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Impulsive aggression and central serotonergic system function in humans: an example of a dimensional brain-behavior relationship
Abstract
A dimensional relationship between central serotonergic (5-HT) system function and indices of suicidal and impulsive aggressive behaviors has been suggested by more than a decade of research in patients with psychiatric disorders. This paper reviews a series of studies conducted in healthy male individuals and in male patients with major mood and/or personality disorder involving pharmacochallenge and neurochemical strategies designed to explore the role of central 5-HT system function in the regulation of suicidal and impulsive aggressive behavior in humans. The results of these studies suggest that reduced overall central 5-HT function in the limbic-hypothalamic system is associated with suicidal and/or impulsive aggressive behaviors in patients with major mood and/or personality disorders and that diminished 5-HT post-synaptic receptor function in this brain region may be an important biological correlate of these behaviors.
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Cited by
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Swaab, D. F., Bao, A.-M., & Lucassen, P. J. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2005.03.003 · Cited by 984
Selective Alteration of Personality and Social Behavior by Serotonergic Intervention
Knutson, B., Wolkowitz, O. M., Cole, S. W., Chan, T., Moore, E. A., Johnson, R. C., Terpstra, J., Turner, R. A., & Reus, V. I. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.3.373 · Cited by 500
van Praag, H. M. (2004) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2004.05.031 · Cited by 377
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Metadata
- Authors
- Coccaro, E. F.
- Venue
- International Clinical Psychopharmacology
- Published
- 1992
- Volume
- 7
- Issue
- 1
- Pages
- 3-12
- ISSN
- 0268-1315 (ISSN-L)
- OpenAlex
- W2074831193
- Cited by
- 220
- References
- 0
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- closed
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