The DOI matches its Crossref record; its reference list is not available.
Glial Fibrillary Acidic Protein in Radial Glia of Early Human Fetal Cerebrum: A Light and Electron Microscopic Immunoperoxidase Study
Abstract
In order to assess the nature of glial fibrillary acidic protein (GFAP) immunoreactivity in the radial glia of early human fetal cerebrum, full thickness blocks from the midconvexity of the frontoparietal region of the cerebrum of 25 human fetuses ranging from ten to 20 weeks of ovulation age were studied by light and electron microscopic (EM) immunoperoxidase methods. The presence of GFAP within radial glia was demonstrated in vibratome sections, in de-eponized 1 micron sections and in paraffin-embedded sections both at light and EM levels in suitably fixed human fetal cerebral tissue. The results indicate that the pattern of GFAP immunoreactivity observed in "routinely" processed autopsy brains, in which fixation is suboptimal, must be interpreted with care.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
GFAP is problematic as an astrocyte marker because it is not abundantly expressed in all astrocytes and is also expressed by radial glia during early development.
“Furthermore, GFAP is problematic as an astrocyte marker because it is not abundantly expressed in all astrocytes and is also expressed by radial glia during early development100.”
From Consequences of trisomy 21 for brain development in Down syndrome (2024) · cites this paper as [100]
Citations
No citation lists for this paper
No citation lists for this paper yet — checked again daily.
Cited by 93
Metadata
- Authors
- CHOI, B. H.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- CHOI, B. H.
- Venue
- Journal of Neuropathology and Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 1986-07
- Volume
- 45
- Issue
- 4
- Pages
- 408-418
- ISSN
- 0022-3069 (ISSN-L)
- OpenAlex
- W2000097640
- Cited by
- 93
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2019: 2 · 2018: 3 · 2017: 2 · 2015: 1 · 2014: 3 · 2012: 2
- FWCI
- 15.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuropathology & Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Environmental Health Sciences (ES-02928)
- Topics
- Health Sciences › Medicine › Anatomy › Classical Anatomy and Histology
- Health Sciences › Medicine › Oncology › Glioma Diagnosis and Treatment
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- glial fibrillary acidic protein, GFAP immunoreactivity, radial glia, fetal brain development, immunoperoxidase staining, fixation artifacts
- MeSH terms
- Brain, Brain Chemistry, Fetus, Glial Fibrillary Acidic Protein, Humans, Immunoenzyme Techniques, Microscopy, Microscopy, Electron
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
