The DOI matches its Crossref record.
Corticosteroid Pharmacokinetics in the Inner Ear Fluids: An Animal Study Followed by Clinical Application
Abstract
Objective Autoimmune disease (e.g., Cogan syndrome) and other inflammatory inner ear diseases may ravage the labyrinth if not treated aggressively with antiinflammatory medication. Corticosteroids are the mainstay of treatment, yet, partly because of the existence of the blood-labyrinthine barrier, the ideal drug, dose, and route of administration are currently unknown. Study design In the present study, we established cochlear fluid pharmacokinetic profiles of hydrocortisone, methylprednisolone, and dexamethasone in the guinea pig following oral, intravenous, and topical (intratympanic) administration. High-performance liquid chromatography was used to determine the drug concentrations, and comparisons were made with simultaneous pharmacokinetic profiles from blood and cerebrospinal fluid. Results Our findings demonstrated a much higher penetration of all three drugs into the cochlear fluids following topical application as compared with systemic administration, with methylprednisolone showing the best profile. Discussion The results suggested that intratympanic administration of corticosteroids might be more efficacious while avoiding high blood levels and therefore the deleterious side effects of systemic use. Clinical application Thirty-seven patients with various inner ear disorders causing sensorineural hearing loss were subsequently treated using intratympanic corticosteroids, 20 with dexamethasone, and 17 with methlyprednisolone. Patients with immune-mediated hearing…
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“While these percentages align with previous reports, such as those from Parnes et al. who reported improvements in approximately one-third of patients following IT steroids [6]”
From Intratympanic steroid administration and predictors of recovery in sudden sensorineural hearing loss (2025) · cites this paper as [6]
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 48
- 10.1152/physrev.1988.68.4.1083 · DOI
- 10.1002/aja.1000390103 · DOI
- 10.1001/archotol.1927.00610010329001 · DOI
- 10.1177/000348946107000310 · DOI
- 10.1017/S0022215100053731 · DOI
- 10.1007/BF00453671 · DOI
- 10.1016/0378-5955(92)90071-T · DOI
- 10.1016/0306-4522(81)90142-1 · DOI
- 10.3109/00016489009125160 · DOI
- 10.1016/0378-5955(85)90131-5 · DOI
- Juhn SK, 1986, Biochemical aspects of inner ear fluids and possible implications for pharmacological treatment, Scand Audiol, 15, 7
- 10.1016/S0194-59989570170-2 · DOI
- 10.1288/00005537-198405000-00016 · DOI
- 10.1001/archotol.1980.00790360050013 · DOI
- 10.1177/019459988709700508 · DOI
- McCabe BF, 1979, Autoimmune sensorineural hearing loss, Ann Otol, 88, 585
- McCabe BF, 1989, Autoimmune inner ear disease: therapy, Am J Otol, 10, 196
- 10.3109/00016488309129581 · DOI
- 10.1159/000276348 · DOI
- 10.3109/00016489209137447 · DOI
- 10.5631/jibirin.75.2525 · DOI
- 10.1111/j.1365-2273.1992.tb01835.x · DOI
- 10.3109/00016489309126174 · DOI
- 10.1288/00005537-198406000-00006 · DOI
- Shea JJ, 1983, Autoimmune sensorineural hearing loss as an aggravating factor in Meniere's disease, Adv Otorhinolaryngol, 30, 354
- 10.1001/archotol.1990.01870060058010 · DOI
- Bernstein JM, 1987, Immunology of the Ear
- Yoo TJ, Type II collagen autoimmunity in otosclerosis and Meniere's disease, Science, 217, 1153
- 10.1177/000348948309200310 · DOI
- 10.1016/S0161-6420(84)34215-4 · DOI
- 10.1177/019459988309100105 · DOI
- 10.3109/00016489309135873 · DOI
- 10.3109/00016489309135786 · DOI
- Nedzelski JM, 1992, Chemical labyrinthectomy: local application of gentamicin for the treatment of unilateral Meniere's disease, Am J Otol, 13, 18
- Toth AA, 1995, Intratympanic gentamicin therapy for Meniere's disease: Preliminary comparison between two regimens, J Otolaryngol, 24, 340
- 10.1159/000276753 · DOI
- 10.1288/00005537-199308000-00007 · DOI
- 10.1016/0378-5955(94)90269-0 · DOI
- 10.1016/S0194-5998(96)70133-X · DOI
- 10.1288/00005537-199409000-00015 · DOI
- 10.3109/00016489509121884 · DOI
- 10.1016/S0030-6665(20)30398-4 · DOI
- 10.1016/S0030-6665(20)30362-5 · DOI · Paper page
- 10.1288/00005537-198405000-00014 · DOI · Paper page
- Schuknecht HF, 1993, Pathology of the Ear, 524
- 10.1288/00005537-199005000-00015 · DOI
- 10.3109/00016489309135813 · DOI
- Eix A, 1995, Avascular necrosis following corticosteroids, Canadian Medical Protective Association Information Letter, 10, 1
Cited by
Sorted by citations
Clinical Practice Guideline: Sudden Hearing Loss (Update)
Chandrasekhar, S. S., Tsai Do, B. S., Schwartz, S. R., Bontempo, L. J., Faucett, E. A., Finestone, S. A., Hollingsworth, D. B., Kelley, D. M., Kmucha, S. T., Moonis, G., et al. (2019) · Otolaryngology–Head and Neck Surgery · doi:10.1177/0194599819859885 · Cited by 931
Intratympanic steroid administration and predictors of recovery in sudden sensorineural hearing loss
Kennedy, D. J., Williams, E., Wolf, L., Golden, J., Lana, A., Wiefels, M., Pyle, M., Yunis, V., & Hoffer, M. (2025) · PLOS One · doi:10.1371/journal.pone.0332809 · Cited by 4
Metadata
- Authors
- Parnes, L. S., Sun, A., & Freeman, D. J.
- Affiliations
- Western University (CA)
- Venue
- The Laryngoscope
- Publisher
- Wiley
- Published
- 1999-07
- Volume
- 109
- Issue
- S91
- Pages
- 1-17
- ISSN
- 0023-852X (ISSN-L)
- 1531-4995
- OpenAlex
- W2081453354
- Cited by
- 634
- References
- 0
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 15 · 2023: 26 · 2022: 23 · 2021: 21 · 2020: 32 · 2019: 30 · 2018: 28 · 2017: 28 · 2016: 29 · 2015: 33 · 2014: 30 · 2013: 26 · 2012: 36
- FWCI
- 6.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Laryngoscope (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Health Sciences › Medicine › Otorhinolaryngology › Ear Surgery and Otitis Media
- Keywords
- intratympanic corticosteroids, methylprednisolone, dexamethasone, cortisol, inner ear disorders, sensorineural hearing loss, sudden sensorineural hearing loss, cochlear hydrops, otitis media, Cogan's syndrome, guinea pig
- MeSH terms
- Administration, Oral, Adult, Aged, Animals, Anti-Inflammatory Agents, Autoimmune Diseases, Chromatography, High Pressure Liquid, Dexamethasone, Ear, Middle, Female, Glucocorticoids, Guinea Pigs, Hearing Loss, Sensorineural, Humans, Hydrocortisone, Injections, Injections, Intravenous, Labyrinth Diseases, Labyrinthine Fluids, Male, Methylprednisolone, Middle Aged
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
