Cited by 491Trauma and Emergency Care StudiesTrauma, Hemostasis, Coagulopathy, ResuscitationSepsis Diagnosis and Treatment

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Postinjury Multiple Organ Failure: A Bimodal Phenomenon

Moore, Frederick A., Sauaia, Angela, Moore, Ernest E., Haenel, James B., Burch, Jon M., Lezotte, Dennis C.·1996·The Journal of Trauma: Injury, Infection, and Critical Care

DOI 10.1097/00005373-199604000-00001

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Abstract

To better define the epidemiology of postinjury multiple organ failure (MOF), we prospectively evaluated 457 high-risk trauma patients who survived more than 48 hours. Overall, 70 (15%) developed MOF. In 27 (39%) patients, the occurrence was early, while in 43 (61%) patients the presentation was delayed. At presentation, early MOF had more cardiac dysfunction, while late MOF had greater hepatic failure. Indices of shock were more critical risk factors for early MOF, while advanced age was more important for late MOF. While early and late MOF had a similar high incidence of major infections, these appeared to be more important in precipitating late MOF. Finally, while mortality is similar, early MOF patients appear to succumb faster. In conclusion, postinjury MOF remains a significant challenge and appears to present in at least two patterns (i.e., early versus late). Better understanding of the relative roles of the dysfunctional inflammation and infections in early MOF versus late MOF may facilitate the development of new strategies for the prevention and treatment of morbid syndrome.

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Authors: Moore, F. A., Sauaia, A., Moore, E. E., Haenel, J. B., Burch, J. M., & Lezotte, D. C.
Affiliations: Denver Health Medical Center (US)
ORCID: Sauaia, Angela
Moore, Ernest E.
Venue: The Journal of Trauma: Injury, Infection, and Critical Care
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1996-04
Volume: 40
Issue: 4
Pages: 501-512
ISSN: 1079-6061
DOI: 10.1097/00005373-199604000-00001
OpenAlex: W2002764610
Cited by: 491
References: 51
Citations by year: 2026: 4 · 2025: 2 · 2024: 10 · 2023: 7 · 2022: 11 · 2021: 11 · 2020: 14 · 2019: 10 · 2018: 19 · 2017: 12 · 2016: 15 · 2015: 30 · 2014: 22 · 2013: 28 · 2012: 21
FWCI: 23.00
Type: journal article
Language: en
Open access: closed
Locations: PubMed (publishedVersion)
Funders: National Institute of General Medical Sciences (P50-GM-49222-0, P50GM049222)
Topics: Health Sciences › Medicine › Emergency Medicine › Trauma and Emergency Care Studies
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Trauma, Hemostasis, Coagulopathy, Resuscitation
Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Keywords: multiple organ failure, trauma patients, liver failure, cardiac dysfunction, shock, infection, risk factors, mortality, sepsis, systemic inflammation
MeSH terms: Adolescent, Adult, Female, Humans, Male, Middle Aged, Multiple Organ Failure, Prospective Studies, Risk Factors, Time Factors, Wounds and Injuries, Injury Severity Score

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Postinjury Multiple Organ Failure: A Bimodal Phenomenon

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