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Cited by 110Asthma and respiratory diseasesVaccine Coverage and HesitancyPharmacovigilance and Adverse Drug Reactions

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Childhood vaccinations and risk of asthma

DESTEFANO, FRANK, GU, DAVID, KRAMARZ, PIOTR, TRUMAN, BENEDICT I., IADEMARCO, MICHAEL F., MULLOOLY, JOHN P., JACKSON, LISA A., DAVIS, ROBERT L., BLACK, STEVEN B., SHINEFIELD, HENRY R., MARCY, S. MICHAEL, WARD, JOEL I., CHEN, ROBERT T.·2002·The Pediatric Infectious Disease Journal
DOI 10.1097/00006454-200206000-00004
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Abstract

BACKGROUND: A few previous studies have suggested that childhood vaccines, particularly whole cell pertussis vaccine, may increase the risk of asthma. We evaluated the suggested association between childhood vaccinations and risk of asthma. METHODS: Cohort study involving 167,240 children who were enrolled in 4 large health maintenance organizations during 1991 to 1997, with follow-up from birth until at least 18 months to a maximum of 6 years of age. Vaccinations were ascertained through computerized immunization tracking systems, and onset of asthma was identified through computerized data on medical care encounters and medication dispensings. RESULTS: In the study 18,407 children (11.0%) developed asthma, with a median age at onset of 11 months. The relative risks (95% confidence intervals) of asthma were: 0.92 (0.83 to 1.02) for diphtheria, tetanus and whole cell pertussis vaccine; 1.09 (0.9 to 1.23) for oral polio vaccine; 0.97 (0.91 to 1.04) for measles, mumps and rubella (MMR) vaccine; 1.18 (1.02 to 1.36) for Haemophilus influenzae type b (Hib); and 1.20 (1.13 to 1.27) for hepatitis B vaccine. The Hib result was not consistent across health maintenance organizations. In a subanalysis restricted to children who had at least 2 medical care encounters during their first year, the relative risks decreased to 1.07 (0.71 to 1.60) for Hib and 1.09 (0.88 to 1.34) for hepatitis B vaccine. CONCLUSION: There is no association between diphtheria, tetanus and whole cell pertussis vaccine, oral polio vaccine or measles, mumps and rubella vaccine and the risk of asthma. The weak associations for Hib and hepatitis B vaccines seem to be at least partially accounted for by health care utilization or information bias.

Overview

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Crossref · 10.1097/00006454-200206000-00004

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Citations

Cites

Research works printed but not linked: 6

  1. Odent, 1994, JAMA, 592-, 3
  2. Mu, 1994, Immunology, 83, 639
  3. Johnston, 1986, Am Rev Respir Dis, 143, 270
  4. Wjst, 1994, Ann Allergy, 73, 450
  5. Ryan, 1997, Dev Biol Stand, 89, 297
  6. Platts-Mills, 1997, CIBA Found Symp, 206, 173

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Metadata

Authors
DESTEFANO, F., GU, D., KRAMARZ, P., TRUMAN, B. I., IADEMARCO, M. F., MULLOOLY, J. P., JACKSON, L. A., DAVIS, R. L., BLACK, S. B., SHINEFIELD, H. R., MARCY, S. M., WARD, J. I., & CHEN, R. T.
Affiliations
Centers for Disease Control and Prevention (US)
ORCID
Venue
The Pediatric Infectious Disease Journal
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2002-06
Volume
21
Issue
6
Pages
498-504
ISSN
0891-3668 (ISSN-L)
DOI
10.1097/00006454-200206000-00004
OpenAlex
W2090329806
Cited by
109
References
40
Citations by year
2026: 1 · 2025: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 2
FWCI
6.59
Type
journal article
Language
en
Open access
closed
Locations
  • The Pediatric Infectious Disease Journal (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
  • Social Sciences › Health › Vaccine Coverage and Hesitancy
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
Keywords
childhood immunization, asthma risk, whole-cell pertussis vaccine, DTP vaccine, oral polio vaccine, MMR vaccine, Haemophilus influenzae type b vaccine, hepatitis B vaccine, vaccine safety, health maintenance organizations
MeSH terms
Asthma, Child, Female, Humans, Infant, Infant, Newborn, Male, Poliovirus Vaccine, Oral, Risk Factors, Viral Vaccines, Cohort Studies, Diphtheria-Tetanus-Pertussis Vaccine, Incidence, Measles-Mumps-Rubella Vaccine

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