Cited by 166Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record.

NEURONAL DEGENERATION IN LOCUS CERULEUS AND CORTICAL CORRELATES OF ALZHEIMER DISEASE

Bondareff, W, Mountjoy, C Q, Roth, M, Rossor, M N, Iversen, L L, Reynolds, G P, Hauser, D L·1987·Alzheimer Disease & Associated Disorders

DOI 10.1097/00002093-198701040-00005

Open this paper in CoChat — free account

Abstract

Relationships were examined between neuronal degeneration in the nucleus locus ceruleus (nLC), a parameter of central noradrenergic impairment, and neocortical markers of Alzheimer disease (AD). The loss of nLC neurons was found to correlate significantly with norepinephrine concentration, choline acetyltransferase (ChAT) activity, and numbers of plaques and tangles on Brodmann area 24 (cingulate); ChAT and plaque counts in area 21 (temporal); and with ChAT activity in area 10 (frontal). In addition, nLC neuronal counts were correlated significantly with the severity and estimated duration of dementia. The number of neurofibrillary tangles in nLC, which did not correlate significantly with neocortical markers of AD, correlated with the estimated duration and severity of dementia. These data suggest that changes in central noradrenergic pathways are related to the pathophysiology of AD.

Integrity signals

Registry

Crossref · 10.1097/00002093-198701040-00005

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 101–165 of 165

Characterization of a mouse model overexpressing beta‐site APP‐cleaving enzyme 2 reveals a new role for BACE2
Azkona, G., Amador‐Arjona, A., Obradors‐Tarragó, C., Varea, E., Arqué, G., Pinacho, R., Fillat, C., de la Luna, S., Estivill, X., & Dierssen, M. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00538.x · Cited by 23
“a noradrenergic phenotype has also been reported in AD patients and in AD mouse models, where loss of locus coeruleus (LC) noradrenergic neurones (Bondareff et al. 1987; Kalinin et al. 2007; Mann 1983; O’Neil et al. 2007) may depend on the increase of APP C99.”
BackgroundResultInfluential
Noradrenergic Add-on Therapy with Extended-Release Guanfacine in Alzheimer’s Disease (NorAD): study protocol for a randomised clinical trial and COVID-19 amendments
Hoang, K., Watt, H., Golemme, M., Perry, R. J., Ritchie, C. W., Wilson, D., Pickett, J., Fox, C., Howard, R. J., & Malhotra, P. (2022) · Trials · doi:10.1186/s13063-022-06190-3 · Cited by 23
“Attentional processes are closely linked to brainstem arousal systems, particularly the locus coeruleus (LC), a noradrenergic/norepinephrine (NE) pontine nucleus with projections throughout the cerebral cortex [6].”
Background
Neuro-modulation, aminergic neuro-disinhibition and neuro-degeneration.
Schmitt, H. P. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2005.06.018 · Cited by 23
Acetylcholine and noradrenaline differentially regulate hippocampus-dependent spatial learning and memory
de Leo, G., Gulino, R., Coradazzi, M., & Leanza, G. (2022) · Brain Communications · doi:10.1093/braincomms/fcac338 · Cited by 20
Assessment of Memory Impairment in Early Diagnosis of Alzheimer’s Disease
Vyhnálek, M., Marková, H., Laczó, J., Béni, R. D., & Nuovo, S. D. (2019) · Current Alzheimer Research · doi:10.2174/1567205016666191113125303 · Cited by 17
Neuropathology of the Brainstem to Mechanistically Understand and to Treat Alzheimer’s Disease
Patthy, Á., Murai, J., Hanics, J., Pintér, A., Zahola, P., Hökfelt, T. G. M., Harkany, T., & Alpár, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10081555 · Cited by 17
“Obviously, cognitive decline caused by cortical failure is the most prominent sign of AD, both in its early [102] and later [103] stages.”
Background
Gender effect on the accumulation of hyperphosphorylated tau in the brain of locus-ceruleus-injured APP-transgenic mouse
Oikawa, N., Ogino, K., Masumoto, T., Yamaguchi, H., & Yanagisawa, K. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.11.005 · Cited by 19
Mouse strain and brain region‐specific expression of the glutaminyl cyclases QC and isoQC
Höfling, C., Indrischek, H., Höpcke, T., Waniek, A., Cynis, H., Koch, B. M., Schilling, S., Morawski, M., Demuth, H., Roßner, S., et al. (2014) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2014.05.008 · Cited by 20
“In particular, EWN and LC display profound neuronal loss (Bondareff et al., 1987; Rüb et al., 2001; Scinto et al., 1999, 2001).”
Background
2-pentadecyl-2-oxazoline prevents cognitive and social behaviour impairments in the Amyloid β-induced Alzheimer-like mice model: Bring the α2 adrenergic receptor back into play
Infantino, R., Boccella, S., Scuteri, D., Perrone, M., Ricciardi, F., Vitale, R. M., Bonsale, R., Parente, A., Allocca, I., Virtuoso, A., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113844 · Cited by 19
Tyr-Trp administration facilitates brain norepinephrine metabolism and ameliorates a short-term memory deficit in a mouse model of Alzheimer’s disease
Ichinose, T., Murasawa, H., Ishijima, T., Okada, S., Abe, K., Matsumoto, S., Matsui, T., & Furuya, S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0232233 · Cited by 20
“Morphological observations have revealed noradrenergic fiber degeneration in the locus coeruleus of many postmortem AD brains [6,7].”
Background
Increased Lymphocyte Dopamine β-Hydroxylase Immunoreactivity in Alzheimer’s Disease: Compensatory Response to Cholinergic Deficit?
Giubilei, F., Calderaro, C., Antonini, G., et al. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000080128 · Cited by 18
Changes in the locus coeruleus during the course of Alzheimer's disease and their relationship to cortical pathology
Beardmore, R., Durkin, M., Zayee‐Mellick, F., Lau, L. C., Nicoll, J. A. R., Holmes, C., & Boche, D. (2024) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12965 · Cited by 17
“Cell loss occurs early in the disease course with neuronal loss observed at the prodromal AD or mild cognitive impairment (MCI) stage [11] and is progressive, correlating with both cognitive impairment [12] and disease severity [13].”
Background
Spatial Analysis of the Neuronal Density of Aminergic Brainstem Nuclei in Primary Neurodegenerative and Vascular Dementia: A Comparative Immunocytochemical and Quantitative Study Using a Graph Method
Yang, Y. M., Beyreuther, K. T., & Schmitt, H. P. (1999) · Analytical Cellular Pathology · doi:10.1155/1999/256382 · Cited by 17
“Age-related neuron loss in non-demented controls was also found by other authors [16,21,44,91,93].”
Result
Decreased Orexin Receptor 1 mRNA Expression in the Locus Coeruleus in Both Tau Transgenic rTg4510 and Tau Knockout Mice and Accompanying Ascending Arousal System Tau Invasion in rTg4510
Keenan, R. J., Oberrauch, S., Bron, R., Nowell, C. J., Challis, L. M., Hoyer, D., & Jacobson, L. H. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-201177 · Cited by 15
Anti-Inflammatory Properties of Acetylcholinesterase Inhibitors Administred in Alzheimers Disease
Kamal, M. A., Greig, N. H., & Reale, M. (2009) · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry · doi:10.2174/187152309787580810 · Cited by 14
“These include defective amyloid protein metabolism [28, 29], abnormalities of glutamatergic [30], adrenergic, serotonergic and dopaminergic neurotransmission [31], and the potential involvement of some of the inflammatory markers, oxidative [32, 33] and hormonal pathways [34].”
Background
Decoding molecular mechanisms: brain aging and Alzheimer’s disease
Hayat, M., Syed, R. A., Qaiser, H., Uzair, M., Al-Regaiey, K., Khallaf, R. A., Albassam, L. A. M., Kaleem, I., Wang, X., Wang, R., et al. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01403 · Cited by 14
Eye pupil – a window into central autonomic regulation via emotional/cognitive processing
Ferencová, N., Višňovcová, Z., Olexova, L. B., & Tonhajzerová, I. (2021) · Physiological Research · doi:10.33549//physiolres.934749 · Cited by 75
The Locus Coeruleus – Noradrenaline system: Looking into Alzheimer’s therapeutics with rose coloured glasses
Behl, T., Kaur, I., Sehgal, A., Singh, S., Makeen, H. A., Albratty, M., Alhazmi, H. A., Bhatia, S., & BUNGAU, S. G. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113179 · Cited by 12
Assessing disease-modifying effects of norepinephrine in Down syndrome and Alzheimer’s disease
Ponnusamy, R., McNerney, M. W., Moghadam, S., & Salehi, A. (2017) · Brain Research · doi:10.1016/j.brainres.2017.09.035 · Cited by 11
Localization of amyloid beta peptides to locus coeruleus and medial prefrontal cortex in corticotropin releasing factor overexpressing male and female mice
Ross, J. A., Alexis, R., Reyes, B. A. S., Risbrough, V. B., & Bockstaele, E. J. V. (2019) · Brain Structure and Function · doi:10.1007/s00429-019-01915-8 · Cited by 12
Neurotransmitter changes in aging and dementia
Karlsson, I. (1993) · Nordic Journal of Psychiatry · doi:10.3109/08039489309102779 · Cited by 9
Immunohistochemical Demonstration of the pGlu79 α-Synuclein Fragment in Alzheimer’s Disease and Its Tg2576 Mouse Model
Bluhm, A., Schrempel, S., Schilling, S., von Hörsten, S., Schulze, A., Roßner, S., & Hartlage‐Rübsamen, M. (2022) · Biomolecules · doi:10.3390/biom12071006 · Cited by 8
Locus Coeruleus and Noradrenergic Pharmacology in Neurodegenerative Disease
Matt, R. A., Martin, R. S., Evans, A. K., Gever, J. R., Vargas, G. A., Shamloo, M., & Ford, A. P. D. W. (2023) · Handbook of experimental pharmacology · doi:10.1007/164_2023_677 · Cited by 11
Effects of Antidepressants on DSP4/CPT-Induced DNA Damage Response in Neuroblastoma SH-SY5Y Cells
Wang, Y., Hilton, B., Cui, K., & Zhu, M. (2015) · Neurotoxicity Research · doi:10.1007/s12640-015-9534-z · Cited by 8
“Furthermore, damage and loss of LC noradrenergic neurons are accelerated in AD (Mann and Yates 1983; Bondareff et al. 1987; German et al. 1992; Weinshenker 2008) and PD (Mann et al. 1983; Rommelfanger and Weinshenker 2007), representing an early pathological indicator of these diseases.”
Psychodynamic Perspectives in the Clinical Approach to Brain Disease in the Elderly
Cohen, G. D. (1989) · Springer eBooks · doi:10.1007/978-1-4684-1306-9_4 · Cited by 8
Noradrenaline Regulation of Brain-Body Communication
Fernandes, G., Lam, R. M., Park, J. H., Drummond, G. T., & Sur, M. (2025) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-89525-8_2 · Cited by 8
Chemoattractants and receptors in Alzheimer s disease
Le, Y. (2009) · Frontiers in Bioscience-Scholar · doi:10.2741/s81 · Cited by 7
Neurotoxin-Induced DNA Damage is Persistent in SH-SY5Y Cells and LC Neurons
Wang, Y., Musich, P. R., Cui, K., Zou, Y., & Zhu, M. (2015) · Neurotoxicity Research · doi:10.1007/s12640-015-9521-4 · Cited by 7
“…with the in vivo observations which demonstrate that degeneration of noradrenergic neurons may occur at an early stage in the brain of neurodegenerative disease patients (Bondareff et al. 1982; Mann and Yates 1983; Mann et al. 1983; Bondareff et al. 1987; German et al. 1992; Weinshenker 2008).”
BackgroundResultInfluential
CCL2 Induces the Production of β2 Adrenergic Receptors and Modifies Astrocytic Responses to Noradrenaline
Gutiérrez, I. L., González‐Prieto, M., García‐Bueno, B., Caso, J. R., Feinstein, D. L., & Madrigal, J. L. M. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-0960-9 · Cited by 7
Hyperinsulinemia Provokes Synchronous Increases in Central Inflammation and -Amyloid in Normal Adults
Fishel, M. A. (2005) · Archives of Neurology · doi:10.1001/archneur.62.10.1539 · Cited by 7
The Role of Metals in Alzheimer’s Disease
Hajji, N., Calvert, C., Ritchie, C. W., & Sastre, M. (2013) · Royal Society of Chemistry eBooks · doi:10.1039/9781849735896-00080 · Cited by 7
Repetition priming and cortical arousal in healthy aging and Alzheimer's disease
Kane, A. E., Festa, E. K., Salmon, D. P., & Heindel, W. C. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.02.024 · Cited by 6
Progress in PET Imaging of the Norepinephrine Transporter System
Ding, Y. (2014) · Springer eBooks · doi:10.1007/978-3-642-42014-6_19 · Cited by 6
Neuropathological Correlates of Dementia in Alzheimer’s Disease
Masliah, E., & Salmon, D. P. (1999) · Cerebral cortex · doi:10.1007/978-1-4615-4885-0_15 · Cited by 5
The impact of age and Alzheimer’s disease on locus coeruleus mediated neuromodulation of neural circuits and goal-directed behaviorPreprint
Joshi, S. (2023) · PsyArXiv (OSF Preprints) · doi:10.31234/osf.io/bqwte · Cited by 5
Noradrenaline, Astroglia, and Neuroinflammation
Madrigal, J. L. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805088-0.00014-1 · Cited by 4
Noradrenergic depletion causes sex specific alterations in the endocannabinoid system in the Murine prefrontal cortex
Urquhart, M. A., Ross, J. A., Reyes, B. A. S., Nitikman, M., THOMAS, S. A., Mackie, K., & Bockstaele, E. J. V. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100164 · Cited by 4
“, 2016) and AD (Tomlinson et al., 1981; Bondareff et al., 1987; Forstl et al., 1992; Zarow et al., 2003; Chalermpalanupap et al., 2013; Takahashi et al., 2015), and resultant alterations in NE transmission and signaling (Wyatt et al.”
Progress in PET Imaging of the Norepinephrine Transporter System
Ding, Y. (2020) · Springer eBooks · doi:10.1007/978-3-030-53176-8_20 · Cited by 5
The locus coeruleus, a blue spot for early diagnosis and prognosis of Alzheimer’s disease
Farahani, F., Anaclet, C., Azizi, H., & Gompf, H. S. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1632236 · Cited by 4
Visual Cognition in Alzheimer’s Disease and Its Functional Implications
Philip, C., & Ally, B. A. (2011) · InTech eBooks · doi:10.5772/18890 · Cited by 3
Neurobiologische Aspekte psychischer Störungen bei degenerativen Hirnerkrankungen im Alter
Roth, M., & Mountjoy, C. Q. (1989) · Springer eBooks · doi:10.1007/978-3-642-71825-0_3 · Cited by 3
Self-citation
Diminishing accelerated long-term forgetting in mild cognitive impairment: Study protocol for a prospective, double-blind, placebo-controlled, randomized controlled trial
Adcock, K. S., LAWLOR, B. A., Robertson, I. H., & Vanneste, S. (2022) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2022.100989 · Cited by 3
Behavioral correlates of presynaptic events in the cholinergic neurotransmitter system
Russell, R. W. (1988) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-9154-7_3 · Cited by 3
Immune Challenge Alters Reactivity of Hippocampal Noradrenergic System in Prenatally Stressed Aged Mice
Grigoryan, G., Lonnemann, N., & Körte, M. (2019) · Neural Plasticity · doi:10.1155/2019/3152129 · Cited by 3
“In Alzheimer’s disease, it correlates with the degree of deposition of amyloid plaques and neurofibrillary tangles as well as with the severity of cognitive deficits both in mouse models and in human Alzheimer’s patients [79, 81, 82].”
Background
Biopsychiatry in Alzheimer’s Disease
Cohen, G. D. (1990) · Annual Review of Gerontology and Geriatrics · doi:10.1007/978-3-662-40455-3_7 · Cited by 3
Functional properties of microglia in mouse models of Alzheimer’s disease
Saiepour, N. (2017) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-6117 · Cited by 3
Impact of early locus coeruleus lesions in the TgF344 Alzheimer's disease rat model
Marriott, A., Schroeder, J. P., Korukonda, A., Pate, B. S., McCann, K. E., Weinshenker, D., & Kelberman, M. A. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71334 · Cited by 2
“3,14 Based on this evidence, studies have used the selective LC neuro-toxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride (DSP-4) to isolate phenotypes related to LC dysfunction and degeneration in neurodegenerative disorders.”
A 3D Graph-Cut based Algorithm for Evaluating Carotid Plaque Echogenicity and Texture
Seabra, J., & Sanches, J. (2009) · InTech eBooks · doi:10.5772/7459 · Cited by 2
Expressions of depression in Alzheimer's disease. The current scientific debate
Balestrieri, M. (2000) · Epidemiologia e Psichiatria Sociale · doi:10.1017/s1121189x00008319 · Cited by 2
“…tutti gli studi la perdita neuronale nel LC era correlata ad una maggiore gravita dell'AD, ad una sua insorgenza piu precoce e ad un esito piu rapido, suggerendo cosi l'esistenza di due tipi diversi di AD, uno piu lieve ed uno con le caratteristiche teste descritte (Bondareff et al, 1987).”
Background
Synergetic effect of a DSP4-induced locus coeruleus lesion and systemic LPS exacerbates substantia nigra dopaminergic neuron loss
Şimşek, F., Papová, D., Henriksson, E., Olmedo‐Díaz, S., Blyberg, M., El‐Habta, R., Virel, A., & af Bjerkén, S. (2025) · Scientific Reports · doi:10.1038/s41598-025-33147-8 · Cited by 1
Greater locus coeruleus vulnerability in atypical clinicopathologic forms of Alzheimer's disease
Dunlop, S. R., Matchett, B. J., Mannsbart, A., Al‐Shaikh, F. S. H., Peng, Z., Rothberg, D. M., Tranovich, J. F., Duara, R., Vélez-Uribe, I., Gondrez, J., et al. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71140 · Cited by 1
Glucose Metabolism and Insulin Action in Alzheimer’s Disease Pathogenesis
Bosco, D., Plastino, M., Spano, A. L., Ermio, C., & Fav, A. (2011) · InTech eBooks · doi:10.5772/23138 · Cited by 1
The Association between Exposure to Fine Particulate Matter and MRI-Assessed Locus Coeruleus Integrity in the Vietnam Era Twin Study of Aging (VETSA)
Puckett, O. K., Fennema‐Notestine, C., Hagler, D. J., Braskie, M. N., Chen, J., Finch, C. E., Kaufman, J. D., Petkus, A. J., Reynolds, C. A., Salminen, L. E., et al. (2024) · Environmental Health Perspectives · doi:10.1289/ehp14344 · Cited by 2
Faculty Opinions recommendation of Noradrenergic depletion potentiates beta -amyloid-induced cortical inflammation: implications for Alzheimer's disease.
Aston‐Jones, G. (2002) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1005500.65458 · Cited by 1
P11467: An Orally-Active Acetylcholinesterase Inhibitor and α2-Adrenoceptor Antagonist for Alzheimer’s Disease
Vargas, H. M., Smith, C. P., Li, M., Bores, G. M., Giovanni, A., Zhou, L., Cunningham, D., Brooks, K. M., Camacho, F., Winslow, J., et al. (1997) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4612-4116-4_37
A Comprehensive Study of the Effects of Neurotoxins on Noradrenergic Phenotypes, Neuronal Responses and Potential Intervention by Antidepressants in Noradrenergic Cells
Wang, Y. (2014) · Digital Commons - East Tennessee State University (East Tennessee State University)
The alpha2C-adrenoceptor as a neuropsychiatric drug tar-get - PET studies in human subjects
Lehto, J. (2015) · UTUPub (University of Turku)
New genetic mouse models for neurodegenerative diseases: Contribution of noradrenaline to Alzheimer’s disease pathogenesis and creation of a new genetic model for Parkinson’s disease.
Hernandez, A. C. M. (2011) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-3555
Ambient Air Pollution Exposure is Associated with Lower Mri-Assessed Locus Coeruleus IntegrityPreprint
Puckett, O. K., Fennema‐Notestine, C., Hagler, D. J., Braskie, M. N., Chen, J., Finch, C. E., Kaufman, J. D., Petkus, A. J., Salminen, L. E., Thompson, P. M., et al. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4565839
Control of pupil responses
Joshi, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-820480-1.00077-2 · Cited by 1
Impaired sleep microarchitecture is associated with locus coeruleus degeneration in Parkinson's disease
Doppler, C. E. J., Sembowski, N., Plottka, D., Hommelsen, M., Röttgen, S., Schwabedal, J. T. C., Schreiner, S. J., Fink, G. R., Borghammer, P., Bialonski, S., et al. (2026) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2026.108339 · Cited by 1
Additional file 1 of IL-1β and TNF-α play an important role in modulating the risk of periodontitis and Alzheimer’s disease
Wang, R. P., Huang, J., Chan, K. W. Y., Leung, W. K., Goto, T., Ho, Y.-S., & Chang, R. C.-C. (2024) · Figshare · doi:10.6084/m9.figshare.26574926
Impaired LC-NE System—A Novel Molecular Mechanism Underlying Health Disparity and Increased Prevalence of Alzheimer’s Disease Among African Americans
Ding, Y., Pirraglia, E., Wang, J., Mikheev, A., Chen, J., Rusinek, H., & Babb, J. S. (2026) · Diagnostics · doi:10.3390/diagnostics16020190
“Postmortem studies suggest that the loss of LC neurons better predicts the onset and severity of clinical symptoms of AD than A β plaques, NFTs, or degeneration in other brain regions [42–47].”
Pretangle tau pathology accrual in the default mode network during the progression of Alzheimer’s disease
Kara, B., Kelly, I. M., Beck, J. S., Kuhn, N. C., Mufson, E. J., Vega, I. E., Kanaan, N. M., & Counts, S. (2026) · Molecular Neurodegeneration Advances · doi:10.1186/s44477-026-00019-y
“Moreover, the DMN hubs also receive extensive innervation from cholinergic basal forebrain [103, 104] and brainstem noradrenergic [105, 106] and serotin-ergic [107] neurons that modulate memory and attentional behaviors [108].”
Locus Coeruleus as a Master Regulator of Diverse Functions in the Central Nervous System: Its Relevance in Ageing and Neurodegenerative Disorders
Bhattacharya, A., Manjithaya, R. R., Chickabasaviah, Y. T., & Alladi, P. A. (2026) · Annals of Neurosciences · doi:10.1177/09727531261462296

Authors: Bondareff, W., Mountjoy, C. Q., Roth, M., Rossor, M. N., Iversen, L. L., Reynolds, G. P., & Hauser, D. L.
Affiliations: University of Southern California (US)
University of Cambridge (GB)
Medical Research Council (GB)
ORCID: Rossor, M N
Reynolds, G P
Venue: Alzheimer Disease & Associated Disorders
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1987
Volume: 1
Issue: 4
Pages: 256-262
ISSN: 0893-0341 (ISSN-L)
DOI: 10.1097/00002093-198701040-00005
OpenAlex: W2053273884
Cited by: 166
References: 0
Citations by year: 2026: 6 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 10 · 2021: 7 · 2020: 9 · 2019: 6 · 2018: 6 · 2017: 11 · 2016: 6 · 2015: 7 · 2014: 7 · 2013: 4 · 2012: 4
FWCI: 1.60
Type: journal article
Language: en
Open access: closed
Locations: Alzheimer Disease & Associated Disorders (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Alzheimer's disease, locus coeruleus, neurodegeneration, noradrenergic pathways, norepinephrine, choline acetyltransferase, amyloid plaques, neurofibrillary tangles, dementia severity, neocortex, cingulate cortex, temporal cortex, frontal cortex
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Cell Count, Cerebral Cortex, Choline O-Acetyltransferase, Humans, Locus Coeruleus, Nerve Degeneration, Neurofibrils, Neurons, Norepinephrine

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

NEURONAL DEGENERATION IN LOCUS CERULEUS AND CORTICAL CORRELATES OF ALZHEIMER DISEASE

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks