The DOI matches its Crossref record; 104 of the 104 references it cites were found in a registry or an index.
Matrix Metalloproteinases: The Clue to Intervertebral Disc Degeneration?
Abstract
STUDY DESIGN: A review of the current literature on the role of matrix metalloproteinases in intervertebral disc degeneration. OBJECTIVE: To detail the characteristics of matrix metalloproteinases (classification, structure, substrate specificity and regulation) and to report previous studies of intervertebral discs. SUMMARY OF BACKGROUND DATA: Degeneration of the intervertebral disc, a probable prerequisite to disc herniation, is a complex phenomenon, and its physiopathologic course remains unclear. Matrix metalloproteinases probably play an important role but have received sparse attention in the literature. METHODS: A systematic review of studies reporting a role of matrix metalloproteinases in intervertebral disc degeneration. RESULTS: In several studies, investigators have reported the presence of proteolytic enzymes from disc culture systems and disc tissue extracts in degenerated human intervertebral discs, especially collagenase-1 (MMP-1) and stromelysin-1 (MMP-3). The matrix metalloproteinases are regulated by specific inhibitors (tissue inhibitors of metalloproteinases, or TIMPS), cytokines (interleukin-1), and growth factors. CONCLUSIONS: This field of application is of particular interest because conventional treatments are disappointing in chronic low back pain. Clinical trials with specific inhibitors of metalloproteinases are beginning in osteoarthritis.
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Cites
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Metalloproteinases and their inhibitors in matrix remodeling
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Cited by
Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc
Le Maitre, C. L., Freemont, A. J., & Hoyland, J. A. (2004) · The Journal of Pathology · doi:10.1002/path.1608 · Cited by 443
Self-citationThe pathophysiology of disc degeneration: A CRITICAL REVIEW
Hadjipavlou, A. G., Tzermiadianos, M. N., Bogduk, N., & Zindrick, M. R. (2008) · The Journal of Bone and Joint Surgery. British volume · doi:10.1302/0301-620x.90b10.20910 · Cited by 365
Roughley, P., Hoemann, C., DesRosiers, E., Mwale, F., Antoniou, J., & Alini, M. (2006) · Biomaterials · doi:10.1016/j.biomaterials.2005.06.037 · Cited by 260
Matrix metalloproteinase-10: a novel biomarker for idiopathic pulmonary fibrosis
Sokai, A., Handa, T., Tanizawa, K., Oga, T., Uno, K., Tsuruyama, T., Kubo, T., Ikezoe, K., Nakatsuka, Y., Tanimura, K., et al. (2015) · Respiratory Research · doi:10.1186/s12931-015-0280-9 · Cited by 64
Metadata
- Authors
- Goupille, P., Jayson, M. I. V., Valat, J.-P., & Freemont, A. J.
- Venue
- Spine
- Published
- 1998-07
- Volume
- 23
- Issue
- 14
- Pages
- 1612-1626
- ISSN
- 0362-2436 (ISSN-L)
- OpenAlex
- W2326211238
- Cited by
- 287
- References
- 104
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Goupille, P., Jayson, M. I. V., Valat, J.-P., & Freemont, A. J. (1998). Matrix Metalloproteinases: The Clue to Intervertebral Disc Degeneration? Spine. https://doi.org/10.1097/00007632-199807150-00021
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