Cited by 359Inflammatory mediators and NSAID effectsColorectal Cancer Screening and DetectionColorectal Cancer Treatments and Studies

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Reduced Risk of Colorectal Cancer among Long-Term Users of Aspirin and Nonaspirin Nonsteroidal Antiinflammatory Drugs

García Rodríguez, Luis A., Huerta-Alvarez, Consuelo·2001·Epidemiology

DOI 10.1097/00001648-200101000-00015

Open this paper in CoChat — free account

Abstract

Use of nonsteroidal antiinflammatory drugs (NSAIDs) has been associated with a reduced risk of colorectal cancer, but limited information is available on the effect of individual nonaspirin NSAIDs. In addition, the dose-response relation of aspirin in reducing the risk of colorectal cancer has not been described. We carried out a population-based cohort study with secondary case-control analysis to determine the association between the risk of colorectal cancer and use of aspirin and individual NSAIDs, including the role of dose and duration. The General Practice Research Database in the U.K. was the source population. We traced 943,903 persons 40-79 years of age and free of cancer and colorectal adenoma between January 1994 and September 1997. A total of 2,002 incident cases of colorectal cancer were ascertained. The incidence rate of colorectal cancer per 10,000 person-years was 7.3. The risk of colorectal cancer was reduced in users of nonaspirin NSAIDs and became evident after 6 months of continuous treatment. The adjusted relative risk was 0.5 (95% confidence interval = 0.4-0.7). The reduction in risk disappeared completely 1 year after stopping NSAID treatment. The risk of developing colorectal cancer was reduced in long-term users of aspirin at doses of 300 mg daily (relative risk = 0.6; 95% confidence interval = 0.4-0.9). Daily doses of 75 and 150 mg aspirin were not associated with a reduced risk of colorectal cancer. Our data support the existence of an important protective effect of nonaspirin NSAID continuous intake against colorectal cancer and point to a similar reduction in risk for aspirin at doses of at least 300 mg daily. One-year treatment with NSAIDs would prevent one case of colorectal cancer in a population of 1,000 persons 70-79 years of age.

Integrity signals

Registry

Crossref · 10.1097/00001648-200101000-00015

Cites

29 of 29 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas
Eberhart, C. E., Coffey, R. J., Aramandla, R., Giardiello, F. M., Ferrenbach, S., & DuBois, R. N. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90246-1 · Cited by 2,512
Aspirin and the Risk of Colorectal Cancer in Women
Giovannucci, E. L., Egan, K. M., Hunter, D. J., Stampfer, M. J., Colditz, G. A., Willett, W. C., & Speizer, F. E. (1995) · New England Journal of Medicine · doi:10.1056/nejm199509073331001 · Cited by 1,095
Aspirin use and risk of fatal cancer.
Thun, M. J., Namboodiri, M. M., Calle, E. E., Flanders, W. D., & Heath, C. W. (1993) · PubMed · Cited by 870
Validation of information recorded on general practitioner based computerised data resource in the United Kingdom.
Jick, H., Jick, S. S., & Derby, L. E. (1991) · BMJ · doi:10.1136/bmj.302.6779.766 · Cited by 839
Aspirin Use and the Risk for Colorectal Cancer and Adenoma in Male Health Professionals
Giovannucci, E. L., Rimm, E. B., Stampfer, M. J., Colditz, G. A., Ascherio, A., & Willett, W. C. (1994) · Annals of Internal Medicine · doi:10.7326/0003-4819-121-4-199408150-00001 · Cited by 784
Aspirin Use and Lung, Colon, and Breast Cancer Incidence in a Prospective Study
Schreinemachers, D. M., & Everson, R. B. (1994) · Epidemiology · doi:10.1097/00001648-199403000-00003 · Cited by 738
Colorectal cancer risk, chronic illnesses, operations and medications: case control results from the Melbourne Colorectal Cancer Study
Kune, G. A., Kune, S., & Watson, L. F. (2007) · International Journal of Epidemiology · doi:10.1093/ije/dym193 · Cited by 654
Incidence of Cancer Among Patients With Rheumatoid Arthritis
Gridley, G., McLaughlin, J. K., Ekbom, A., Klareskog, L., Adami, H., Hacker, D. G., Hoover, R. N., & Fraumeni, J. F. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.4.307 · Cited by 580
Prophylactic aspirin and risk of peptic ulcer bleeding
Weil, J., Colin-Jones, D. G., Langman, M. J. S., Lawson, D. H., Logan, R., Murphy, M. S., Rawlins, M. D., Vessey, M. P., & Wainwright, P. (1995) · BMJ · doi:10.1136/bmj.310.6983.827 · Cited by 563

Show all 29 references

Research works printed but not linked: 4

Vainio, 1997, Cancer Epidemiol Biomarkers Prev, 6, 749
Kune, 1988, Cancer Res, 48, 4399
Reeves, 1996, Cancer Epidemiol Biomarkers Prev, 5, 955
Thun, 1993, Cancer Res, 53, 1322

Sorted by citations

Items 101–200 of 358

Involvement of store-operated calcium signaling in EGF-mediated COX-2 gene activation in cancer cells
Wang, J., Chen, B., Wang, Y., Tsai, Y.-T., Chen, W.-C., Chang, W., Hou, M., Wu, Y., & Chang, W.-C. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.08.017 · Cited by 73
Long-Term Use of Angiotensin Receptor Blockers and the Risk of Cancer
Azoulay, L., Assimes, T. L., Yin, H., Bartels, D. B., Schiffrin, E. L., & Suissa, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050893 · Cited by 74
Biophysical study of the non-steroidal anti-inflammatory drugs (NSAID) ibuprofen, naproxen and diclofenac with phosphatidylserine bilayer membranes
Manrique-Moreno, M., Heinbockel, L., Suwalsky, M., Garidel, P., & Brandenburg, K. (2016) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2016.06.009 · Cited by 72
Diabetes conveys a higher risk of gastric cancer mortality despite an age-standardised decreasing trend in the general population in Taiwan
Tseng, C. (2010) · Gut · doi:10.1136/gut.2010.226522 · Cited by 71
Robust Machine Learning for Colorectal Cancer Risk Prediction and Stratification
Nartowt, B. J., Hart, G. R., Muhammad, W., Liang, Y., Stark, G. F., & Deng, J. (2020) · Frontiers in Big Data · doi:10.3389/fdata.2020.00006 · Cited by 77
Indomethacin Inhibits Cancer Cell Migration via Attenuation of Cellular Calcium Mobilization
Guo, Y.-C., Chang, C., Hsu, W., Chiu, S.-J., Tsai, Y.-T., Chou, Y., Hou, M., Wang, J., Lee, M.-H., Tsai, K.-L., et al. (2013) · Molecules · doi:10.3390/molecules18066584 · Cited by 70
Leflunomide: A promising drug with good antitumor potential
Zhang, C., & Chu, M. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.01.107 · Cited by 69
Non-steroidal anti-inflammatory drug use is associated with reduction in recurrence of advanced and non-advanced colorectal adenomas (United States)
Tangrea, J. A., Albert, P. S., Lanza, E., Woodson, K. G., Corle, D. K., Hasson, M. A., Burt, R., Caan, B. J., Paskett, E. D., Iber, F. L., et al. (2003) · Cancer Causes & Control · doi:10.1023/a:1024990617158 · Cited by 69
Colorectal Adenomas
Kelloff, G. J., Schilsky, R. L., Alberts, D. S., Day, R. W., Guyton, K. Z., Pearce, H. L., Peck, J. C., Phillips, R., & Sigman, C. C. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-03-0789 · Cited by 68
Aspirin, NSAID, and Acetaminophen Use and the Risk of Endometrial Cancer
Viswanathan, A. N., Feskanich, D., Schernhammer, E. S., & Hankinson, S. E. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6257 · Cited by 67
Intake of trans fat and all-cause mortality in the Reasons for Geographical and Racial Differences in Stroke (REGARDS) cohort
Kiage, J. N., Merrill, P. D., Robinson, C., Cao, Y., Malik, T. A., Hundley, B. C., Lao, P., Judd, S. E., Cushman, M., Howard, V. J., et al. (2013) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.049064 · Cited by 67
COX and cancer
Mazhar, D., Gillmore, R., & Waxman, J. (2005) · QJM · doi:10.1093/qjmed/hci119 · Cited by 65
Extra-Virgin Olive Oil from Apulian Cultivars and Intestinal Inflammation
Cariello, M., Contursi, A., Gadaleta, R. M., Piccinin, E., Santis, S. D., Piglionica, M., Spaziante, A. F., Sabbà, C., Villani, G., & Moschetta, A. (2020) · Nutrients · doi:10.3390/nu12041084 · Cited by 65
Thyroid Dysfunction, Thyroid Hormone Replacement and Colorectal Cancer Risk
Boursi, B., Haynes, K., Mamtani, R., & Yang, Y. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv084 · Cited by 64
Use of NSAIDs for the Chemoprevention of Colorectal Cancer
Herendeen, J. M., & Lindley, C. M. (2003) · Annals of Pharmacotherapy · doi:10.1345/aph.1c489 · Cited by 64
Nonsteroidal Anti-inflammatory Drugs and Subsite-Specific Colorectal Cancer Incidence in the Iowa Women's Health Study
Mahipal, A., Anderson, K. E., Limburg, P. J., & Folsom, A. R. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-05-0674 · Cited by 63
Nonsteroidal Anti-inflammatory Drugs and Risk of Esophageal and Gastric Cancer
Lindblad, M., Lagergren, J., & Rodríguez, L. A. G. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-04-0467 · Cited by 63
Chemoprevention of gastrointestinal malignancies with nonsteroidal antiinflammatory drugs
Shaheen, N. J., Straus, W. L., & Sandler, R. S. (2002) · Cancer · doi:10.1002/cncr.10333 · Cited by 63
Infiltrating macrophage count: A significant predictor for the progression and prognosis of oral squamous cell carcinomas in Taiwan
Lu, C., Huang, C., Tjiu, J., & Chiang, C. (2009) · Head & Neck · doi:10.1002/hed.21138 · Cited by 63
Dose–Risk and Duration–Risk Relationships between Aspirin and Colorectal Cancer: A Meta-Analysis of Published Cohort Studies
Ye, X., Fu, J., Yang, Y., & Chen, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057578 · Cited by 63
Unusual anti-leukemia activity of nanoformulated naproxen and other non-steroidal anti-inflammatory drugs
Kumar, R., Siril, P. F., & Javid, F. A. (2016) · Materials Science and Engineering C · doi:10.1016/j.msec.2016.08.024 · Cited by 61
Risk of colorectal cancer in self‐reported inflammatory bowel disease and modification of risk by statin and NSAID use
Samadder, N. J., Mukherjee, B., Huang, S., Ahn, J., Rennert, H. S., Greenson, J. K., Rennert, G., & Gruber, S. B. (2010) · Cancer · doi:10.1002/cncr.25731 · Cited by 60
Hereditary Cancer Syndromes—A Primer on Diagnosis and Management
Samadder, N. J., Giridhar, K. V., Baffy, N. J., Riegert‐Johnson, D. L., & Couch, F. J. (2019) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2019.02.017 · Cited by 64
Aspirin and Cancer Risk: A Summary Review to 2007
Bosetti, C., Gallus, S., & Vecchia, C. L. (2008) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-540-69297-3_22 · Cited by 59
Projecting the number of patients with colorectal carcinoma by phases of care in the US: 2000–2020
Mariotto, A. B., Yabroff, K. R., Feuer, E. J., Angelis, R. D., & Brown, M. L. (2006) · Cancer Causes & Control · doi:10.1007/s10552-006-0072-0 · Cited by 59
Non-aspirin non-steroidal anti-inflammatory drugs in prevention of colorectal cancer in people aged 40 or older: A systematic review and meta-analysis
Tomić, T., Domínguez-López, S., & Barrios‐Rodríguez, R. (2018) · Cancer Epidemiology · doi:10.1016/j.canep.2018.11.002 · Cited by 59
COVID‐19: A Case for Inhibiting NLRP3 Inflammasome, Suppression of Inflammation with Curcumin?
Saeedi‐Boroujeni, A., Mahmoudian‐Sani, M., Bahadoram, M., & Alghasi, A. (2020) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13503 · Cited by 57
Fifty years with aspirin and platelets
Patrono, C. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15966 · Cited by 58
Nonsteroidal anti‐inflammatory drugs and risk of lung cancer
Hernández–Dı́az, S., & Rodríguez, L. A. G. (2007) · International Journal of Cancer · doi:10.1002/ijc.22514 · Cited by 56
Proton pump inhibitors on pancreatic cancer risk and survival
Kearns, M. D., Boursi, B., & Yang, Y. (2017) · Cancer Epidemiology · doi:10.1016/j.canep.2016.12.006 · Cited by 56
An Industrial and Sustainable Platform for the Production of Bioactive Micronized Powders and Extracts Enriched in Polyphenols From Olea europaea L. and Vitis vinifera L. Wastes
Romani, A., Campo, M., Urciuoli, S., Marrone, G., Noce, A., & Bernini, R. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.00120 · Cited by 55
Inhibition of tumor angiogenesis by non-steroidal anti-inflammatory drugs: emerging mechanisms and therapeutic perspectives
Dermond, O., & Rüegg, C. (2001) · Drug Resistance Updates · doi:10.1054/drup.2001.0219 · Cited by 56
Chronic statin therapy and the risk of colorectal cancer
Yang, Y., Hennessy, S., PROPERT, K. J., Hwang, W., Sarkar, M., & Lewis, J. D. (2008) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1599 · Cited by 54
El Proyecto BIFAP: Base de datos para la Investigación Farmacoepidemiológica en Atención Primaria
Rosa, A. S., Pérez, J. C. M., Sonego, D., Rodriguez, L. A. G., & de Abajo, F. J. (2002) · Atención Primaria · doi:10.1016/s0212-6567(02)79129-4 · Cited by 54
The association between genetically elevated polyunsaturated fatty acids and risk of cancer
Haycock, P., Borges, M. C., Burrows, K., Lemaître, R. N., Burgess, S., Khankari, N. K., Tsilidis, K. K., Gaunt, T. R., Hemani, G., Zheng, J., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104510 · Cited by 49
Non-steroidal anti-inflammatory drugs and pancreatic cancer risk: a nested case–control study
Bradley, M. C., Hughes, C. M., Cantwell, M. M., Napolitano, G., & Murray, L. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605636 · Cited by 53
Guía de práctica clínica sobre la prevención del cáncer colorrectal
Castells, A., Marzo, M., Bellas, B., Amador, F. J., Lanas, Á., Mascort, J. J., Ferrándiz, J., Alonso‐Coello, P., Piñol, V., Fernández, M., et al. (2004) · Gastroenterología y Hepatología · doi:10.1016/s0210-5705(03)70535-4 · Cited by 52
Age-related risk of mortality from bladder cancer in diabetic patients: A 12-year follow-up of a national cohort in Taiwan
Tseng, C., Chong, C., Tseng, C., & Chan, T.-T. (2009) · Annals of Medicine · doi:10.1080/07853890902729778 · Cited by 51
Aspirin and cancer risk: an update to 2001
Bosetti, C., Gallus, S., & Vecchia, C. L. (2002) · European Journal of Cancer Prevention · doi:10.1097/00008469-200212000-00005 · Cited by 50
Initial metformin or sulphonylurea exposure and cancer occurrence among patients with type 2 diabetes mellitus
Qiu, H., Rhoads, G. G., Berlin, J. A., Marcella, S. W., & Demissie, K. (2012) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12036 · Cited by 49
Aspirin and other non-steroidal anti-inflammatory drugs and risk of colorectal cancer: A Danish cohort study
Friis, S., Poulsen, A. H., Sørensen, H. T., Tjønneland, A. M., Overvad, K., Vogel, U. B., McLaughlin, J. K., Blot, W. J., & Olsen, J. H. (2009) · Cancer Causes & Control · doi:10.1007/s10552-008-9286-7 · Cited by 48
Use of Nonsteroidal Antiinflammatory Drugs and Risk of Colon Cancer in a Population-based, Case-Control Study of African Americans and Whites
Sansbury, L. B., Millikan, R. C., Schroeder, J. C., Moorman, P. G., North, K. E., & Sandler, R. S. (2005) · American Journal of Epidemiology · doi:10.1093/aje/kwi248 · Cited by 48
Activation of cPLA 2 is required for leukotriene D 4 -induced proliferation in colon cancer cells
Parhamifar, L., Jeppsson, B. W., & Sjölander, A. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi159 · Cited by 47
Acetamides: chemotherapeutic agents for inflammation-associated cancers
Rani, P., Pal, D., Hegde, R. R., & Hashim, S. R. (2015) · Journal of Chemotherapy · doi:10.1179/1973947815y.0000000060 · Cited by 46
NSAIDS and gastrointestinal cancer
Piazuelo, E., & Lanas, Á. (2015) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2015.06.001 · Cited by 48
Low-Dose Aspirin in the Primary Prevention of Cancer. The Women’s Health Study: A Randomized Controlled Trial
Cook, N. R., Lee, I.-M. M., & Gaziano, J. M. (2005) · ACC Current Journal Review · doi:10.1016/j.accreview.2005.09.031 · Cited by 46
Early Neoplastic Progression Is Complement Independent
de Visser, K. E., Korets, L. V., & Coussens, L. M. (2004) · Neoplasia · doi:10.1593/neo.04250 · Cited by 46
Nimesulide — Actions and Uses
Rainsford, K. D. (2005) · Birkhäuser Basel eBooks · doi:10.1007/3-7643-7410-1 · Cited by 46
Exposure to cyclooxygenase-2 inhibitors and risk of cancer: nested case–control studies
Vinogradova, Y., Coupland, C. A. C., & Hippisley‐Cox, J. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.252 · Cited by 48
Prostaglandin-endoperoxide synthase 2 (cyclooxygenase-2), a complex target for colorectal cancer prevention and therapy
Benelli, R., Venè, R., & Ferrari, N. (2018) · Translational research · doi:10.1016/j.trsl.2018.01.003 · Cited by 45
NSAIDs and Gastrointestinal Cancer Prevention
Jolly, K. B., Cheng, K. K., & Langman, M. J. S. (2002) · Drugs · doi:10.2165/00003495-200262060-00006 · Cited by 45
Cyclooxygenase polymorphisms in gastric and colorectal carcinogenesis: are conclusive results available?
Pereira, C., Medeiros, R., & Dinis-Ribeiro, M. J. (2008) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e32830ce7ba · Cited by 43
Correlation between expression of cyclooxygenase-2 and angiogenesis in human gastric adenocarcinoma
Li, H. (2003) · World Journal of Gastroenterology · doi:10.3748/wjg.v9.i4.674 · Cited by 43
Aspirin, non-steroidal anti-inflammatory drugs and colorectal neoplasia: future challenges in chemoprevention
Chan, A. T. (2003) · Cancer Causes & Control · doi:10.1023/a:1024986220526 · Cited by 42
Toll-like receptor signalling and their therapeutic targeting in colorectal cancer
Moossavi, S., & Rezaei, N. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.03.017 · Cited by 40
The Future of Colon Cancer Prevention
Umar, A., Viner, J. L., & Hawk, E. T. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb02730.x · Cited by 41
Prostate cancer mortality in Taiwanese men: Increasing age-standardized trend in general population and increased risk in diabetic men
Tseng, C. (2011) · Annals of Medicine · doi:10.3109/07853890.2010.530683 · Cited by 39
The Role of Cyclooxygenase-2 Inhibition for the Prevention and Treatment of Prostate Carcinoma
Lin, D. W., & Nelson, P. S. (2003) · Clinical Prostate Cancer · doi:10.3816/cgc.2003.n.020 · Cited by 39
Cyclooxygenase 2 Expression in Colorectal Cancer with DNA Mismatch Repair Deficiency
Castells, A., Payá, A., Alenda, C., Rodríguez‐Moranta, F., Agrelo, R., Andreu, M. G., Piñol, V., Castellvı́-Bel, S., Jover, R., Llor, X., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1581 · Cited by 38
COX-2 Polymorphism, Use of Nonsteroidal Anti-Inflammatory Drugs, and Risk of Colon Cancer in African Americans (United States)
Sansbury, L. B., Millikan, R. C., Schroeder, J. C., North, K. E., Moorman, P. G., Keku, T. O., de Cotret, A. R., Player, J., & Sandler, R. S. (2006) · Cancer Causes & Control · doi:10.1007/s10552-005-0417-0 · Cited by 38
Significance of the preoperative neutrophil-to-lymphocyte ratio in the prognosis of patients with gastric cancer
Yu, L. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i20.6280 · Cited by 38
Prevention of colorectal cancer and dietary management.
Hou, N., Huo, D., & Dignam, J. J. (2013) · PubMed · doi:10.3978/j.issn.2304-3865.2013.04.03 · Cited by 37
Aspirin use and risk for lung cancer: a meta-analysis
Oh, S., Myung, S., Park, J. Y., Lee, C. M., & Kwon, H. T. (2011) · Annals of Oncology · doi:10.1093/annonc/mdq779 · Cited by 36
COX-2 overexpression in canine tumors: potential therapeutic targets in oncology.
Spugnini, E. P., Porrello, A., Citro, G., & Baldi, A. (2005) · PubMed · doi:10.14670/hh-20.1309 · Cited by 36
A clinical perspective on the role of chronic inflammation in gastrointestinal cancer
Alguel, H., & Rasch, S. (2014) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s43457 · Cited by 37
Luminescent fac -[Re(CO) 3 (phen)] carboxylato complexes with non-steroidal anti-inflammatory drugs: synthesis and mechanistic insights into the in vitro anticancer activity of fac -[Re(CO) 3 (phen)(aspirin)]
Skiba, J., Kowalczyk, A., Stączek, P., Bernaś, T., Trzybiński, D., Woźniak, K., Schatzschneider, U., Czerwieniec, R., & Kowalski, K. (2018) · New Journal of Chemistry · doi:10.1039/c8nj05494k · Cited by 38
Physical exercise, use of Plantago ovata and aspirin, and reduced risk of colon cancer
Juarranz, M., Calle-Purón, M.-E., González-Navarro, A., Regidor, E., Soriano, T., Hernández, D. M., Rojas, V.-D., & Guinee, V. F. (2002) · European Journal of Cancer Prevention · doi:10.1097/00008469-200210000-00009 · Cited by 35
Targeting Inflammation to Improve Tumor Drug Delivery
Gkretsi, V., Zacharia, L. C., & Stylianopoulos, T. (2017) · Trends in cancer · doi:10.1016/j.trecan.2017.07.006 · Cited by 34
The role of aspirin in colorectal cancer chemoprevention
Ranger, G. S. (2016) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2016.05.011 · Cited by 33
Mechanisms underlying aspirin-mediated growth inhibition and apoptosis induction of cyclooxygenase-2 negative colon cancer cell line SW480
Lai, M., Huang, J.-A., Liang, Z., Jiang, H., & Tang, G. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.4227 · Cited by 33
A Population-Based Cohort Study of Mortality Among Users of Ibuprofen in Denmark
Lipworth, L., Friis, S., Blot, W. J., McLaughlin, J. K., Mellemkjær, L., Johnsen, S. P., Nørgaard, B., & Olsen, J. H. (2004) · American Journal of Therapeutics · doi:10.1097/00045391-200405000-00002 · Cited by 33
The Role of NSAIDs in the Prevention of Colon Cancer
Rayyan, Y. M., Williams, J. L., & Rigas, B. (2002) · Cancer Investigation · doi:10.1081/cnv-120005917 · Cited by 33
Aspirin, ibuprofen, and reduced risk of advanced colorectal adenoma incidence and recurrence and colorectal cancer in the PLCO Cancer Screening Trial
Chudy‐Onwugaje, K., Huang, W., Su, L. J., Purdue, M. P., Johnson, C. C., Wang, L., Katki, H. A., Barry, K. H., & Berndt, S. I. (2021) · Cancer · doi:10.1002/cncr.33623 · Cited by 31
Anti‐tumor platinum (IV) complexes bearing the anti‐inflammatory drug naproxen in the axial position
Tolan, D. A., Abdel-Monem, Y. K., & El‐Nagar, M. A. (2019) · Applied Organometallic Chemistry · doi:10.1002/aoc.4763 · Cited by 32
Exploring the Links Between Systemic Lupus Erythematosus and Cancer
Bernatsky, S., Ramsey‐Goldman, R., & Clarke, A. E. (2005) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2005.01.002 · Cited by 31
The Association between Aspirin Use and the Incidence of Colorectal Cancer in Women
Allison, M., Garland, C., Chlebowski, R. T., Criqui, M. H., Langer, R., Wu, L., Roy, H. K., McTiernan, A., & Kuller, L. H. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj250 · Cited by 31
Apoptosis Induced by Aspirin and 5-Fluorouracil in Human Colonic Adenocarcinoma Cells
Ashktorab, H., Dawkins, F. W., Mohamed, R., Larbi, D. A., & Smoot, D. T. (2005) · Digestive Diseases and Sciences · doi:10.1007/s10620-005-2698-2 · Cited by 30
Introduction to colorectal cancer
Shelton, B. K. (2002) · Seminars in Oncology Nursing · doi:10.1053/sonu.2002.33074 · Cited by 30
Cyclooxygenase-2 is over-expressed in Chinese esophageal squamous cell carcinoma, and correlated with NF-κB: An immunohistochemical study
Yang, G.-Z., Li, L., Ding, H.-Y., & Zhou, J. (2005) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2005.09.002 · Cited by 30
Potential effect of cyclooxygenase-2–specific inhibitors on the prevention of colorectal cancer: a cost-effectiveness analysis
Ladabaum, U., Scheiman, J. M., & Fendrick, A. M. (2003) · The American Journal of Medicine · doi:10.1016/s0002-9343(03)00095-0 · Cited by 30
Activation of Peroxisome Proliferator-Activated Receptor γ Does Not Explain the Antiproliferative Activity of the Nonsteroidal Anti-Inflammatory Drug Indomethacin on Human Colorectal Cancer Cells
Hawcroft, G., Gardner, S. H., & Hull, M. A. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.048769 · Cited by 29
The Importance of Human Data in the Establishment of Occupational Exposure Limits
Sargent, E. V., Naumann, B. D., Dolan, D. G., Faria, E. C., & Schulman, L. (2002) · Human and Ecological Risk Assessment An International Journal · doi:10.1080/10807030290879961 · Cited by 28
Infection and Inflammation: Impacts on Oncogenesis
Dittmar, T., Zaenker, K. S., & Schmidt, A. (2006) · Contributions to microbiology · doi:10.1159/isbn.978-3-318-01310-8 · Cited by 28
Higher risk of mortality from lung cancer in Taiwanese people with diabetes
Tseng, C. (2013) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2013.10.019 · Cited by 27
Analgesic medication use and risk of epithelial ovarian cancer in African American women
Peres, L. C., CAMACHO, F. T., Abbott, S. E., Alberg, A. J., Bandera, E. V., Barnholtz‐Sloan, J. S., Bondy, M. L., Coté, M. L., Crankshaw, S., Funkhouser, E. M., et al. (2016) · British Journal of Cancer · doi:10.1038/bjc.2016.39 · Cited by 26
Prevención del cáncer colorrectal
Andreu, M. G., Marzo‐Castillejo, M., Mascort, J., Quintero, E., Alfonso, P. G., López-Ibor, C., Castells, A., & Segura, P. P. (2009) · Gastroenterología y Hepatología · doi:10.1016/j.gastrohep.2008.12.001 · Cited by 26
Thiazolidinedione Therapy Is Not Associated With Increased Colonic Neoplasia Risk in Patients With Diabetes Mellitus
Lewis, J. D., Capra, A. M., Achacoso, N. S., Ferrara, A. M., Levin, T. R., Quesenberry, C. P., & Habel, L. A. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.09.004 · Cited by 24
Phytochemical studies, antiangiogenic, anti-inflammatory and antioxidant activities of Scyphocephalium ochocoa Warb. (Myristicaceae), medicinal plant from Gabon
Misso, R.-L. N. M., Ndong, J. D. L. C., Obiang, C. S., Ondo, J. P., Ndong-Atome, G.-R., Abessolo, F. O., & Obame-Engonga, L.-C. (2018) · Clinical Phytoscience · doi:10.1186/s40816-018-0075-x · Cited by 24
Anticancer molecular mechanisms of oleocanthal
Haouari, M. E., Quintero, J. E., & Rosado, J. A. (2020) · Phytotherapy Research · doi:10.1002/ptr.6722 · Cited by 23
Genomic instability in chronic obstructive pulmonary disease and lung cancer: A systematic review and meta-analysis of studies using the micronucleus assay
Асанов, М. А., Bonassi, S., Proietti, S., Minina, V. I., Tomino, C., & El‐Zein, R. A. (2020) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2020.108344 · Cited by 21
Colorectal Cancer: What Should Patients and Families Be Told to Lower the Risk of Colorectal Cancer?
Moore, H. G. (2010) · Surgical Oncology Clinics of North America · doi:10.1016/j.soc.2010.06.002 · Cited by 22
Epidemiology and molecular pathology at crossroads to establish causation: molecular mechanisms of malignant transformation
Bocchetta, M., & Carbone, M. (2004) · Oncogene · doi:10.1038/sj.onc.1207855 · Cited by 23
Molecular mechanisms involved in the antiproliferative effect of two COX-2 inhibitors, nimesulide and NS-398, on colorectal cancer cell lines
Buecher, B., Broquet, A. H., Bouancheau, D., Heymann, M., Jarry, A., Denis, M. G., Bonnet, C., Galmiche, J., & Blottière, H. M. (2003) · Digestive and Liver Disease · doi:10.1016/s1590-8658(03)00272-x · Cited by 22
The Bitter Barricading of Prostaglandin Biosynthesis Pathway: Understanding the Molecular Mechanism of Selective Cyclooxygenase-2 Inhibition by Amarogentin, a Secoiridoid Glycoside from Swertia chirayita
Shukla, S. P., Bafna, K., Sundar, D., & Thorat, S. S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090637 · Cited by 21
The association between low-dose aspirin use and the incidence of colorectal cancer: a nationwide cohort study
Huang, W., Chiou, M.-J., Yu, K., Lin, Y., Yang, T., Chen, J.-S., Kuo, C. ‐., & See, L. (2013) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12388 · Cited by 21
Cyclooxygenase-2 inhibition in colorectal cancer: Boom or bust?
Sanborn, R. E., & Blanke, C. D. (2005) · Seminars in Oncology · doi:10.1053/j.seminoncol.2004.09.035 · Cited by 21
Cyclooxygenase inhibition in cancer prevention and treatment
Anderson, W. F., Umar, A., & Hawk, E. T. (2003) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.4.12.2193 · Cited by 21
Low-Dose Aspirin and Prevention of Colorectal Cancer: Evidence From a Nationwide Registry-Based Cohort in Norway
Nafisi, S., Støer, N. C., Veierød, M. B., Randel, K. R., Hoff, G. S., Löfling, L., Bosetti, C., & Botteri, E. (2024) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000002695 · Cited by 20
Oleocanthal: A Naturally Occurring Anti-Inflammatory Agent in Virgin Olive Oil
Cicerale, S., J., L., & Keast, R. (2012) · InTech eBooks · doi:10.5772/28723 · Cited by 20
SOX7 is involved in aspirin-mediated growth inhibition of human colorectal cancer cells
Zhou, X. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i44.4922 · Cited by 20

Authors: García Rodríguez, L. A., & Huerta-Alvarez, C.
Venue: Epidemiology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2001-01
Volume: 12
Issue: 1
Pages: 88-93
ISSN: 1044-3983 (ISSN-L)
DOI: 10.1097/00001648-200101000-00015
OpenAlex: W1971370481
Cited by: 359
References: 29
Citations by year: 2026: 1 · 2025: 2 · 2024: 5 · 2023: 8 · 2022: 4 · 2021: 5 · 2020: 11 · 2019: 6 · 2018: 11 · 2017: 10 · 2016: 16 · 2015: 15 · 2014: 11 · 2013: 14 · 2012: 19
FWCI: 16.04
Type: journal article
Language: en
Open access: closed
Locations: Epidemiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
Keywords: colorectal cancer, aspirin, nonsteroidal anti-inflammatory drugs, chemoprevention, dose-response relationship, long-term drug use, cancer incidence, colorectal adenoma
MeSH terms: Adenoma, Adult, Aged, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Female, United Kingdom, Humans, Male, Middle Aged, Risk Factors, Colorectal Neoplasms, Cohort Studies, Incidence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Reduced Risk of Colorectal Cancer among Long-Term Users of Aspirin and Nonaspirin Nonsteroidal Antiinflammatory Drugs

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks