The DOI matches its Crossref record.
Fluoxetine in Major Depression: Efficacy, Safety and Effects on Sleep Polygraphic Variables
Abstract
Fluoxetine (60 mg), a selective inhibitor of the reuptake of 5-HT, was compared in a double-blind trial to amitriptyline (150 mg) in a sample of 34 patients fitting the Research Diagnostic Criteria for a major depressive disorder. Patients were studied after a drug washout period of 10 days and an active treatment period of 42 days. Sleep polygraphic recordings were performed before and at the end of the study. As indicated by the significant decrease in the Hamilton Depression scale and the Montgomery Asberg Depression scale, fluoxetine showed similar antidepressant effects to amitriptyline with significantly fewer adverse effects. Fluoxetine and amitriptyline decreased the amount of REM sleep, a well known effect of classical antidepressants. Fluoxetine showed some specific effects on sleep continuity (potentially dose related) as indicated by the significant increase in the number of awakenings and in stage shifts, without interfering with the therapeutic response.
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Amitriptyline (150mg) and fluoxetine (60mg) both produced significant REM sleep suppression.
“(Kerkhofs et al., 1990) demonstrated that amitriptyline (150mg) and fluoxetine (60mg) both produced significant REM sleep suppression.”
From Antidepressants and their effect on sleep (2005) · cites this paper as Kerkhofs et al., 1990
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Anderson, I. M. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(99)00092-0 · Cited by 940
Antidepressants and their effect on sleep
Mayers, A. G., & Baldwin, D. S. (2005) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.726 · Cited by 323
Depression, sleep physiology, and antidepressant drugs
Winokur, A., Gary, K. A., Rodner, S., Rae-Red, C., Fernando, A. T., & Szuba, M. P. (2001) · Depression and Anxiety · doi:10.1002/da.1043 · Cited by 179
Goldstein, B. J., & Goodnick, P. J. (1998) · Journal of Psychopharmacology · doi:10.1177/0269881198012003041 · Cited by 171
Metadata
- Authors
- KERKHOFS, M., RIELAERT, C., MAERTELAER, V. D., LINKOWSKI, P., CZARKA, M., & MENDLEWICZ, J.
- Affiliations
- Erasmus Hospital (BE)
- Université Libre de Bruxelles (BE)
- Venue
- International Clinical Psychopharmacology
- Published
- 1990-10
- Volume
- 5
- Issue
- 4
- Pages
- 253-260
- ISSN
- 0268-1315 (ISSN-L)
- OpenAlex
- W2060954042
- Cited by
- 61
- References
- 0
- Citations by year
- 2025: 1 · 2022: 1 · 2016: 4 · 2015: 1 · 2014: 1 · 2013: 1
- FWCI
- 1.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Clinical Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- fluoxetine, amitriptyline, major depressive disorder, selective serotonin reuptake inhibitors, tricyclic antidepressants, REM sleep reduction, sleep continuity, sleep awakenings, adverse drug reactions, antidepressant efficacy
- MeSH terms
- Adolescent, Adult, Amitriptyline, Depression, Female, Fluoxetine, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Sleep
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