Ceftriaxone for Treatment of Primary Syphilis in Men: A Preliminary Study
Abstract
Eighteen male patients with primary syphilis were randomly assigned to one of the following treatment schedules: ceftriaxone (3 g in a single intramuscular [im] injection), ceftriaxone (2 g im daily for two days), ceftriaxone (2 g im daily for five days), and benzathine penicillin (2.4 X 10(6) units in a single im injection). The single 3-g dose of ceftriaxone cured three men, one had a sustained response, and one failed to be cured. Of the patients given 2 g of ceftriaxone im daily for two days, three were cured and two had a sustained response. All three men treated with 2 g of ceftriaxone daily for five days had a sustained response. In the group given penicillin, three men were cured, one had a sustained response, and one was lost to follow-up.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Several different ceftriaxone regimens have been shown to be effective for the treatment of early syphilis.
“Several different ceftriaxone regimens have been shown to be effective for the treatment of early syphilis.104–113”
From BASHH UK guidelines for the management of syphilis 2024 (2024) · cites this paper as [109]
Cited by
Sorted by citations
Dowell, M. E., Ross, P. G., Musher, D. M., Cate, T. R., & Baughn, R. E. (1992) · The American Journal of Medicine · doi:10.1016/0002-9343(92)90574-u · Cited by 133 · see citing works
BASHH UK guidelines for the management of syphilis 2024
Kingston, M., Apea, V., Evans, C., Fifer, H., Foster, K., Patrick, P., Grant, A., Manns, V., Ramsden, S., Sinka, K., et al. (2024) · International Journal of STD & AIDS · doi:10.1177/09564624241280406 · Cited by 51 · see citing works
- Authors
- MOORTHY, T. T., LEE, C.-T., LIM, K.-B., & TAN, T.
- Venue
- Sexually Transmitted Diseases
- Published
- 1987-04
- Volume
- 14
- Issue
- 2
- Pages
- 116-118
- ISSN
- 0148-5717 (ISSN-L)
- OpenAlex
- W1990798314
- Cited by
- 52
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2022: 3 · 2021: 1 · 2020: 1 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 1
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Sexually Transmitted Diseases (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Syphilis Diagnosis and Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Historical Medical Research and Treatments
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- ceftriaxone, primary syphilis, benzathine penicillin, antibiotic dosing schedule, men, syphilis treatment
- MeSH terms
- Adolescent, Adult, Ceftriaxone, Drug Administration Schedule, Humans, Male, Middle Aged, Penicillin G Benzathine, Prospective Studies, Random Allocation, Syphilis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
