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Expression of the Very Low-Density Lipoprotein Receptor (VLDL-r), an Apolipoprotein-E Receptor, in the Central Nervous System and in Alzheimerʼs Disease

Christie, Richard H., Chung, Haeyong, Rebeck, G. William, Strickland, Dudley, Hyman, Bradley T.·1996·Journal of Neuropathology and Experimental Neurology
DOI 10.1097/00005072-199604000-00012
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Abstract

The very low density lipoprotein receptor (VLDL-r) is a cell-surface molecule specialized for the internalization of multiple diverse ligands, including apolipoprotein E (apoE)-containing lipoprotein particles, via clathrin-coated pits. Its structure is similar to the low-density lipoprotein receptor (LDL-r), although the two have substantially different systemic distributions and regulatory pathways. The present work examines the distribution of VLDL-r in the central nervous system (CNS) and in relation to senile plaques in Alzheimer disease (AD). VLDL-r is present on resting and activated microglia, particularly those associated with senile plaques (SPs). VLDL-r immunoreactivity is also found in cortical neurons. Two exons of VLDL-r mRNA are differentially spliced in the mature receptor mRNA. One set of splice forms gives rise to receptors containing (or lacking) an extracellular O-linked glycosylation domain near the transmembrane portion of the molecule. The other set of splice forms appears to be brain-specific, and is responsible for the presence or absence of one of the cysteine-rich repeat regions in the binding region of the molecule. Ratios of the receptor variants generated from these splice forms do not differ substantially across different cortical areas or in AD. We hypothesize that VLDL-r might contribute to metabolism of apoE and apoE/A beta complexes in the brain. Further characterizations of apoE receptors in Alzheimer brain may help lay the groundwork for u…

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  • Activated astrocytes used in the experiments express both LDLR and LRP by immunostaining.

    “By immunostaining, these activated astrocytes express both the LDLR and LRP (data not shown), consistent with the previous observations summarized above that these are the two primary members of the LDLR family that are expressed by activated astrocytes (4 -7, 29 -31).”

    From Apolipoprotein E Receptors Mediate the Effects of β-Amyloid on Astrocyte Cultures (2000) · cites this paper as [4]

  • Neural cells express a variety of apoE receptors in the LDLR family.

    “neural cells express a variety of apoE receptors in the low density lipoprotein receptor (LDLR) family (4 -7).”

    From Apolipoprotein E Receptors Mediate the Effects of β-Amyloid on Astrocyte Cultures (2000) · cites this paper as [4]

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Metadata

Authors
Christie, R. H., Chung, H., Rebeck, G. W., Strickland, D., & Hyman, B. T.
Venue
Journal of Neuropathology and Experimental Neurology
Publisher
Oxford University Press (OUP)
Published
1996-04
Volume
55
Issue
4
Pages
491
ISSN
0022-3069
DOI
10.1097/00005072-199604000-00012
Cited by
89
References
0
Language
en

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