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Concomitant induction of apoptosis and necrosis in cerebellar granule cells following serum and potassium withdrawal
Abstract
Serum and potassium withdrawal-induced cell death of cerebellar granule cells is one of the most popular models used for studying neuronal apoptosis in vitro, and it is generally assumed that compounds preventing cell death in this model prevent apoptosis. In the present study we demonstrate that serum and potassium withdrawal induces a mixture of apoptosis and necrosis rather than apoptosis only. Each of these death mechanisms could be blocked by activation of different pathways, such as raising cAMP production or stimulation of the IGF-1 receptor. Studies on serum and potassium withdrawal-induced cell death of cerebellar granule cells should therefore carefully assess whether a given compound is preventing apoptosis or necrosis using appropriate techniques.
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PCSK9 RNAi CGN survival was reduced by 24 h.
“However, even in the PCSK9 RNAi, CGN survival was reduced by 24 h, possibly due to activation of other, nonapoptotic cell death pathways [28].”
From PCSK9 regulates neuronal apoptosis by adjusting ApoER2 levels and signaling (2012) · cites this paper as [28]
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Research works printed but not linked: 6
- 1987, EMBO J, 6, 1145, 10.1002/j.1460-2075.1987.tb02347.x · DOI
- 1989, Neuron, 2, 1525, 10.1016/0896-6273(89)90040-8 · DOI · Paper page
- 1996, J Neurosci, 16, 1150, 10.1523/JNEUROSCI.16-03-01150.1996 · DOI
- 1996, Neurosci Lett, 206, 181, 10.1016/S0304-3940(96)12468-X · DOI
- 1995, NeuroReport, 7, 61, 10.1097/00001756-199512000-00014 · DOI
- 1995, Science, 267, 2003, 10.1126/science.7701324 · DOI
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PCSK9 regulates neuronal apoptosis by adjusting ApoER2 levels and signaling
Kysenius, K., Muggalla, P., Mätlik, K., Arumäe, U., & Huttunen, H. J. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0977-6 · Cited by 137
Metadata
- Authors
- Villalba, M., Bockaert, J., & Journot, L.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- NeuroReport
- Published
- 1997-03
- Volume
- 8
- Issue
- 4
- Pages
- 981-985
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2016111983
- Cited by
- 55
- References
- 0
- Citations by year
- 2024: 1 · 2021: 1 · 2020: 2 · 2015: 2 · 2014: 1 · 2012: 3
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- apoptosis, necrosis, cerebellar granule cells, serum deprivation, neuronal cell death, cyclic AMP, IGF-1 receptor
- MeSH terms
- Wortmannin, Androstadienes, Animals, Cell Survival, Cells, Cultured, Cerebellum, Chromones, Culture Media, DNA, Enzyme Inhibitors, Colforsin, Insulin-Like Growth Factor I, Morpholines, Necrosis, Neurons, Neuropeptides, Potassium, Culture Media, Serum-Free, Cell Death, Rats, Wistar, Apoptosis, Phosphotransferases (Alcohol Group Acceptor), Neuroprotective Agents, Phosphatidylinositol 3-Kinases, Pituitary Adenylate Cyclase-Activating Polypeptide, Rats, DNA Fragmentation
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