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Regional calpain and caspase-3 proteolysis of α-spectrin after traumatic brain injury
Abstract
Activity of calpains and caspase-3 inferred from proteolysis of the cytoskeletal protein alpha-spectrin into signature spectrin breakdown products (SBDPs) was used to provide the first systematic and simultaneous comparison of changes in activity of these two families of cysteine proteases after traumatic brain injury (TBI) in rats. Distinct regional and temporal patterns of calpain/caspase-3 processing of alpha-spectrin were observed in brain regions ipsilateral to the site of injury after TBI, including large increases of 145 kDa calpain-mediated SBDP in cortex (up to 30-fold), and enduring increases (up to 2 weeks) of 145 kDa SBDP in hippocampus and thalamus. By contrast, 120 kDa caspase-3-mediated SBDP was absent in cortex and showed up to a 2-fold increase in hippocampus and striatum at early (hours) after TBI. Future studies will clarify the pathological significance of large regional differences in activation of calpain and caspase-3 proteases after TBI.
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Cited by
Calpain and caspase: can you tell the difference?
Wang, K. K. W. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01479-4 · Cited by 912
Self-citationKim, Y. J., Yi, Y., Sapp, E., Wang, Y., Cuiffo, B., Kegel, K. B., Qin, Z.-H., Aronin, N., & DiFiglia, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221451398 · Cited by 398
Activation of the caspase-3 apoptotic cascade in traumatic spinal cord injury
Springer, J. E., Azbill, R. D., & Knapp, P. E. (1999) · Nature Medicine · doi:10.1038/11387 · Cited by 371
Andriessen, T. M. J. C., Jacobs, B., & Vos, P. E. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01164.x · Cited by 369
Calpain Activation in Huntington's Disease
Gafni, J., & Ellerby, L. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-12-04842.2002 · Cited by 331
Metadata
- Authors
- Pike, B. R., Zhao, X., Newcomb, J. K., Posmantur, R. M., Wang, K. K., & Hayes, R. L.
- Venue
- NeuroReport
- Published
- 1998-08
- Volume
- 9
- Issue
- 11
- Pages
- 2437-2442
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2171390337
- Cited by
- 204
- References
- 0
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pike, B. R., Zhao, X., Newcomb, J. K., Posmantur, R. M., Wang, K. K., & Hayes, R. L. (1998). Regional calpain and caspase-3 proteolysis of α-spectrin after traumatic brain injury. NeuroReport. https://doi.org/10.1097/00001756-199808030-00002
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