The DOI matches its Crossref record.
Sleep and Paroxetine: A Comparison with Mianserin in Elderly Depressed Patients
Abstract
A total of 60 patients aged 65 years and over who were suffering from unipolar depression were entered into a double-blind 6-week comparative study of paroxetine and mianserin. Assessments of efficacy of treatment included the Hamilton Depression Rating Scale, Clinical Global Impression, and the Leeds Sleep Evaluation Questionnaire. The results showed that the two drugs had equal and acceptable clinical efficacy. There was a similar overall incidence of spontaneously reported adverse events, but with clearly different profiles and a suggestion that mianserin was associated with more anticholinergic effects. In terms of sleep, the study provided evidence of a more beneficial effect from paroxetine.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
LSEQ scores were significantly more likely to be improved with paroxetine (15mg) than mianserin (30mg); paroxetine was significantly improved from baseline on all four factors; mianserin only for BFW.
“(Dorman, 1992) demonstrated that LSEQ scores were significantly more likely to be improved with paroxetine (15mg) than mianserin (30mg); paroxetine was significantly improved from baseline on all four factors; mianserin only for BFW.”
From Antidepressants and their effect on sleep (2005) · cites this paper as Dorman, 1992
In elderly depressed patients, paroxetine 15mg significantly improved 6 out of 10 LSEQ scores compared to mianserin 30mg (p<.05).
“6 out of 10 LSEQ scores sig improved PAR, 1 factor sig increased MIA (p<.05); 4 of factors worsened MIA, mostly re poorer waking (ns)”
From Antidepressants and their effect on sleep (2005) · cites this paper as Dorman, 1992
In elderly depressed patients, mianserin 30mg worsened 4 LSEQ factors, mostly regarding poorer waking, but not significantly.
“6 out of 10 LSEQ scores sig improved PAR, 1 factor sig increased MIA (p<.05); 4 of factors worsened MIA, mostly re poorer waking (ns)”
From Antidepressants and their effect on sleep (2005) · cites this paper as Dorman, 1992
In elderly depressed patients, mianserin 30mg significantly increased 1 LSEQ factor (p<.05).
“6 out of 10 LSEQ scores sig improved PAR, 1 factor sig increased MIA (p<.05); 4 of factors worsened MIA, mostly re poorer waking (ns)”
From Antidepressants and their effect on sleep (2005) · cites this paper as Dorman, 1992
Citations
Cited by
Sorted by citations
Selective serotonin reuptake inhibitors: meta-analysis of efficacy and acceptability.
Song, F., Freemantle, N., Sheldon, T. A., House, A., Watson, P., Long, A., & Mason, J. (1993) · BMJ · doi:10.1136/bmj.306.6879.683 · Cited by 399
Antidepressants and their effect on sleep
Mayers, A. G., & Baldwin, D. S. (2005) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.726 · Cited by 323
Papakostas, G. I., Thase, M. E., Fava, M., Nelson, J. C., & Shelton, R. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.027 · Cited by 308
Kok, R. M., Nolen, W. A., & Heeren, T. J. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.02.036 · Cited by 167
Krause, M., Gutsmiedl, K., Bighelli, I., Schneider-Thoma, J., Chaimani, A., & Leucht, S. (2019) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2019.07.130 · Cited by 65
Metadata
- Authors
- DORMAN, T.
- Affiliations
- Stoke Mandeville Hospital (GB)
- Corresponding author
- DORMAN, T.
- Venue
- International Clinical Psychopharmacology
- Published
- 1992-06
- Volume
- 6
- Pages
- 5-58
- ISSN
- 0268-1315 (ISSN-L)
- OpenAlex
- W1964450221
- Cited by
- 41
- References
- 0
- Citations by year
- 2019: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Clinical Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- paroxetine, mianserin, major depressive disorder, older adults, sleep, antidepressant efficacy, adverse events, anticholinergic effects, selective serotonin reuptake inhibitors, tricyclic antidepressants
- MeSH terms
- Aged, Aging, Depressive Disorder, Double-Blind Method, Humans, Mianserin, Psychiatric Status Rating Scales, Sleep, Paroxetine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
