The DOI matches its Crossref record.
Invasive neonatal candidiasis: comparison of albicans and parapsilosis infection
Abstract
Severe infections caused by non-albicans Candida species are being increasingly reported among infants in neonatal intensive care units. To assess relative severity, mortality rates for C. albicans (CA) and C. parapsilosis (CP) infections in one neonatal intensive care unit from 1980 to 1990 were compared. Invasive candidiasis was defined as Candida recovery from a normally sterile body fluid or site with clinical signs of infection. Invasive candidiasis was diagnosed and systemic antifungal therapy initiated in 45 infants, 29 with CA and 16 with CP. No differences were found between CA and CP for birth weight, gestational age, age or weight at onset, presence of necrotizing enterocolitis, gastrointestinal or genitourinary anomalies, death (all causes), prior incidence or duration of antibiotics, parenteral nutrition, steroids or endotracheal intubation. Candida infection as the cause of death was more frequent with CA than CP (7 of 29 vs. 0 of 16; P = 0.034). Infants with CA were more likely to have antecedent thrush (P = 0.007) and perineal Candida dermatitis (P less than 0.02); those with CP were more likely to have vascular catheters at the time of positive culture (P less than 0.02). Though both pathogens occur in similar neonatal intensive care unit infants and can cause severe disease, CA appears more likely to result in death than CP.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, neonates born prematurely or infants with low birth weight and prolonged rupture of cutaneous membranes, the cutaneous process may become invasive and produce acute disseminated candidiasis [165].”
From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [165]
Citations
Cited by
Sorted by citations
Guidelines for Treatment of Candidiasis
Pappas, P. G., Rex, J. H., Sobel, J. D., Filler, S. G., Dismukes, W. E., Walsh, T. J., & Edwards, J. E. (2004) · Clinical Infectious Diseases · doi:10.1086/380796 · Cited by 1,440
“However, neonates born prematurely or infants with low birth weight and prolonged rupture of cutaneous membranes, the cutaneous process may become invasive and produce acute disseminated candidiasis [165].”
BackgroundPractice Guidelines for the Treatment of Candidiasis
Rex, J. H., Walsh, T. J., Sobel, J. D., Filler, S. G., Pappas, P. G., Dismukes, W. E., & Edwards, J. E. (2000) · Clinical Infectious Diseases · doi:10.1086/313749 · Cited by 927
“However, in premature or low–birth weight neonates or infants with prolonged rupture of membranes, the cutaneous process may become invasive and thus produce acute disseminated candidiasis [73].”
BackgroundClinical Microbiology of Bacterial and Fungal Sepsis in Very-Low-Birth-Weight Infants
Kaufman, D. A., & Fairchild, K. D. (2004) · Clinical Microbiology Reviews · doi:10.1128/cmr.17.3.638-680.2004 · Cited by 437
“Mortality is higher in ELBW infants who develop fungal sepsis and has been reported at between 37 and 40% (149, 246), while fungal sepsis occurring after 4 weeks of life has been associated with lower mortality (133).”
BackgroundRisk factors for Candida species colonization of neonatal intensive care unit patients
Saiman, L. M., Ludington, E. A., Dawson, J. D., PATTERSON, J. E., Rangel-Frausto, S., Wiblin, R. T., Blumberg, H. M., Pfaller, M. A., Rinaldi, M. G., EDWARDS, J. E., et al. (2001) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-200112000-00005 · Cited by 346
Shin, J. H., Kee, S., Shin, M., Kim, S. H., Shin, D. H., Lee, S. K., Suh, S., & Ryang, D. W. (2002) · Journal of Clinical Microbiology · doi:10.1128/jcm.40.4.1244-1248.2002 · Cited by 335
“parapsilosis candidemia, which clears more easily than bloodstream infections by other Candida species (8, 12, 15, 21).”
Background
Metadata
- Authors
- FAIX, R. G.
- Affiliations
- Women's Hospital (US)
- Corresponding author
- FAIX, ROGER G.
- Venue
- The Pediatric Infectious Disease Journal
- Published
- 1992-02
- Volume
- 11
- Issue
- 2
- Pages
- 88-92
- ISSN
- 0891-3668 (ISSN-L)
- OpenAlex
- W2067549921
- Cited by
- 122
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2021: 1 · 2018: 1 · 2016: 5 · 2014: 2 · 2013: 8 · 2012: 4
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Pediatric Infectious Disease Journal (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Keywords
- invasive candidiasis, neonatal candidiasis, Candida albicans, Candida parapsilosis, non-albicans Candida, mortality, antifungal therapy, vascular catheters, necrotizing enterocolitis, neonatal intensive care unit infants
- MeSH terms
- Candida, Candida albicans, Candidiasis, Female, Humans, Infant, Newborn, Intensive Care Units, Neonatal, Male
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
