The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Proteolytic Cascade Enzymes Increase in Focal Cerebral Ischemia in Rat
Abstract
Cerebral infarction initiates a cascade of molecular events, leading to proteolytic cell death. Matrix-degrading metalloproteinases (MMPs) are neutral proteases involved in extracellular matrix damage. Type IV collagenase is an MMP that increases cerebral capillary permeability after intracerebral injection and may be important along with plasminogen activators (PA) in secondary brain edema in stroke. Therefore, we measured MMPs and PAs in spontaneously hypertensive (SHR) or Wistar-Kyoto (WKY) rats with permanent middle cerebral artery occlusion (MCAO). Brain tissue was assayed for MMPs and PAs at 1, 3, 12, and 24 h and 5 days after occlusion, using substrate gel Polyacrylamide electrophoresis (zymography). SHR showed an increase in 92-kDa type IV collagenase (gelatinase B) in the infarcted hemisphere compared with the opposite side at 12 and 24 h ( p < 0.05). Gelatinase A remained the same in both infarcted and normal tissue until 5 days after injury, when it increased significantly ( p < 0.05). Urokinase-type PA was increased significantly at 12 and 24 h and 5 days, while tissue-type PA was decreased significantly at 1, 12, and 24 h in the ischemic compared with the nonischemic hemisphere. Gelatinase B was markedly increased in SHR at 12 and 24 h compared with WKY ( p < 0.05). Secondary vasogenic edema is maximal 1–2 days after a stroke, which is the time that gelatinase B was elevated. The time of appearance of gelatinase B suggests a role in secondary tissue damage and vasogenic edema, while gelatinase A may be involved in tissue repair.
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Citations
Cites
Matrix metalloproteinases and their inhibitors in connective tissue remodeling
Woessner, J. F. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.8.1850705 · Cited by 3,282
Folkman, J., & Shing, Y. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49853-0 · Cited by 2,654
Metastatic potential correlates with enzymatic degradation of basement membrane collagen
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Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage
Choi, D. W. (1988) · Trends in Neurosciences · doi:10.1016/0166-2236(88)90200-7 · Cited by 1,736
Siesjö, B. K., & Bengtsson, F. (1989) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1989.20 · Cited by 1,231
Tumor necrosis factor-alpha expression in ischemic neurons.
Liu, T., Clark, R. K., McDonnell, P. C., Young, P. R., White, R. F., Barone, F. C., & Feuerstein, G. Z. (1994) · Stroke · doi:10.1161/01.str.25.7.1481 · Cited by 797
Self-citationProlonged activation of jun and collagenase genes by tumour necrosis factor-α
Brenner, D. A., O'Hara, M., Angel, P., Chojkier, M., & Karin, M. (1989) · Nature · doi:10.1038/337661a0 · Cited by 717
Sato, H., & Seiki, M. (1993) · PubMed · Cited by 695
Nitric Oxide Synthase Inhibition and Cerebrovascular Regulation
Iadecola, C., Pelligrino, D. A., Moskowitz, M. A., & Lassen, N. A. (1994) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1994.25 · Cited by 652
Collagenase-induced intracerebral hemorrhage in rats.
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Self-citation
Cited by
Yang, Y., Estrada, E. Y., Thompson, J. F., Liu, W., & Rosenberg, G. A. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600375 · Cited by 1,060
Self-citationAsahi, M., Wang, X., Mori, T., Sumii, T., Jung, J.-C., Moskowitz, M. A., Fini, M. E., & Lo, E. H. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07724.2001 · Cited by 1,004
Tumor Necrosis Factor-α: A Mediator of Focal Ischemic Brain Injury
Barone, F. C., Arvin, B., White, R. F., Miller, A., Webb, C. L., Willette, R. N., Lysko, P. G., & Feuerstein, G. Z. (1997) · Stroke · doi:10.1161/01.str.28.6.1233 · Cited by 863
Self-citationRosenberg, G. A., Estrada, E. Y., & Dencoff, J. E. (1998) · Stroke · doi:10.1161/01.str.29.10.2189 · Cited by 861
Self-citationMatrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers
Rempe, R. G., Hartz, A. M., & Bauer, B. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16655551 · Cited by 721
Metadata
- Authors
- Rosenberg, G. A., Navratil, M., Barone, F., & Feuerstein, G.
- Venue
- Journal of Cerebral Blood Flow & Metabolism
- Publisher
- SAGE Publications
- Published
- 1996-05
- Volume
- 16
- Issue
- 3
- Pages
- 360-366
- ISSN
- 0271-678X (ISSN-L)
- 1559-7016
- OpenAlex
- W1990711278
- Cited by
- 403
- References
- 28
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rosenberg, G. A., Navratil, M., Barone, F., & Feuerstein, G. (1996). Proteolytic Cascade Enzymes Increase in Focal Cerebral Ischemia in Rat. Journal of Cerebral Blood Flow & Metabolism. https://doi.org/10.1097/00004647-199605000-00002
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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