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Cited by 145Parasitic Infections and DiagnosticsViral gastroenteritis research and epidemiologyVeterinary medicine and infectious diseases

The DOI matches its Crossref record.

Treatment of intestinal microsporidiosis with albendazole in patients with AIDS

Blanshard, Christine, Ellis, David S., Tovey, D. George, Dowell, Stephanie, Gazzard, Brian G.·1992·AIDS
DOI 10.1097/00002030-199203000-00009
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Abstract

OBJECTIVE: To determine the clinical and parasitological response to treatment of intestinal microsporidiosis with albendazole. DESIGN: Open prospective study. SETTING: Hospital-based HIV/genito-urinary medicine unit. PATIENTS, PARTICIPANTS: Six consecutive AIDS patients with small intestinal microsporidiosis as the only identified cause of diarrhoea after intensive gastrointestinal investigations. RESULTS: Diarrhoea resolved completely in all patients within 1 week of starting treatment, and body weight stabilized or increased. Four patients who relapsed at 19-31 days after the cessation of treatment responded to a second course of albendazole. Degenerative changes occurred in the parasites after treatment, which had not been seen either in pre-treatment biopsies or, in four patients, following therapy with other drugs. CONCLUSIONS: Albenazole is a useful palliative treatment for microsporidial diarrhoea.

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Crossref · 10.1097/00002030-199203000-00009

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Authors
Blanshard, C., Ellis, D. S., Tovey, D. G., Dowell, S., & Gazzard, B. G.
Affiliations
London School of Hygiene & Tropical Medicine (GB)
ORCID
Blanshard, Christine
Venue
AIDS
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1992-03
Volume
6
Issue
3
Pages
311-314
ISSN
0269-9370 (ISSN-L)
DOI
10.1097/00002030-199203000-00009
OpenAlex
W2040860941
Cited by
145
References
0
Citations by year
2025: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 3 · 2014: 6
FWCI
14.25
Type
journal article
Language
en
Open access
closed
Locations
  • AIDS (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Parasitology › Parasitic Infections and Diagnostics
  • Health Sciences › Medicine › Infectious Diseases › Viral gastroenteritis research and epidemiology
  • Health Sciences › Veterinary › Small Animals › Veterinary medicine and infectious diseases
Keywords
intestinal microsporidiosis, albendazole, HIV-associated diarrhea, parasitological response, treatment relapse, palliative care
MeSH terms
Acquired Immunodeficiency Syndrome, Adult, Animals, Diarrhea, Humans, Male, Middle Aged, Prospective Studies, Albendazole, Microsporida, Microsporidiosis

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