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Efficacy of amineptine in the prevention of relapse in unipolar depression
Abstract
The clinical properties of amineptine, a mainly dopaminergic antidepressant, were assessed in a double-blind controlled study involving patients fulfilling Diagnostic and Statistical Manual of Mental Disorders (DSM-III) criteria for unipolar depression. The aim was to determine how relapses could be prevented in this frequently recessing disorder. The study was a two-phase, 12-month, multicentre trial of patients suffering from major depression or dysthymia, diagnosed using DSM-III criteria and evaluated on the Montgomery-Asberg Depression Rating Scale and the Mood, Anxiety, Retardation, Danger scale. Phase I was an open-label 3-month period, with the patients being given 200 mg amineptine per day. The second, 9-month period was a placebo-controlled prophylactic phase. A total of 458 patients were initially included in the study. Of the 376 who completed phase I, 303 (66%) were responders; 284 entered the prophylactic study, randomly assigned to two groups. Of the 134 patients in the placebo group who completed phase II, 25 (18.7%) suffered a relapse, compared with nine out of the 136 (6.6%) in the amineptine group. After resolution of an acute episode of major depression or dysthymia, long-term antidepressant therapy with amineptine significantly reduced the relapse rate.
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“Despite generally effective short-term treatments for acute episodes of major depression, many patients experience relapses (early return of symptoms within the expected duration of a current episode, of perhaps 3–12 months) or later recurrences (new episodes) following initial short-term improvement or remission (Georgotas 1985; Ferreri et al., 1997; Forte et al., 2015).”
From Prevention of Relapse and Recurrence in Adults with Major Depressive Disorder: Systematic Review and Meta-Analyses of Controlled Trials (2016) · cites this paper as Ferreri et al., 1997
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Metadata
- Authors
- Ferreri, M., Colonna, L., & Leger, J.-M.
- Affiliations
- Hôpital Saint-Antoine (FR)
- Centre Hospitalier Esquirol de Limoges (FR)
- Corresponding author
- Ferreri, Maurice
- Venue
- International Clinical Psychopharmacology
- Published
- 1997-07
- Volume
- 12
- Pages
- S39
- ISSN
- 0268-1315 (ISSN-L)
- OpenAlex
- W2095421870
- Cited by
- 10
- References
- 0
- Citations by year
- 2015: 1
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Clinical Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- amineptine, major depressive disorder, relapse prevention, prophylaxis, dysthymia
- MeSH terms
- Adult, Antidepressive Agents, Tricyclic, Depressive Disorder, Dibenzocycloheptenes, Double-Blind Method, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Recurrence, Treatment Outcome
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