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A FLUORINATED GLUCOSE ANALOG, 2-FLUORO-2-DEOXY-D-GLUCOSE (F-18): NONTOXIC TRACER FOR RAPID TUMOR DETECTION
Abstract
Rapid uptake of F-18 FDG was observed in a variety of transplanted and spontaneous tumors in animals. The tumor uptake reached a peak by 30 min and remained relatively constant up to 60 min, with a very slow wash-out of F-18 activity from the tumor thereafter. Tumor-to-normal tissue and tumor-to-blood ratios ranged from 2.10-9.15 and 2.61-17.82, respectively, depending on the type of tumor. A scintiscan of a seminoma in a dog showed very high uptake in the viable part and lack of uptake in the necrotic mass. Toxicological studies in mice using 1000 times human tracer dose (HTD) per wk for 3 wk and in dogs using 50 times HTD per wk for 3 wk did not show any evidence of acute or chronic toxicity.
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Citations
Cited by
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Positron emission tomography scanning in the evaluation of hepatocellular carcinoma
Khan, M. A., Combs, C. S., Brunt, E. M., Lowe, V. J., Wolverson, M. K., Solomon, H., Collins, B. T., & Bisceglie, A. M. D. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80248-2 · Cited by 417
Fluorodeoxyglucose PET imaging in the evaluation of gallbladder carcinoma and cholangiocarcinoma
Anderson, C. D., Rice, M. H., Pinson, C. W., Chapman, W. C., Chari, R. S., & Delbeke, D. (2004) · Journal of Gastrointestinal Surgery · doi:10.1016/j.gassur.2003.10.003 · Cited by 377
Metabolic positron emission tomography imaging in cancer detection and therapy response
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Metadata
- Authors
- Som, P., Atkins, H. L., Bandoypadhyay, D., Fowler, J. S., MacGregor, R. R., Matsui, K., Oster, Z. H., Sacker, D. F., Shiue, C. Y., Turner, H., Wan, C. N., Wolf, A. P., & Zabinski, S. V.
- Venue
- Journal of Computer Assisted Tomography
- Published
- 1980-12
- Volume
- 4
- Issue
- 6
- Pages
- 878
- ISSN
- 0363-8715 (ISSN-L)
- OpenAlex
- W2117305340
- Cited by
- 504
- References
- 0
- FWCI
- 3.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A FLUORINATED GLUCOSE ANALOG, 2-FLUORO-2-DEOXY-D-GLUCOSE (F-18): NONTOXIC TRACER FOR RAPID TUMOR DETECTION. https://app.cochat.ai/papers/10.1097/00004728-198012000-00045
- The paper
- Som, P., Atkins, H. L., Bandoypadhyay, D., Fowler, J. S., MacGregor, R. R., Matsui, K., Oster, Z. H., Sacker, D. F., Shiue, C. Y., Turner, H., Wan, C. N., Wolf, A. P., & Zabinski, S. V. (1980). A FLUORINATED GLUCOSE ANALOG, 2-FLUORO-2-DEOXY-D-GLUCOSE (F-18): NONTOXIC TRACER FOR RAPID TUMOR DETECTION. Journal of Computer Assisted Tomography. https://doi.org/10.1097/00004728-198012000-00045
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
