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THE PROGNOSTIC VALUE OF THE EOSINOPHIL IN ACUTE RENAL ALLOGRAFT REJECTION
Abstract
A case report of marked peripheral blood eosinophilia and eosinophilic infiltration of a rejected renal allograft in a transplant recipient stimulated our review of the clinical course of 132 consecutive renal transplant recipients. A total of 187 acute rejections occurred in 112 patients. Diagnosis was made by renal biopsy in 124 cases. The percentage of eosinophils in the leukocyte differential of patients with irreversible rejection was 5.2 +/- 5.7 (mean +/- SD) versus that seen in patients with reversible rejection, 2.9 +/- 3.5 (P less than .05). The difference in the total eosinophil counts in each group was not statistically significant. Patients with peripheral blood eosinophil percentages greater than or equal to 4% had a 37.9% irreversible rejection rate, whereas those who had less than 4%, had a 22.4% loss rate (P less than .01). Six of seven patients with greater than or equal to 2% eosinophils in the inflammatory infiltrate of their renal allograft lost their kidney, whereas grafts with less than 2% eosinophils had a 36.8% loss rate (P less than .02). We conclude that the increased presence of eosinophils in the peripheral blood and/or renal allograft biopsy specimen is an adverse prognostic factor for acute rejection outcome.
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“eosinophil infiltration is a prominent marker of allograft rejection and predicts a poor prognosis25,26.”
From Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal transplantation (2019) · cites this paper as [25]
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“…需要更多的研究进行证实。对于嗜酸性粒细胞的变 化，有研究 [23] 揭示嗜酸性粒细胞数量 0.3×10 9 /L 是肾 移植术后 3 个月内发生排斥反应的独立风险因素，这 种风险是嗜酸性粒细胞数量 0.3×10 9 /L 受者的 3 倍。 另有研究 [24] 认为嗜酸性粒细胞的增加预示着急性排斥 反应的预后较差，嗜酸性粒细胞比例 4% 的急性排 斥病例中 37.9% 的病例为不可逆性排斥反应。本研究 但有研究 [25-26] 提示嗜碱性粒细胞的减少与狼疮肾炎的 发生存在关联。这提示嗜碱性粒细胞的减少可能与 肾损伤存在关联。…”
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Metadata
- Authors
- WEIR, M. R., HALL-CRAGGS, M., SHEN, S. Y., POSNER, J. N., ALONGI, S. V., DAGHER, F. J., & SADLER, J. H.
- Affiliations
- University of Maryland Medical Center (US)
- ORCID
- WEIR, MATTHEW R.
- Venue
- Transplantation
- Published
- 1986-06
- Volume
- 41
- Issue
- 6
- Pages
- 709-712
- ISSN
- 0041-1337 (ISSN-L)
- OpenAlex
- W2069617592
- Cited by
- 69
- References
- 0
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 1 · 2021: 3 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Transplantation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Transplantation › Organ and Tissue Transplantation Research
- Keywords
- eosinophils, acute renal allograft rejection, peripheral eosinophilia, eosinophil infiltration, graft loss, prognostic factors, kidney transplant recipients
- MeSH terms
- Acute Disease, Eosinophilia, Graft Rejection, Humans, Leukocyte Count, Prognosis, Retrospective Studies, Transplantation, Homologous, Kidney Transplantation
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