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Cited by 153Bacterial Infections and VaccinesPneumonia and Respiratory InfectionsMicrobial infections and disease research

The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.

Epidemiology of Haemophilus influenzae type b disease and impact of Haemophilus influenzae type b conjugate vaccines in the United States and Canada.

WENGER, JAY D.·1998·The Pediatric Infectious Disease Journal
DOI 10.1097/00006454-199809001-00008
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Abstract

Haemophilus influenzae type b (Hib) was the major cause of invasive bacterial disease in the United States and Canada before the introduction of Hib conjugate vaccines. Between 10000 and 20000 cases of Hib meningitis and other serious diseases occurred each year, leading to death in at least 3% of all patients and long term neurologic problems in up to 25% of survivors of meningitis. Introduction of Hib conjugate vaccines in Canada and the United States, first in children 18 months and older and later as a routine infant immunization, dramatically decreased the incidence of disease. By 1995 Hib disease levels had declined by more than 95% below preimmunization levels. The remarkably rapid reduction in disease incidence was partly because of the ability of the vaccine to reduce nasopharyngeal carriage of the organism, leading, when given widely, to reduced rates of exposure and infection even in those not immunized. Complete elimination of Hib disease in North America, however, will require achievement of relatively high coverage rates, especially in hard to reach populations where much of the remaining disease is occurring.

Overview

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Crossref · 10.1097/00006454-199809001-00008

Cites

20 of 20 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 19 references

Research works printed but not linked: 5

  1. Ward, 1986, J Infect Dis, 108, 887
  2. 1996, MMWR, 45, 901
  3. Schoendorf, 1994, Pediatrics, 93, 663
  4. 1996, Can Comm Dis Rep, 22S, 63
  5. 1996, Can Med Assoc J, 154, 1041

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Metadata

Authors
WENGER, J. D.
Affiliations
World Health Organization (CH)
Corresponding author
WENGER, JAY D.
Venue
The Pediatric Infectious Disease Journal
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1998-09
Volume
17
Issue
Supplement
Pages
S132-S136
ISSN
0891-3668 (ISSN-L)
DOI
10.1097/00006454-199809001-00008
OpenAlex
W2313044730
Cited by
153
References
19
Citations by year
2025: 6 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 5 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 3 · 2014: 7 · 2013: 9 · 2012: 8
FWCI
4.81
Type
journal article
Language
en
Open access
closed
Locations
  • The Pediatric Infectious Disease Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
  • Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
  • Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
Keywords
Haemophilus influenzae type b, Hib conjugate vaccine, invasive bacterial infection, Hib meningitis, nasopharyngeal carriage, vaccine impact, disease incidence decline, herd protection, vaccination coverage, neurological sequelae, United States, Canada
MeSH terms
Canada, Child, Preschool, Haemophilus Infections, Humans, Infant, United States, Vaccination, Haemophilus Vaccines, Vaccines, Conjugate, Haemophilus influenzae type b

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