Cited by 178Substance Abuse Treatment and OutcomesBipolar Disorder and TreatmentPersonality Disorders and Psychopathology

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Psychopathology in Cocaine Abusers: Changing Trends

WEISS, ROGER D., MIRIN, STEVEN M., GRIFFIN, MARGARET L., MICHAEL, JACQUELINE L.·1988·The Journal of Nervous and Mental Disease

DOI 10.1097/00005053-198812000-00004

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Abstract

The authors studied a group of 149 hospitalized cocaine abusers as a follow-up to previous research performed in 1980-82, which had revealed a high prevalence of affective disorder in cocaine abusers. The authors hypothesized that the changing epidemiology of cocaine abuse since that time may have been accompanied by changes in the characteristics of patients seeking treatment for dependence on the drug. The cocaine abusers were compared with 293 other drug abusers to see whether clinical changes over time were specific to individuals abusing cocaine. The authors found slightly more affective disorder in the cocaine abusers when compared with the other patients (26.8% vs. 20.1%), with a significantly higher rate of cyclothymic disorder (11.4% vs. 2.7%, p less than .001). Affective illness was significantly more prevalent in the first-degree relatives of the cocaine abusers when compared with the sex-matched relatives of the other patients (p less than .05). Diagnostic trends changed a great deal, however, between the original 1980-82 study sample and the follow-up 1982-86 sample. The rate of affective disorder decreased over time from 50.0% to 21.0% (p less than .01), and the rate of affective illness in the families also declined, from 31.0% to 11.5% in females (p less than .001) and from 14.3% to 2.2% in males (p less than .001). No such change occurred in the comparison group of opioid and central nervous system depressant abusers. The authors conclude that although a substantial number of cocaine abusers suffer from concurrent affective disorder, this form of premorbid psychopathology has become a less important risk factor for the development of chronic cocaine abuse as cocaine use has become more widespread.

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Background
A comparison of alcoholic and nonalcoholic drug abusers.
Weiss, R. D., Mirin, S. M., Griffin, M. L., et al. (1988) · Journal of Studies on Alcohol · doi:10.15288/jsa.1988.49.510 · Cited by 32
Self-citation
Alcohol and Cocaine
Gorelick, D. A. (1992) · Recent developments in alcoholism · doi:10.1007/978-1-4899-1648-8_2 · Cited by 28
Psychopathology in alcohol- and cocaine-dependent patients: A comparison of findings from psychological testing
Lesswing, N. J., & Dougherty, R. J. (1993) · Journal of Substance Abuse Treatment · doi:10.1016/0740-5472(93)90098-m · Cited by 28
Ethanol effects on self-administration of alfentanil, cocaine, and nomifensine in rhesus monkeys
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The formation of cocaethylene and clinical presentation of ED patients testing positive for the use of cocaine and ethanol
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Three-Month Follow-up of 28 Dual Diagnosis Inpatients
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“Indeed, epidemiological studies have found that most cocaine addicts prefer to drink ethanol with their cocaine as a means of attenuating the negative aspects of the cocaine experience, with between 50% and 90% of cocaine users co-administering ethanol during cocaine binges (Weiss et al. 1988; Grant and Harford 1990;…”
Background
ADHD and Sleep in Homicidal Men with Antisocial Personality Disorder
Lindberg, N., Tani, P., Porkka-Heiskanen, T., Appelberg, B., Rimón, R., & Virkkunen, M. (2004) · Neuropsychobiology · doi:10.1159/000077940 · Cited by 27
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Are Attention‐Deficit Hyperactivity Disorder and the Psychoactive Substance Use Disorders Really Related?
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Types of Abuse and Cocaine Use in Pregnant Women
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Chapter 44. Mood Disorders
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Self-citation
The impact of cohort substance use upon likelihood of transitioning through stages of alcohol and cannabis use and use disorder: Findings from the Australian National Survey on Mental Health and Wellbeing
Degenhardt, L. J., Glantz, M. D., Bharat, C., Peacock, A., Lago, L., Sampson, N. A., & Kessler, R. C. (2018) · Drug and Alcohol Review · doi:10.1111/dar.12679 · Cited by 19

Authors: WEISS, R. D., MIRIN, S. M., GRIFFIN, M. L., & MICHAEL, J. L.
Affiliations: Harvard University (US)
McLean Hospital (US)
ORCID: WEISS, ROGER D.
GRIFFIN, MARGARET L.
Venue: The Journal of Nervous and Mental Disease
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1988-12
Volume: 176
Issue: 12
Pages: 719-725
ISSN: 0022-3018 (ISSN-L)
DOI: 10.1097/00005053-198812000-00004
OpenAlex: W1968110132
Cited by: 175
References: 0
Citations by year: 2022: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 3
FWCI: 5.67
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Nervous and Mental Disease (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Keywords: cocaine abuse, mood disorders, cyclothymia, first-degree relatives
MeSH terms: Adult, Central Nervous System Depressants, Cocaine, Cyclothymic Disorder, Female, Humans, Male, Massachusetts, Opioid-Related Disorders, Risk Factors, Mood Disorders, Substance-Related Disorders

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Psychopathology in Cocaine Abusers: Changing Trends

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