The DOI matches its Crossref record; the references it cites are not checked yet.
Anatomic Details of Intradural Channels in the Parasagittal Dura: A Possible Pathway for Flow of Cerebrospinal Fluid
Abstract
OBJECTIVE: The absorption of cerebrospinal fluid occurs primarily by means of arachnoid granulations (AG) in the superior sagittal sinus (SSS) and the lacunae laterales (LL) in the parasagittal dura. Previous descriptions of this region suggest a network of intradural channels, but finer details of extent and relationship between channels and AG were not addressed. Therefore, we undertook an anatomic study of cadaveric parasagittal dura. METHODS: The SSS and parasagittal dura of 20 formalin-fixed adult cadavers and 15 autopsy specimens from patients ranging in age from 18 weeks of gestation to 80 years were studied by use of a light microscope, a scanning electron microscope, and corrosion casting. Intradural injections into the parasagittal region were performed in two formalin-fixed and four autopsy specimens from adults by use of normal saline and corrosion casting. RESULTS: Extensive networks of intradural channels from 0.02 to 2.0 mm in diameter were noted in all of the specimens. Channels either were connected to the SSS at intervals along the side wall or drained directly into the LL, which extended up to 3 cm from midline. Channels lined with endothelium stained positive for Factor VIII, as did the endothelium of the LL and SSS. In some places, the network of channels seemed to coalesce to form LL. The underside of the dura was coarse and trabeculated where the channels were abundant, and AG were interdigitated between these trabeculae. In regions of the dura where channels were sparse or absent, the dural underside was smooth and lacked AG. Underlying cortical veins opened directly into the SSS and were unrelated to intradural channels. Intradural parasagittal injections from the epidural side accessed the SSS by way of channels using pressures between 0 and 20 cm H2O at 1.5 ml/min. CONCLUSION: These channels may represent a pathway for the flow of cerebrospinal fluid from AG to the SSS.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The region with tracer enhancement stretches laterally to a larger extent than can be anticipated from previous anatomical descriptions of intradural human arachnoid granulations.
“The region with tracer enhancement, as presented here, stretches laterally to a larger extent than what can be anticipated from the previous anatomical descriptions of intradural human arachnoid granulations14,15”
From Cerebrospinal fluid tracer efflux to parasagittal dura in humans (2020) · cites this paper as [15]
The endothelium of intradural channels was proposed to possibly be the final barrier for absorption of CSF to venous blood, but passage of CSF over this cell layer has never since been confirmed in vivo.
“The endothelium of intradural channels was proposed to possibly be the final barrier for the absorption of CSF to venous blood15, but passage of CSF over this cell layer has never since been confirmed in vivo.”
From Cerebrospinal fluid tracer efflux to parasagittal dura in humans (2020) · cites this paper as [15]
Citations
The citation lists haven’t been fetched yet
References 28 · Cited by 105
Research works printed but not linked: 1
- Picard, 1990, A la recherche du système lymphatique due névraxe, J Mal Vasc, 15, 5
Metadata
- Authors
- Fox, R. J., Walji, A. H., Mielke, B., Petruk, K. C., & Aronyk, K. E.
- Affiliations
- University of Alberta (CA)
- Venue
- Neurosurgery
- Published
- 1996-07-01
- Volume
- 39
- Issue
- 1
- Pages
- 84-91
- ISSN
- 0148-396X (ISSN-L)
- 1524-4040
- OpenAlex
- W2027937485
- Cited by
- 105
- References
- 28
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 1 · 2023: 6 · 2022: 1 · 2021: 10 · 2020: 5 · 2019: 10 · 2018: 8 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 9 · 2012: 5
- FWCI
- 0.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurosurgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
- Health Sciences › Medicine › Clinical Neurology › Neurosurgical Procedures and Complications
- Health Sciences › Medicine › Clinical Neurology › Cerebral Venous Sinus Thrombosis
- Keywords
- cerebrospinal fluid flow, arachnoid granulations, superior sagittal sinus, dural venous sinuses, dural anatomy, cerebrospinal fluid absorption
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Arachnoid, Cerebrospinal Fluid, Child, Child, Preschool, Cranial Sinuses, Dura Mater, Female, Gestational Age, Humans, Infant, Infant, Newborn, Male, Microscopy, Electron, Scanning, Middle Aged, Pregnancy, Reference Values, Corrosion Casting
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
