The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Changing incidence of AIDS-defining illnesses in the era of antiretroviral combination therapy
Abstract
OBJECTIVE: To determine the incidence of AIDS-defining opportunistic infections and malignancies over a 5-year period from 1992 to 1996. STUDY POPULATION: Subcohort of 1003 homosexual men with HIV infection and CD4 count less than 200 x 10(6) cells/l from the Frankfurt AIDS Cohort Study. METHODS: Data including the earliest date that a CD4 T-lymphocyte count < 200 x 10(6)/l was reached and the dates of AIDS-defining events were compiled from medical records. Incidence analyses for AIDS-defining events and death during the subsequent 5 years (1992-1996) were performed using rates per 100 person-years of exposure. RESULTS: During the observation period, the number of patients per year with CD4 T-lymphocyte counts < 200 x 10(6)/l varied between 402 and 511. In 1992, 56.7% of patients experienced at least one AIDS-defining illness, and 20.7% in 1996. The annual number of AIDS-defining events per 100 patient-years of observation declined from 143.5 in 1992 to 38.3 in 1996, and the number of AIDS-related deaths fell from 25.7 to 12.9. Analysis of the number of events confirmed this trend for malignancies and single opportunistic infections, with the exception of mycobacterial diseases. CONCLUSIONS: The incidence of AIDS-defining events in patients with advanced HIV infection at Frankfurt University Hospital has declined by more than 70% from 1992 to 1996.
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Cites
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Cited by
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Self-citationLedergerber, B., Egger, M., Opravil, M., Telenti, A., Hirschel, B., Battegay, M., Vernazza, P., Sudre, P., Flepp, M., Furrer, H., et al. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01122-8 · Cited by 906
HIV-associated neurologic disease incidence changes: Multicenter AIDS Cohort Study, 1990–1998
Sacktor, N., Lyles, R. H., Skolasky, R., Kleeberger, C., Selnes, O. A., Miller, E. N., Becker, J. T., Cohen, B., McArthur, J. C., & Study*, T. M. A. C. (2001) · Neurology · doi:10.1212/wnl.56.2.257 · Cited by 591
HIV-associated cognitive impairment before and after the advent of combination therapy
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Cognitive Neuropsychology of HIV-Associated Neurocognitive Disorders
Woods, S. P., Moore, D. J., Weber, E., & Grant, I. (2009) · Neuropsychology Review · doi:10.1007/s11065-009-9102-5 · Cited by 573
Metadata
- Authors
- Brodt, H. R., Kamps, B. S., Gute, P., Knupp, B., Staszewski, S., & Helm, E. B.
- Venue
- AIDS
- Published
- 1997-11
- Volume
- 11
- Issue
- 14
- Pages
- 1731-1738
- ISSN
- 0269-9370 (ISSN-L)
- OpenAlex
- W2080704165
- Cited by
- 411
- References
- 14
- FWCI
- 27.47
- Type
- journal article
- Language
- en
- Open access
- closed
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