Decreased corticosteroid-binding globulin in burn patients: Relationship with interleukin-6 and fat in nutritional support
Abstract
Objectives To analyze the effect of low-fat nutritional solutions, with or without fish oil, on serum interleukin (IL)-6, and to explore the relationships between IL-6, corticosteroid-binding globulin (CBG; the main cortisol carrier in plasma), and protein metabolism in severely burned adult patients. Design Randomized, double-blind study with control and low fat-fed groups. Setting Burn center of Hôtel-Dieu Hospital of Montréal. Patients Thirty-seven men and women with thermal burn injury over >20% of body surface area and no other known medical condition. Interventions Within 24 hrs after admission, nutritional support was started through a gastroenteral tube inserted under endoscopic guidance. The goal for energy intake was calculated using the Curreri formula, and was adjusted with biweekly measurements of resting energy expenditure. Patients were randomly assigned to one of the following groups: control (35% of energy as fat); low fat 1 (15% of energy as fat); and low fat 2 (50% of fat in the form of fish oil). Measurements and main results Tumor necrosis factor (TNF)-alpha and TNF-beta, IL-6, CBG, and cortisol free fraction were measured every 3 days for 28 days. Nitrogen balance and urinary 3-methylhistidine excretion were measured daily. IL-6 concentrations were high in all patients, with the highest value (460 +/- 111 units/mL) observed on day 4. Concentrations of IL-6 were higher in control patients than in low fat-fed patients between days 13 and 28, but not betwee…
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Cytokines, including IL-6, have been shown to inhibit CBG production.
“Cytokines, including IL-6, have been shown to inhibit CBG production”
From Cytokines and Glucocorticoid Receptor Signaling (2009) · cites this paper as [81]
Cytokine-induced decreases in CBG are believed to play a role in the decreased levels of CBG seen in septic shock and burn patients.
“cytokine-induced decreases in CBG are believed to play a role in the decreased levels of CBG seen in septic shock and burn patients.81,82”
From Cytokines and Glucocorticoid Receptor Signaling (2009) · cites this paper as [81]
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- Authors
- Bernier, J., Jobin, N., Emptoz-Bonneton, A., Pugeat, M. M., & Garrel, D. R.
- Affiliations
- Centre Hospitalier de l’Université de Montréal (CA)
- Lyon 1 Université (FR)
- ORCID
- Bernier, Jacques
- Venue
- Critical Care Medicine
- Published
- 1998-03
- Volume
- 26
- Issue
- 3
- Pages
- 452-460
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W2088217904
- Cited by
- 81
- References
- 0
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 1 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 4 · 2013: 2 · 2012: 4
- FWCI
- 2.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- EspaceINRS (National Institute for Scientific Research (Canada)) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Burn Injury Management and Outcomes
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- corticosteroid-binding globulin, interleukin-6, burns, fish oil, cortisol, TNF-α, lymphotoxin, nitrogen balance, 3-methylhistidine, protein metabolism, sepsis, hepatic protein synthesis, cytokines, critically ill patients, enteral nutrition, sepsis risk prediction, prognostic factors
- MeSH terms
- Adult, Burns, Energy Intake, Dietary Fats, Double-Blind Method, Enteral Nutrition, Female, Fish Oils, Food, Formulated, Humans, Hydrocortisone, Lymphotoxin-alpha, Male, Methylhistidines, Nitrogen, Parenteral Nutrition, Transcortin, Tumor Necrosis Factor-alpha, Interleukin-6
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