Global Forebrain Ischemia Results in Differential Cellular Expression of Interleukin-1β (IL-1β) and its Receptor at mRNA and Protein Level

Sairanen, Tiina R.; Lindsberg, Perttu J.; Brenner, Michael; Sirén, Anna-Leena

doi:10.1097/00004647-199710000-00013

Global Forebrain Ischemia Results in Differential Cellular Expression of Interleukin-1β (IL-1β) and its Receptor at mRNA and Protein Level

The mRNA expression of the proinflammatory cytokine interleukin-1beta (IL-1beta) has been shown to be induced in neural elements during ischemia. It is not clear which cells generate the IL-1beta mRNA and eventually synthesize IL-1 protein and which cells respond to this signaling by producing IL…