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Low Urinary Cortisol Excretion in Patients with Posttraumatic Stress Disorder
Abstract
In the present study, we replicated and extended our previous findings of low urinary free-cortisol levels in PTSD. Cortisol was measured in 16 male patients (nine inpatients, seven outpatients) with posttraumatic stress disorder (PTSD) and in 16 nonpsychiatric control subjects. The mean cortisol level in the PTSD group was significantly lower, and the range narrower, than that observed in control subjects. Low cortisol in PTSD did not seem to be related to the presence or absence of major depressive disorder or to overall psychiatric symptomatology as assessed by the sum Brief Psychiatric Rating Scale score. In the outpatient group, there was a relationship between PTSD symptomatology and cortisol levels. The findings suggests a physiological adaptation of the hypothalamic-pituitary-adrenal axis to chronic stress.
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Citations
Cited by
Miller, G. E., Chen, E., & Zhou, E. S. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.1.25 · Cited by 2,467
Glucocorticoids and Hippocampal Atrophy in Neuropsychiatric Disorders
Sapolsky, R. M. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.10.925 · Cited by 2,016
Hippocampal atrophy in recurrent major depression
Sheline, Y. I., Wang, P. W., Gado, M. H., Csernansky, J. G., & Vannier, M. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.3908 · Cited by 1,932
The potential role of hypocortisolism in the pathophysiology of stress-related bodily disorders
Heim, C., Ehlert, U., & Hellhammer, D. H. (2000) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(99)00035-9 · Cited by 1,688
Biological studies of post-traumatic stress disorder
Pitman, R. K., Rasmusson, A. M., Koenen, K. C., Shin, L. M., Orr, S. P., Gilbertson, M. W., Milad, M. R., & Liberzon, I. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3339 · Cited by 1,529
Metadata
- Authors
- YEHUDA, R., SOUTHWICK, S. M., NUSSBAUM, G., WAHBY, V., GILLER, E. L., & MASON, J. W.
- Venue
- The Journal of Nervous and Mental Disease
- Published
- 1990-06
- Volume
- 178
- Issue
- 6
- Pages
- 366-369
- ISSN
- 0022-3018 (ISSN-L)
- OpenAlex
- W2090358044
- Cited by
- 527
- References
- 0
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- YEHUDA, R., SOUTHWICK, S. M., NUSSBAUM, G., WAHBY, V., GILLER, E. L., & MASON, J. W. (1990). Low Urinary Cortisol Excretion in Patients with Posttraumatic Stress Disorder. The Journal of Nervous and Mental Disease. https://doi.org/10.1097/00005053-199006000-00004
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