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Neuritic (Senile) Plaques and Filamentous Changes in Aged Rhesus Monkeys
Abstract
Three rhesus monkeys, whose approximate ages were 16 to 18 years old, and one 22 to 23 years old, were studied for age changes in the nervous system. The brains of all four were slightly shrunken and the meninges were fibrotic. The vessels were stiff and fibrosed, but were not atheromatous. The lateral ventricles were mildly dilated. Bodian preparations of the oldest monkey and of one of the 16− to 18-year-old monkeys revealed the presence of neuritic (senile) plaques. Serial one-micron toluidine blue-stained sections showed that some plaques were closely associated with capillaries. Electron microscopic studies revealed that the plaques were identical to those of human Alzheimer's disease except that the typical twisted tubules were absent. Outside the plaques there were scattered neurites showing degeneration of the type found in the neuritic plaques. Furthermore, two forms of rare pathological fibrillar material were found in 3 animals. One was made up of pairs of helically wound 100 Å filaments with a twist every 500 Å. The other fibrillar structures were made up of bundles of parallel filamentous elements, each about 130 Å thick, with a distinctly granular structure on longitudinal section. A list of other abnormalities includes vascular amyloidosis, lipofuscin accumulation, dark neurons undergoing phagocytosis, myelin remodeling, aggregates of large electron-dense droplets, enlarged mitochondria and mitochondria with paracrystalline inclusions, corpora amylacea, Rosenthal fibers and two types of virus-like particles.
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“The neuropathologic hallmarks of AD are neurofibrillary tangles (NFTs; including pretangles) and AβPs (including diffuse and neuritic plaques, which may also be referred to as “senile plaques” [2, 18, 19]; Fig. 1 and Table 1).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [18]
In the citing paper
“The particular toxic substance(s) within NPs still have not been completely characterized (90, 103, 278), but NPs represent a nidus in which extracellular plaque substance(s) seem to induce intracellular degenerative changes with tau pathology (18, 50, 279-281).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [18]
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The molecular pathology of Alzheimer's disease
Selkoe, D. J. (1991) · Neuron · doi:10.1016/0896-6273(91)90052-2 · Cited by 2,708
Nelson, P. T., Alafuzoff, I., Bigio, E. H., Bouras, C., Braak, H., Cairns, N. J., Castellani, R. J., Crain, B. J., Davies, P., Tredici, K. D., et al. (2012) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31825018f7 · Cited by 2,050
“diffuse and neuritic plaques, which may also be referred to as ‘‘senile plaques’’ [2, 18, 19]; Fig.”
BackgroundAlzheimer's Disease and the Amyloid-β Peptide
Murphy, M. P., & LeVine, H. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-1221 · Cited by 1,750
“While older NHPs typically show small amounts of amyloid deposition, this is quite modest compared to cases of AD [107–109].”
Abraham, C. R., Selkoe, D. J., & Potter, H. (1988) · Cell · doi:10.1016/0092-8674(88)90462-x · Cited by 900
Peters, A., & Vaughan, D. W. (1981) · Springer eBooks · doi:10.1007/978-1-4684-3929-8_1 · Cited by 900
Metadata
- Authors
- Wiśniewski, H. M., Ghetti, B., & Terry, R. D.
- Affiliations
- Albert Einstein College of Medicine (US)
- ORCID
- Ghetti, Bernardino
- Venue
- Journal of Neuropathology & Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 1973-10
- Volume
- 32
- Issue
- 4
- Pages
- 566-584
- ISSN
- 0022-3069 (ISSN-L)
- 1554-6578
- OpenAlex
- W2090601883
- Cited by
- 272
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 6 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 2 · 2013: 2 · 2012: 4
- FWCI
- 8.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuropathology & Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- neuritic plaques, amyloid plaques, Alzheimer's disease, rhesus monkeys, brain aging, fibrillar material, helical filaments, vascular amyloidosis, lipofuscin, myelin remodeling, corpora amylacea, Rosenthal fibers, virus-like particles, mitochondrial inclusions, meningeal fibrosis
- MeSH terms
- Aging, Amyloid, Animals, Haplorhini, Basal Ganglia, Brain, Brain Chemistry, Cerebral Cortex, Dementia, Disease Models, Animal, Female, Humans, Macaca, Male, Medulla Oblongata, Microscopy, Electron, Nerve Degeneration, Neurofibrils, Pons, Spinal Cord
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