The DOI matches its Crossref record.
Pharmacological Drug Treatment of Alzheimer Disease: The Cholinergic Hypothesis Revisited
Abstract
Christopher J. Ladner, PhD, John M. Lee, MD, PhD; Pharmacological Drug Treatment of Alzheimer Disease: The Cholinergic Hypothesis Revisited, Journal of Neu
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In the citing paper
“reduced ACh, is associated with an insufficient synthetic action of choline O-acetyltransferase (ChAt) and a high catalytic action of acetylcholinesterase (AChE), finally, lead to the loss of cholinergic transmission at the pre-synaptic level [15].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [15]
In the citing paper
“The cholinergic hypothesis argues that the reduction of learning and mnemonic processes at the base of the disease are due to low levels of ACh in neurons”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [15]
Citations
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A review on cholinesterase inhibitors for Alzheimer’s disease
Anand, P., & Singh, B. (2013) · Archives of Pharmacal Research · doi:10.1007/s12272-013-0036-3 · Cited by 722
Scott, L. J., & Goa, K. L. (2000) · Drugs · doi:10.2165/00003495-200060050-00008 · Cited by 383
“[18-25] The cognitive deficits seen in patients with AD are thought to be primarily related to the degeneration of cholinergic neurons in the cortex and hippocampus (the cholinergic hypothesis of AD), resulting in deficits of cholinergic transmission and reduced levels of acetylcholine in these patients.[6,26-29] Howe…”
Interactions between β-amyloid and central cholinergic neurons: implications for Alzheimer’s disease
Kar, S., Slowikowski, S. P. M., Westaway, D. A., & Mount, H. T. J. (2004) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0442 · Cited by 366
“Cholinergic neurons in the brain stem and striatum are either spared or affected only in late stages of the disease.(45,47,48) Together with pharmacologic evidence of cholinergic involvement in the affected cognitive processes, these findings led to the development of a “cholinergic hypothesis” of AD.”
InfluentialBryant, J., Clegg, A. P., Nicholson, T., McIntyre, L., Broe, S. D., Gerard, K., & Waugh, N. R. (2001) · Health Technology Assessment · doi:10.3310/hta5010 · Cited by 246
Therapeutic Opportunities for Muscarinic Receptors in the Central Nervous System
Felder, C. C., Bymaster, F. P., Ward, J. S., & DeLapp, N. W. (2000) · Journal of Medicinal Chemistry · doi:10.1021/jm990607u · Cited by 235
Metadata
- Authors
- Ladner, C. J., & Lee, J. M.
- Affiliations
- Loyola University Medical Center (US)
- Corresponding author
- Lee, John M.
- ORCID
- Lee, John M.
- Venue
- Journal of Neuropathology & Experimental Neurology
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-08
- Volume
- 57
- Issue
- 8
- Pages
- 719-731
- ISSN
- 0022-3069 (ISSN-L)
- 1554-6578
- OpenAlex
- W2061570982
- Cited by
- 142
- References
- 0
- Citations by year
- 2025: 2 · 2023: 3 · 2022: 8 · 2021: 4 · 2020: 7 · 2019: 3 · 2018: 8 · 2017: 3 · 2016: 7 · 2015: 4 · 2014: 4 · 2013: 5 · 2012: 1
- FWCI
- 7.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuropathology & Experimental Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, cholinergic hypothesis, cholinesterase inhibitors, acetylcholinesterase, pharmacotherapy, cholinergic system
- MeSH terms
- Acetylcholine, Alzheimer Disease, Central Nervous System, Humans, Receptors, Muscarinic, Receptors, Nicotinic
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