized double-blind clinical study to compare the prophylactic effects of 6 units of platelet concentrates (PLT) versus 2 units of fresh frozen plasma (FFP) administered with every 12 units of modified whole blood in patients undergoing massive transfusion (12 or more units in 12 hours). After exclusions, three of 17 patients who received PLT and three of 16 patients who received FFP developed MVB, an incidence no different from our previous findings. Regression lines of platelet counts during transfusion were no different between groups, and both groups had higher platelet counts than predicted from a standard washout equation. Only one patient had evidence of dilutional thrombocytopenia as a cause for MVB. Prophylactic platelet administration is not warranted as a routine measure to prevent MVB.
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Cited by
Pathophysiology and Treatment of Coagulopathy in Massive Hemorrhage and Hemodilution
Bolliger, D., Görlinger, K., Tanaka, K. A., & Warner, D. S. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181f22b5a · Cited by 325
Practice Parameter for the Use of Fresh-Frozen Plasma, Cryoprecipitate, and Platelets
Cooper, E. S. (1994) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1994.03510340067036 · Cited by 295
Coagulopathy and blood component transfusion in trauma
Spahn, D. R., & Rossaint, R. (2005) · British Journal of Anaesthesia · doi:10.1093/bja/aei169 · Cited by 294
Metadata
- Authors
- REED, R. L., HEIMBACH, D. M., COUNTS, R. B., CIAVARELLA, D., BARON, L., CARRICO, C. J., & PAVLIN, E.
- Venue
- Annals of Surgery
- Published
- 1986-01
- Volume
- 203
- Issue
- 1
- Pages
- 40-48
- ISSN
- 0003-4932 (ISSN-L)
- OpenAlex
- W2039846470
- Cited by
- 226
- References
- 0
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Prophylactic Platelet Administration During Massive Transfusion: A Prospective, Randomized, Double-Blind Clinical Study. https://app.cochat.ai/papers/10.1097/00000658-198601000-00008
- The paper
- REED, R. L., HEIMBACH, D. M., COUNTS, R. B., CIAVARELLA, D., BARON, L., CARRICO, C. J., & PAVLIN, E. (1986). Prophylactic Platelet Administration During Massive Transfusion: A Prospective, Randomized, Double-Blind Clinical Study. Annals of Surgery. https://doi.org/10.1097/00000658-198601000-00008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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