Opioid-induced hyperalgesia: abnormal or normal pain?

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Enduring changes in brain and behavior produced by chronic amphetamine administration: A review and evaluation of animal models of amphetamine psychosis

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Has Central Sensitization Become Independent of Nociceptive Input in Chronic Pancreatitis Patients Who Fail Thoracoscopic Splanchnicectomy?

Bouwense, S. A. W., Buscher, H. C. J. L., van Goor, H., & Wilder‐Smith, O. H. G. (2011) · Regional Anesthesia & Pain Medicine · doi:10.1097/aap.0b013e31822e0d4a · Cited by 38

Prevention of fentanyl-induced delayed pronociceptive effects in mice lacking the protein kinase Cγ gene

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Morphine-6β-glucuronide Rapidly Increases Pain Sensitivity Independently of Opioid Receptor Activity in Mice and Humans

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Tachykinin NK1 receptor antagonist co-administration attenuates opioid withdrawal-mediated spinal microglia and astrocyte activation

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Experience of handicap and anxiety in phobic postural vertigo

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Postoperative hyperalgesia—A clinically applicable narrative review

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Dual enkephalinase inhibitor PL265: a novel topical treatment to alleviate corneal pain and inflammation

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Targeting peroxynitrite driven nitroxidative stress with synzymes: A novel therapeutic approach in chronic pain management

Salvemini, D., & Neumann, W. L. (2009) · Life Sciences · doi:10.1016/j.lfs.2009.06.011 · Cited by 36

Effects of a loading dose of morphine before i.v. morphine titration for postoperative pain relief: a randomized, double-blind, placebo-control study

Aubrun, F., Amour, J., Rosenthal, D. L., Coriat, P., & Riou, B. (2006) · British Journal of Anaesthesia · doi:10.1093/bja/ael284 · Cited by 35

One or Several Types of Triptan Overuse Headaches?

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Opioid treatment and hypoalbuminemia are associated with increased hospitalisation rates in chronic pancreatitis outpatients

Olesen, S. S., Poulsen, J. L., Broberg, M., Madzak, A., & Drewes, A. M. (2016) · Pancreatology · doi:10.1016/j.pan.2016.06.004 · Cited by 35

TRV0109101, a G Protein-Biased Agonist of the µ-Opioid Receptor, Does Not Promote Opioid-Induced Mechanical Allodynia following Chronic Administration

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Development of a Peptidomimetic Antagonist of Neuropeptide FF Receptors for the Prevention of Opioid-Induced Hyperalgesia

Bihel, F. J. ‐., Humbert, J., Schneider, S., Bertin, I., Wagner, P., Schmitt, M., Laboureyras, E., Petit‐Demoulière, B., Schneider, E., Mollereau, C., et al. (2015) · ACS Chemical Neuroscience · doi:10.1021/cn500219h · Cited by 32

Poderia a atividade física induzir analgesia em pacientes com dor crônica?

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Effects of Opioid Prescription Medication Dependence and Detoxification on Pain Perceptions and Self-Reports

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Peroxynitrite and opiate antinociceptive tolerance: A painful reality

Salvemini, D. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.11.005 · Cited by 31

Reduced Cold Pain Tolerance in Chronic Pain Patients Following Opioid Detoxification

Younger, J., Barelka, P. L., Carroll, I. R., Kaplan, K., Chu, L. F., Prasad, R., Gaeta, R. R., & Mackey, S. (2008) · Pain Medicine · doi:10.1111/j.1526-4637.2008.00475.x · Cited by 29

Effects of sevoflurane on carrageenan- and fentanyl-induced pain hypersensitivity in Sprague-Dawley rats

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Early and Phasic Cortical Metabolic Changes in Vestibular Neuritis Onset

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NADPH-oxidase 2 activation promotes opioid-induced antinociceptive tolerance in mice

Doyle, T. M., Esposito, E., Bryant, L., Cuzzocrea, S., & Salvemini, D. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.02.042 · Cited by 28

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

Elhabazi, K., Ayachi, S., Ilien, B., & Simonin, F. (2014) · Journal of Visualized Experiments · doi:10.3791/51264-v · Cited by 28

GluN2B N-methyl-D-aspartate receptor and excitatory amino acid transporter 3 are upregulated in primary sensory neurons after 7 days of morphine administration in rats

Gong, K., Bhargava, A., & Jasmin, L. (2015) · Pain · doi:10.1097/j.pain.0000000000000342 · Cited by 27

Spinal ephrin B / EphB signalling contributed to remifentanil‐induced hyperalgesia via NMDA receptor

Xia, W. S., Peng, Y., Tang, L., Jiang, L., Yu, L., Zhou, X., Zhang, F. J., & Yan, M. (2014) · European Journal of Pain · doi:10.1002/j.1532-2149.2014.00478.x · Cited by 27

Effects of carrageenan and morphine on acute inflammation and pain in Lewis and Fischer rats

Fecho, K., Manning, E. L., Maixner, W. D., & Schmitt, C. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.02.003 · Cited by 27

Analgesia enhancement and prevention of tolerance to morphine: beneficial effects of combined therapy with omega-3 fatty acids

Escudero, G. E., Romañuk, C. B., Toledo, M. E., Olivera, M. E., Manzo, R. H., & Laino, C. H. (2015) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.12416 · Cited by 26

Remifentanil-induced hyperalgesia: the current state of affairs

Vitin, A. A., & Egan, T. D. (2024) · Current Opinion in Anaesthesiology · doi:10.1097/aco.0000000000001400 · Cited by 25

Preoperative opioid consumption increases morphine requirement after leg amputation

Roullet, S., Nouette‐Gaulain, K., Biais, M., Bernard, N., Bénard, A., Revel, P., Capdevila, X., & Sztark, F. (2009) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-009-9185-8 · Cited by 24

Magnesium modifies fentanyl-induced local antinociception and hyperalgesia

Mert, T., Güneş, Y., Özcengiz, D., & Günay, İ. (2009) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-009-0447-3 · Cited by 24

Opioid-Induced Hyperalgesia (OIH)

Leal, P. D. C., Clivatti, J., Garcia, J. B. S., & Sakata, R. K. (2010) · Brazilian Journal of Anesthesiology · doi:10.1016/s0034-7094(10)70080-5 · Cited by 24

Analgesic interaction between ondansetron and acetaminophen after tonsillectomy in children: The P aratron randomized, controlled trial

Ramirez, L., Cros, J., Marin, B., Boulogne, P., Bergeron, A., de Lafont, G. E., Renon-Carron, F., de Vinzelles, M.-A., Guigonis, V., Nathan, N., et al. (2014) · European Journal of Pain · doi:10.1002/ejp.587 · Cited by 23

Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude

Gerhold, K. J., Drdla-Schutting, R., Honsek, S. D., Forsthuber, L., & Sandkühler, J. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0731-14.2015 · Cited by 23

The Use of Very-Low-Dose Methadone and Haloperidol for Pain Control in the Hospital Setting: A Preliminary Report

Salpeter, S. R., Buckley, J. S., Buckley, N. S., & Bruera, E. D. (2014) · Journal of Palliative Medicine · doi:10.1089/jpm.2014.0266 · Cited by 23

Induction of c-Fos and zif268 in the nociceptive amygdala parallel abstinence hyperalgesia in rats briefly exposed to morphine

Hamlin, A. S., McNally, G. P., & Osborne, P. B. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.05.017 · Cited by 24

Behavioral characterization, potential clinical relevance and mechanisms of latent pain sensitization

Gerum, M., & Simonin, F. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108032 · Cited by 22

Neural correlates of the essence of conscious conflict: fMRI of sustaining incompatible intentions

Gray, J. R., Bargh, J. A., & Morsella, E. (2013) · Experimental Brain Research · doi:10.1007/s00221-013-3566-5 · Cited by 21

Relationships between plasma concentrations of morphine, morphine-3-glucuronide, morphine-6-glucuronide, and intravenous morphine titration outcomes in the postoperative period

Hammoud, H. A., Aymard, G., Lechat, P. P., Boccheciampe, N., Riou, B., & Aubrun, F. (2010) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2010.00867.x · Cited by 21

Analgesic properties of chimeric peptide based on morphiceptin and PFRTic-amide

Li, M., Zhou, L., Ma, G., & Dong, S. (2012) · Regulatory Peptides · doi:10.1016/j.regpep.2012.08.008 · Cited by 20

Perioperative Hyperalgesia and Associated Clinical Factors

Malik, O. S., Kaye, A. D., & Urman, R. D. (2017) · Current Pain and Headache Reports · doi:10.1007/s11916-017-0602-3 · Cited by 20

Induzieren Opioide Hyperalgesie?

Zöllner, C. (2010) · Der Anaesthesist · doi:10.1007/s00101-010-1803-x · Cited by 20

Douleur du membre fantôme : de la physiopathologie à la prévention

Roullet, S., Nouette‐Gaulain, K., Brochet, B., & Sztark, F. (2009) · Annales Françaises d Anesthésie et de Réanimation · doi:10.1016/j.annfar.2009.03.012 · Cited by 19

Tolerance and opioid-induced hyperalgesia. Is a divorce imminent?

Richebé, P., Cahana, A., & Rivat, C. (2012) · Pain · doi:10.1016/j.pain.2012.05.002 · Cited by 19

Opioidvermittelte Analgesie und Hyperalgesie

Koppert, W. (2005) · Der Schmerz · doi:10.1007/s00482-005-0424-9 · Cited by 18

Rotating Methadone to Other Opioids: A Lesson in the Mechanisms of Opioid Tolerance and Opioid-Induced Pain

Prommer, E. (2006) · Journal of Palliative Medicine · doi:10.1089/jpm.2006.9.488 · Cited by 19

Opioid Adjuvant Strategy: Improving Opioid Effectiveness

Bihel, F. J. ‐. (2016) · Future Medicinal Chemistry · doi:10.4155/fmc.15.186 · Cited by 19

Tolerance to morphine analgesia: Evidence for stimulus intensity as a key factor and complete reversal by a glycine site-specific NMDA antagonist

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N‐Methyl‐ d ‐aspartate receptor modulators block hyperalgesia induced by acute low‐dose morphine

Gupta, L., Gupta, R., & Tripathi, C. (2011) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2011.05556.x · Cited by 18

Acute pain management with intravenous 0.10mg/kg versus 0.15mg/kg morphine sulfate in limb traumatized patients: A randomized double-blinded placebo-controlled trial

Farsi, D., Movahedi, M., Hafezimoghadam, P., Abbasi, S., Shahlaee, A., & Rahimi‐Movaghar, V. (2013) · Turkish Journal of Trauma and Emergency Surgery · doi:10.5505/tjtes.2013.86383 · Cited by 17

Exogenous and Endogenous Opioid‐Induced Pain Hypersensitivity in Different Rat Strains

Laboureyras, E., Aubrun, F., Monsaingeon, M., Corcuff, J., Laulin, J., & Simonnet, G. (2014) · Pain Research and Management · doi:10.1155/2014/285308 · Cited by 18

Peripheral Sensitization

Wei, S., Tao, Z.-Y., Xue, Y., & Cao, D. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.90319 · Cited by 21

Progesterone rapidly recruits female-typical opioid-induced hyperalgesic mechanisms

Waxman, A. R., Juni, A., Kowalczyk, W. J., Arout, C. A., Sternberg, W. F., & Kest, B. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.08.018 · Cited by 18

Bolus ketamine does not decrease hyperalgesia after remifentanil infusion

Şahin, A., Canbay, Ö., Cuhadar, A., Çelebi, N., & Aypar, Ü. (2004) · The Pain Clinic · doi:10.1163/1568569042664413 · Cited by 17

Intraoperative Ketamine in Total Knee Arthroplasty Does Not Decrease Pain and Narcotic Consumption: A Prospective Randomized Controlled Trial

Tan, T. L., Longenecker, A. S., Rhee, J. H., Good, R. P., Emper, W. D., Freedman, K. B., Shaner, J. L., McComb, J. J., & Levicoff, E. (2019) · The Journal of Arthroplasty · doi:10.1016/j.arth.2019.04.017 · Cited by 18

The effect of environmental factors on morphine withdrawal in C57BL/6J mice: running wheel access and group housing

Balter, R. E., & Dykstra, L. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2826-6 · Cited by 17

Activation of spinal alpha-7 nicotinic acetylcholine receptor shortens the duration of remifentanil-induced postoperative hyperalgesia by upregulating KCC2 in the spinal dorsal horn in rats

Gu, W., Zhang, W., Lei, Y., Cui, Y., Chu, S., Gu, X., & Ma, Z. (2017) · Molecular Pain · doi:10.1177/1744806917704769 · Cited by 17

The optimal dose of dexmedetomidine added to an sufentanil-based analgesic regimen for postoperative pain control in spine surgery

Dong, C., Lu, Y., Zhang, J., Sun, P., Yu, J., Wu, C., & Lü, Q. (2016) · Medicine · doi:10.1097/md.0000000000004776 · Cited by 16

The glycine site-specific NMDA antagonist (+)-HA966 enhances the effect of morphine and reverses morphine tolerance via a spinal mechanism

Adam, F., Dufour, E., & Bars, D. L. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.11.013 · Cited by 16

Fentanyl-induced hyperalgesia and analgesic tolerance in male rats: common underlying mechanisms and prevention by a polyamine deficient diet

Laboureyras, E., Boujema, M. B., Mauborgne, A., Simmers, J., Pohl, M., & Simonnet, G. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01200-5 · Cited by 15

Thermal Pain in Complex Regional Pain Syndrome Type I

Grothusen, J. R. (2014) · Pain Physician · doi:10.36076/ppj.2014/17/71 · Cited by 15

Effect of remifentanil on postoperative pain in gynecologic surgery with sevoflurane anesthesia

Cho, A.-R., Kim, H.-K., Kim, K.-H., Jung, K. Y., Kim, W.-S., & Kwon, J. Y. (2008) · Korean Journal of Anesthesiology · doi:10.4097/kjae.2008.55.2.182 · Cited by 14

Moral Sensitivity in Young Gifted Children

Lovecky, D. V. (2009) · Springer eBooks · doi:10.1007/978-0-387-89368-6_13 · Cited by 14

Pour une psychologie de l'enfant face à la douleur

Zabalia, M. (2006) · Enfance · doi:10.3917/enf.581.0005 · Cited by 14

Kétamine en anesthésie pédiatrique : utile, futile ou … ?

Kock, M. D. (2007) · Annales Françaises d Anesthésie et de Réanimation · doi:10.1016/j.annfar.2007.04.009 · Cited by 13

A Paradigm-Shift in Pain Medicine

Wilder‐Smith, O. H. G. (2013) · doi:10.13052/rp-9788793102545 · Cited by 13

Beneficial Effects of Remifentanil Against Excitotoxic Brain Damage in Newborn Mice

Chollat, C., Lecointre, M., Leuillier, M., Rémy‐Jouet, I., do-Rego, J.-C., Abily-Donval, L., Ramdani, Y., Richard, V. J., Compagnon, P., Dureuil, B., et al. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00407 · Cited by 13

Canaux ioniques et démyélinisation : les fondements d’un traitement de l’encéphalomyélite autoimmune expérimentale (EAE) par des bloqueurs des canaux potassium

Devaux, J. J., Beeton, C., Béraud, E., & Crest, M. (2004) · Revue Neurologique · doi:10.1016/s0035-3787(04)71001-2 · Cited by 13

Modulating actions of NMDA receptors on pronociceptive effects of locally injected remifentanil in diabetic rats

Mert, T., Öksüz, H., Demir, B. T., Kılınç, M., Şenoğlu, N., & Bilgin, R. (2014) · Pharmacological Reports · doi:10.1016/j.pharep.2014.07.004 · Cited by 12

Molecular Basis and Clinical Implications of Opioid Tolerance and Opioid-Induced Hyperalgesia

Chu, L. F., Clark, J. D., & Angst, M. S. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511576706.012 · Cited by 12

Experimental behaviour testing: pain

Savage, S., & Ma, D. (2014) · British Journal of Anaesthesia · doi:10.1093/bja/aeu346 · Cited by 12

Delayed aversive effects of high-dose fentanyl

Pain, L., Oberling, P., Mainsongeon, M., Moulinoux, J.-P., & Simonnet, G. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.010 · Cited by 11

Modulation by Neuropeptide FF of the interaction of Mu-opioid (MOP) receptor with G-proteins

Kersanté, F., Moulédous, L., Zajac, J., & Mollereau, C. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2010.02.014 · Cited by 11

Opioid-induced hyperalgesia: fact or fiction?

Fallon, M., & Colvin, L. (2008) · Palliative Medicine · doi:10.1177/0269216307086857 · Cited by 11

The Dynorphin/-Opioid Receptor System at the Interface of Hyperalgesia/Hyperkatifeia and Addiction

Marchette, R. C. N., Vendruscolo, L. F., & Koob, G. F. (2025) · Current Addiction Reports · doi:10.1007/s40429-025-00618-x · Cited by 17

Rewarding effects of electrical stimulation of the insular cortex: Decayed effectiveness after repeated tests and subsequent increase in vertical behavioral activity and conditioned place aversion after naloxone administration

García, R., Zafra, M. A., & Puerto, A. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.11.008 · Cited by 10

Cerebral plasticity in acute vestibular deficit

Alessandrini, M., Napolitano, B., Bruno, E., Belcastro, L., Ottaviani, F., & Schillaci, O. (2009) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-009-0953-4 · Cited by 10

Opiate dependence induces cell type-specific plasticity of intrinsic membrane properties in the rat juxtacapsular bed nucleus of stria terminalis (jcBNST)

Francesconi, W., Szűcs, A. L., Berton, F., Koob, G. F., Vendruscolo, L. F., & Sanna, P. P. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4732-4 · Cited by 10

A high-dose of fentanyl induced delayed anxiety-like behavior in rats. Prevention by a NMDA receptor antagonist and nitrous oxide (N2O)

Bessière, B., Laboureyras, E., Boujema, M. B., Laulin, J., & Simonnet, G. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.07.002 · Cited by 10

Is Timing of Medical Therapy Related to Outcome in Painful Chronic Pancreatitis?

Olesen, S. S., Graversen, C., Bouwense, S. A. W., Wilder‐Smith, O. H. G., van Goor, H., & Drewes, A. M. (2015) · Pancreas · doi:10.1097/mpa.0000000000000475 · Cited by 10

Opiate Prescription Medication Dependence and Pain Perceptions

Miller, N. S., & Gold, M. S. (2007) · Journal of Addictive Diseases · doi:10.1300/j069v26s01_07 · Cited by 10

Towards Integrating Emotion into Intelligent Context

Moore, P. T., Evans, C., & Pham, H. V. (2013) · Lecture notes in computer science · doi:10.1007/978-3-642-38333-5_5 · Cited by 9

Complete opioid transition to sublingual Buprenorphine after abdominal surgery is associated with significant reductions in opioid requirements, but not reduction in hospital length of stay: a retrospective cohort study

Heldreich, C., Ganatra, S., Lim, Z. J., Meyer, I., Hu, R., Weinberg, L., & Tan, C. O. (2022) · BMC Anesthesiology · doi:10.1186/s12871-021-01531-2 · Cited by 9

Hiperalgesia induzida por opioides (HIO)

Leal, P. D. C., Clivatti, J., Garcia, J. B. S., & Sakata, R. K. (2010) · Brazilian Journal of Anesthesiology · doi:10.1590/s0034-70942010000600011 · Cited by 9

Morphine consumption is not modified in patients with severe pain and classified by the DN4 score as neuropathic

Lvovschi, V.-E., Arhan, A., Juillien, G., Montout, V., Bendahou, M., Goulet, H., Saïdi, K., & Riou, B. (2012) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2012.03.037 · Cited by 9

Tolerance to Opioid Analgesia: Why Do We Differ from Rats?

Kissin, I. (2005) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000184531.28307.dc · Cited by 9

Sensitized brain response to acute pain in patients using prescription opiates for chronic pain: a pilot study

Dowdle, L. T., Borckardt, J. J., Back, S. E., Morgan, K., Adams, D., Madan, A., Balliet, W., & Hanlon, C. A. (2019) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2019.02.024 · Cited by 8

Tolerance to repeated rewarding electrical stimulation of the insular cortex

Hurtado, M. M., García, R., & Puerto, A. (2015) · Brain Research · doi:10.1016/j.brainres.2015.11.001 · Cited by 8

A paradigm-shift in pain medicine: implementing a systematic approach to altered pain processing in everyday clinical practice based on quantitative sensory testing

Wilder‐Smith, O. H. G. (2013) · Cited by 7

Breakthrough pain: just pain?

Ballantyne, J. C. (2016) · Pain · doi:10.1097/j.pain.0000000000000684 · Cited by 7

Impact of Intravenous, Perioperative-Administrated Lidocaine on Postoperative Serum Levels of Endogenous Opioids in Children

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Opioids

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Correlated brain stem and cortical evoked responses to auditory tone change

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Imaging opioid analgesia in the human brain

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Effects of duloxetine, fluoxetine and pregabalin on fentanyl-induced hyperalgesia in rattus novergicus

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Neurophysiology of acute and chronic pain: from genes to pain symptoms

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Intractable Pain: Intoxication or Undermedication?

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Use of a buprenorphine-based pain management protocol is associated with reduced opioid requirements and pain on swallowing in oral mucositis: a retrospective cohort study

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Attention to Metaphor: From neurons to representations

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Farmacología de los opioides

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Role of buprenorphine in acute postoperative pain

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Efficacy of multimodal analgesic treatment of severe traumatic acute pain in mice pretreated with chronic high dose of buprenorphine inducing mechanical allodynia

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Opioid-Induced Hyperalgesia in Patients After Surgery

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Paroxysmal opioid-induced pain and hyperalgesia.

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Opioid-induced hyperalgesia

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Opioid-induced hyperalgesia: fact or fiction?

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