Cited by 405Cannabis and Cannabinoid ResearchNeurotransmitter Receptor Influence on BehaviorNicotinic Acetylcholine Receptors Study

The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.

SR141716, a central cannabinoid (CB1) receptor antagonist, blocks the motivational and dopamine-releasing effects of nicotine in rats

Cohen, C., Perrault, G., Voltz, C., Steinberg, R., Soubrié, P.·2002·Behavioural Pharmacology

DOI 10.1097/00008877-200209000-00018

Open this paper in CoChat — free account

Abstract

The central CB(1) cannabinoid receptor has recently been implicated in brain reward function. In the present study we evaluated first the effects of the selective CB(1) receptor antagonist, SR141716, on the motivational effects of nicotine in the rat. Administration of SR141716 (0.3 and 1 mg/kg) decreased nicotine self-administration (0.03 mg/kg/injection). SR141716 (0.3-3 mg/kg) neither substituted for nicotine nor antagonized the nicotine cue in a nicotine discrimination procedure, but dose-dependently (0.01-1 mg/kg) antagonized the substitution of nicotine for D-amphetamine, in rats trained to discriminate D-amphetamine. Secondly, using brain microdialysis, SR141716 (1-3 mg/kg) blocked nicotine-induced dopamine release in the shell of the nucleus accumbens (NAc) and the bed nucleus of the stria terminalis. To investigate whether SR141716 would block the dopamine-releasing effects of another drug of abuse, we extended the neurochemical study to the effect of ethanol, consumption of which in rodents is reduced by SR141716. Dopamine release induced by ethanol in the NAc was also reduced by SR141716 (3 mg/kg). These results suggest that activation of the endogenous cannabinoid system may participate in the motivational and dopamine-releasing effects of nicotine and ethanol. Thus, SR141716 may be effective in reduction of alcohol consumption, as previously suggested, and as an aid for smoking cessation.

Integrity signals

Registry

Crossref · 10.1097/00008877-200209000-00018

Cites

78 of 78 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Structure of a cannabinoid receptor and functional expression of the cloned cDNA
Matsuda, L. A., Lolait, S. J., Brownstein, M. J., Young, A. C., & Bonner, T. I. (1990) · Nature · doi:10.1038/346561a0 · Cited by 5,011
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB 1 Receptor Knockout Mice
Ledent, C. A., Valverde, O., Cossu, G., Petitet, F., Aubert, J.-F., Beslot, F., Böhme, G. A., Impérato, A., Pedrazzini, T., Roques, B. P., et al. (1999) · Science · doi:10.1126/science.283.5400.401 · Cited by 3,628
Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish
Gaoni, Y., & Mechoulam, R. (1964) · Journal of the American Chemical Society · doi:10.1021/ja01062a046 · Cited by 2,389
SR141716A, a potent and selective antagonist of the brain cannabinoid receptor
Rinaldi, M. L., Barth, F., Héaulme, M., Shire, D. J., Calandra, B., Congy, C., Martinez, S., Maruani, J., Neliat, G., Caput, D., et al. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00773-x · Cited by 1,762
Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system
Tsou, K., Brown, S., Sañudo-Peña, M. C., Mackie, K., & Walker, J. M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00436-3 · Cited by 1,586
The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking
Ikemoto, S., & Panksepp, J. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00023-5 · Cited by 1,450
Cannabinoid and Heroin Activation of Mesolimbic Dopamine Transmission by a Common µ 1 Opioid Receptor Mechanism
Tanda, G., Pontieri, F. E., & Chiara, G. D. (1997) · Science · doi:10.1126/science.276.5321.2048 · Cited by 1,085
Effects of nicotine on the nucleus accumbens and similarity to those of addictive drugs.
Pontieri, F. E., Tanda, G., Orzi, F., & Chiara, G. D. (1996) · Nature · doi:10.1038/382255a0 · Cited by 1,073
The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine
Corrigall, W. A., Franklin, K. B. J., Coen, K. M., & Clarke, P. B. S. (1992) · Psychopharmacology · doi:10.1007/bf02245149 · Cited by 829

Show all 77 references

Research works printed but not linked: 3

Cohen, 1999b, NIDA Research Monograph US Department of Health Human Services, 180, 197
deFonseca, 1999, Acta Pharmacol Sin, 20, 1109
De Vries, 2001, Nature, 7, 1511

Sorted by citations

Items 301–400 of 405

6 Recent Progress in Cannabinoid Research
Adam, J., Cowley, P. M., Kiyoi, T., Morrison, A. J., & Mort, C. (2006) · Progress in medicinal chemistry · doi:10.1016/s0079-6468(05)44406-9 · Cited by 7
Self-administering cannabinoids
Glickfeld, L. L., & Scanziani, M. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.05.001 · Cited by 7
The Endocannabinoid System
Basavarajappa, B. S., Yalamanchili, R., Cooper, T. B., & Hungund, B. L. (2008) · Springer eBooks · doi:10.1007/978-0-387-30382-6_14 · Cited by 7
Bases genéticas del hábito tabáquico
Barrueco, M., Alonso, A., & González‐Sarmiento, R. (2005) · Medicina Clínica · doi:10.1157/13071764 · Cited by 6
Partial nicotinic acetylcholine (α4β2) agonists as promising new medications for smoking cessation
Budhiraja, S., & Singh, J. (2008) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.44150 · Cited by 6
Suppressing effect of the novel positive allosteric modulator of the GABAB receptor, COR659, on locomotor hyperactivity induced by different drugs of abuse
Lobina, C., Maccioni, P., Lorrai, I., Zaru, A., Collu, M., Carai, M. A. M., Brizzi, A., Mugnaini, C., Gessa, G. L., Corelli, F., et al. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.113045 · Cited by 6
The influence of stress and social defeat on neurobiological reinforcement mechanisms across reward to withdrawal in nicotine addiction
Shankar, K., Bonnet-Zahedi, S., & George, O. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06852-5 · Cited by 6
The CB1 receptor: linking impulsivity and substance use disorder
Belmont, O. A., Becerril-Meléndez, L. A., & Méndez‐Díaz, M. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1621242 · Cited by 6
The Role of Endocannabinoid System in Neuroprotection: Molecular Targets and Therapeutic Opportunities
Thapa, S., & Singh, S. K. (2023) · Integrative Medicine Reports · doi:10.1089/imr.2022.0091 · Cited by 4
An appraisal of smoking cessation aids
Mundey, K. (2009) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e328321862e · Cited by 5
Evaluation of the abuse potential of AM281, a new synthetic cannabinoid CB1 receptor antagonist
Botanas, C. J., de la Peña, J. B., Peña, I. J. D., Tampus, R., Kim, H. J., Yoon, S. S., Seo, J., Jeong, E. J., & Cheong, J. H. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.10.004 · Cited by 5
Nicotine-induced enhancement of a sensory reinforcer in adult rats: antagonist pretreatment effects
Satanove, D. J., Rahman, S., Chan, T. M. V., Ren, S. E., & Clarke, P. B. S. (2020) · Psychopharmacology · doi:10.1007/s00213-020-05696-5 · Cited by 5
Acute and chronic effects by nicotine on striatal neurotransmission and synaptic plasticity in the female rat brain
Lucente, E., Söderpalm, B., Ericson, M., & Adermark, L. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1104648 · Cited by 5
A longitudinal analysis of the effects of a DRD4 polymorphism on marijuana use
Vaske, J. C., Boisvert, D. L., WRIGHT, J. P., & Beaver, K. M. (2013) · Psychiatry Research · doi:10.1016/j.psychres.2013.04.022 · Cited by 7
Neuroanatomical basis for therapeutic applications of cannabinoid receptor 1 antagonists
Thomas, B. F. (2009) · Drug Development Research · doi:10.1002/ddr.20333 · Cited by 5
Cannabinoid-Nicotine Interactions
Auber, A., Justinová, Z., Scherma, M., Goldberg, S. R., & Panlilio, L. V. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2294-9_13 · Cited by 4
Effects of dietary conjugated linoleic acid in broiler breeders and egg storage time on the fatty acid profile, lipid oxidation and internal egg quality
Silvério, P. S., de Lima, C. B., Silva, F. L. D., Mendonça, M. A., Tanure, C. B., Stringhini, J. H., & Racanicci, A. M. C. (2023) · Animal Production Science · doi:10.1071/an22241 · Cited by 4
Cannabinoids and Endocannabinoids
Jung, K., & Piomelli, D. (2015) · Springer eBooks · doi:10.1007/978-1-4614-6434-1_136-1 · Cited by 4
Endocannabinoid Signaling in Reward and Addiction: From Homeostasis to Pathology
Laredo, S. A., Marrs, W., & Parsons, L. H. (2017) · Springer eBooks · doi:10.1007/978-3-319-57371-7_10 · Cited by 5
The Endocannabinoid System and the Therapeutic Potential of Cannabinoids
Martin, B. R. (2007) · Humana Press eBooks · doi:10.1007/978-1-59259-947-9_6 · Cited by 4
The Role of the Endocannabinoid System in Addiction
Trigo, J. M., & Foll, B. L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809666-6.00006-x · Cited by 4
Cannabinoids and Endocannabinoids
Jung, K., & Piomelli, D. (2016) · Springer eBooks · doi:10.1007/978-1-4939-3474-4_136 · Cited by 4
Cannabinoids in appetite and obesity
Barth, F., & Rinaldi, M. L. (2005) · Birkhäuser-Verlag eBooks · doi:10.1007/3-7643-7358-x_13 · Cited by 4
The cannabinoid system and impulsive behavior
Wiskerke, J., & Pattij, T. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-417041-4.00014-x · Cited by 3
Cannabinoids: Drug or Medication?
Giron, L., & Befort, K. (2016) · InTech eBooks · doi:10.5772/63172 · Cited by 4
Intra-accumbal blockade of endocannabinoid CB1 receptors impairs learning but not retention of conditioned relief
Bergado-Acosta, J. R., Schneider, M., & Fendt, M. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.06.001 · Cited by 3
Interaction of alcohol with drugs of abuse and medicines
Singh, A. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819680-9.00002-0 · Cited by 3
Pharmakologische Strategien zur Unterstützung einer Raucherentwöhnung
Vasić, N., Wolf, R. C., Wolf, N. D., Connemann, B. J., & Sosic-Vasic, Z. (2011) · Der Nervenarzt · doi:10.1007/s00115-010-3203-5 · Cited by 3
Endocannabinoids and Dopamine-Related Functions in the CNS
de Miguel, R., Ramos, J. A., Cebeira, M., Hernández, M., & Fernández‐Ruíz, J. (2005) · CRC Press eBooks · doi:10.1201/9781420023640.ch11 · Cited by 3
Measurement of affective state during chronic nicotine treatment and withdrawal by affective taste reactivity in mice: The role of endocannabinoids
Wing, V. C., Cagniard, B., Murphy, N. P., & Shoaib, M. C. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.06.017 · Cited by 2
CB1 receptor inverse agonist pharmacotherapy for metabolic disorders
Fong, T. M., Addy, C., Erondu, N., & Heymsfield, S. B. (2009) · Drug Development Research · doi:10.1002/ddr.20335 · Cited by 2
Diagnosis of abuse and addiction
Lesch, O., Walter, H., Wetschka, C., Hesselbrock, M. N., & HESSELBROCK, V. M. (2011) · Springer eBooks · doi:10.1007/978-3-7091-0146-9_5 · Cited by 2
Peroxisome Proliferator-Activated Nuclear Receptors and Drug Addiction
Mascia, P., Tanda, G., Yaşar, S., Heishman, S. J., & Goldberg, S. R. (2012) · The Receptors · doi:10.1007/978-1-4614-4669-9_11 · Cited by 2
Critical Role of Cannabinoid CB1 Receptors in Nicotine Reward and Addiction
Rezayof, A., & Hashemizadeh, S. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800213-1.00015-8 · Cited by 2
Endocannabinoid-Dependent Synaptic Plasticity in the Striatum
Atwood, B. K., & Lovinger, D. M. (2017) · Springer eBooks · doi:10.1007/978-3-319-57371-7_5 · Cited by 2
Die medikamentöse Therapie von Missbrauch und Abhängigkeiten (Tabak, Alkohol und illegale Drogen)
Lesch, O., Platz, W. E., Soyka, M., & Walter, H. (2010) · Springer eBooks · doi:10.1007/978-3-211-85473-0_18 · Cited by 2
¿Por qué y cómo tener en cuenta al cannabis en nuestros pacientes fumadores?
Olano-Espinosa, E., Polo, A. L., Grifell, M., Ogué, M. C. P., Folgar, M. I., & Arnedillo, J. J. M. (2018) · Atención Primaria · doi:10.1016/j.aprim.2018.05.014 · Cited by 2
Quels futurs traitements pour la dépendance au tabac et au cannabis ?
Foll, B. L., Justinová, Z., Tanda, G., & Goldberg, S. R. (2008) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/s0001-4079(19)32867-5 · Cited by 2
Behavioral Effects of Endocannabinoids
Fride, E., Thiébot, M.-H., Onaivi, E. S., & Chaperon, F. (2005) · CRC Press eBooks · doi:10.1201/9781420023640.ch13 · Cited by 2
Cannabinoid Antagonists
Anthenelli, R. M. (2006) · CRC Press eBooks · doi:10.1201/9781420005431.ch13 · Cited by 2
Endocannabinoid-Dopamine Interactions Shape Ethologically Relevant Behavior through Computation of Conditioned Stimuli
Oleson, E. B., & Cheer, J. F. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2294-9_8 · Cited by 1
Nicotine addiction and its Pharmacological effects: A Review
Sunil, K., Nain, P., & Singh, J. (2011) · Cited by 1
The Cannabinoid System in Nicotine Dependence and Withdrawal
McIlwain, M., Minassian, A., & Perry, W. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802574-1.00009-0 · Cited by 1
Nicotine Reward and Abstinence: Role of the CB1 Receptors
Tannous, S., & Caillé, S. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813035-3.00037-x · Cited by 1
Cannabinoids and Endocannabinoids
Jung, K., & Piomelli, D. (2022) · Springer eBooks · doi:10.1007/978-1-4614-6434-1_136-2 · Cited by 1
Indirect and direct cannabinoid agonists differentially affect mesolimbic dopamine release and related behaviors.
Honeywell, K. M., Freels, T. G., McWain, M. A., Chaffin, A. S., Nolen, H. G., Sable, H. J. K., & Lester, D. B. (2024) · Behavioral Neuroscience · doi:10.1037/bne0000582 · Cited by 1
Dopamine D3 Receptor Antagonist SB-277011A Influences Cell Firing in the Rat Ventral Tegmental Area, Parallel Role with the Cannabinoid System in Addiction and Neuropsychiatry Disorders?
Formenti, F., Sonntag, V., Congestrì, F., & Crespi, F. (2009) · The Open Neuropsychopharmacology Journal · doi:10.2174/1876523800902020086 · Cited by 1
Nicotine Self-Administration
Sorge, R. E., & Clarke, P. B. S. (2010) · Neuromethods · doi:10.1007/978-1-60761-934-5_4 · Cited by 1
Therapeutic Strategies in Alcohol and Tobacco Addiction
Lesch, O., Walter, H., Wetschka, C., Hesselbrock, M. N., HESSELBROCK, V. M., & Pombo›, S. (2020) · Springer eBooks · doi:10.1007/978-3-030-41941-7_9 · Cited by 1
Exploration of potential role of Rho GTPase in nicotine dependence-induced withdrawal syndrome in mice
Rather, I., Behl, T., Sehgal, A., Singh, S., Sharma, N., Sharma, A., Bhatia, S., Al‐Harrasi, A., Khan, N., Khan, H. Z., et al. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-17059-4 · Cited by 1
Cannabinoids and Endocannabinoids
Jung, K., & Piomelli, D. (2022) · Springer eBooks · doi:10.1007/978-3-030-88832-9_136 · Cited by 1
Cannabinoids and drugs of abuse
Parolaro, D., & Rubino, T. (2005) · Birkhäuser-Verlag eBooks · doi:10.1007/3-7643-7358-x_12 · Cited by 1
SPECIAL ISSUE ARTICLE ROLE OF THE ENDOCANNABINOID SYSTEM IN THE DEVELOPMENT OF TOLERANCE TO ALCOHOL
Basavarajappa, B. S., & Hungund, B. L. (2005) · Cited by 1
Role of the Endocannabinoid System in Extinction of Learned Behaviours Motivated by Opioid-Induced Reward and Aversion in Rats
Manwell, L. A. (2013) · The Atrium (University of Guelph) · Cited by 1
Le rimonabant (Acomplia®), inhibiteur spécifique du système endocannabinoïde
Ducobu, J., & Sternon, J. (2005) · Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) · Cited by 1
Nicotine
Buchhalter, A. R., Fant, R. V., & Henningfield, J. E. (2007) · Wiley eBooks · doi:10.1002/9780470101001.hcn037 · Cited by 1
Cannabis Co-Use and Endocannabinoid System Modulation in Tobacco Use Disorder: A Translational Systematic Review and Meta-AnalysisPreprint
Costa, G. P. A., Gómez, Ó., Rocha, L. R., Cerezo-Matias, M. A., Funaro, M. C., Bağdaş, D., Sofuoglu, M., & Aquino, J. P. D. (2026) · medRxiv · doi:10.64898/2026.02.12.26346166 · Cited by 1
Chronic treatment with simvastatin affects cannabinoid receptor type 1 and muscarinic receptors type 2/4 in different brain regions among sham and 6-hydroxydopamine lesioned rats
Mackovski, N. (2013) · Research Online (University of Wollongong)
Effets motivationnels de la nicotine chez le rat. Implication des endocannabinoïdes et d'autres systèmes de neurotransmission.
Forget, B. (2007) · HAL
Estudo neurofarmacológico da interação entre circuitos endocanabinoides e opioides da substância negra, parte reticulada, sobre a atividade da via GABAérgica Nigro-Tectal, e de seu papel na modulação da analgesia induzida pelo medo inato
da Silva, J. A. (2011) · doi:10.11606/d.17.2011.tde-14082013-123119
Valor de los polimorfismos de los genes CHRNA3A5B4 en la adicción al tabaco. Influencia de los mismos en el proceso de adicción.
Barrios, M. J. (2012) · Gredos (University of Salamanca) · doi:10.14201/gredos.115538
L’association tabac-cannabis est-elle susceptible de modifier l’histoire naturelle de la dépendance ?
Àfif, H., Urban, T., Quantin, X., & Abraham, M. (2010) · Revue des Maladies Respiratoires Actualités · doi:10.1016/s1877-1203(10)70099-9
Actualité des thérapeutiques pharmacologiques et perspectives d’avenir
Dautzenberg, B. (2006) · Revue des Maladies Respiratoires · doi:10.1016/s0761-8425(06)73423-4
Novel Pharmacological Treatment Alternatives for Nicotine Dependence
Lindblom, N. (2005) · Figshare
Discriminative stimulus properties of 3-substituent rimonabant analogs
Walentiny, D. M. (2011) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/m6nv-8e37
Promising pharmacotherapy on the horizon for nicotine dependence.
Berrettini, W. H. (2005) · PubMed Central
The Metabolic Effects of Conjugated Linoleic Acids (CLA) in Chickens: A Review
Royan, M., & Navidshad, B. (2015) · Iranian journal of applied animal science
The role of cannabinoid system in the behavioral effects of nicotine
Biała, G. (2008) · Annales UMCS Pharmacia · doi:10.2478/v10080-008-0094-x
Prevenzione delle Malattie Cardiovascolari Work in Progress 2007
Cardiovascolari, P. D. M. (2016) · Monaldi Archives for Chest Disease · doi:10.4081/monaldi.2007.473
Treatment of Nicotine Dependence
Foll, B. L. (2006) · CRC Press eBooks · doi:10.1201/9781420005431.ch21
Animal Models of Nicotine Addiction
Steiner, R. C., & Picciotto, M. R. (2006) · CRC Press eBooks · doi:10.1201/9781420005431.ch3
The role of the cannabinoid system in the neurochemistry underlying reward processes
Kleijn, J. (2013) · University of Groningen research database (University of Groningen / Centre for Information Technology)
ANALES DE LA REAL ACADEMIA NACIONAL DE FARMACIA
Santos‐Moriano, P., Fernández‐Arrojo, L., Rodríguez-Colinas, B., & Plou, F. J. (2016)
Cannabinoids and the Addictive Effects of Nicotine
Panlilio, L. V., & Goldberg, S. R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-800756-3.00087-9
Role of the Cannabinoid System in Modulating the Reinforcing and Relapse Related Properties of Nicotine in Rats
Gamaleddin, I. (2013) · TSpace (University of Toronto)
The Involvement of Ventral Tegmental Area Dopamine and CRF Activity in Mediating the Opponent Motivational Effects of Acute and Chronic Nicotine
Grieder, T. E. (2012) · TSpace (University of Toronto)
Nicotine Dependence
David, S. P., McClure, J. B., & Swan, G. E. (2012) · Wiley eBooks · doi:10.1002/9781118133880.hop209007
Diagnose von Missbrauch und Abhängigkeit
Lesch, O., Walter, H., Hesselbrock, M. N., & HESSELBROCK, V. M. (2020) · Springer eBooks · doi:10.1007/978-3-662-60284-3_5
Therapeutische Strategien bei Alkohol- und Tabakabhängigkeit
Lesch, O., Walter, H., Pombo›, S., HESSELBROCK, V. M., & Hesselbrock, M. N. (2020) · Springer eBooks · doi:10.1007/978-3-662-60284-3_9
Medikamentöse Behandlung des Rauchers
Haustein, K.-O. (2008) · Springer eBooks · doi:10.1007/978-3-540-73309-6_13
Ghrelin, Cannabinoids, and Motivation: Increased Food Motivation on Progressive Ratio Paradigm Through MAGL/FAAH Inhibition in a Rat Model
Sante, S. D. (2022) · doi:10.22215/etd/2022-14843
Implicación de la monoamino oxidasa en conductas inducidas por etanol
Ayuso, M. Á. E. (2016) · doi:10.6035/11610.2016.159812
Diagnosis of Abuse and Addiction
Lesch, O., Walter, H., Wetschka, C., Hesselbrock, M. N., HESSELBROCK, V. M., & Pombo›, S. (2020) · Springer eBooks · doi:10.1007/978-3-030-41941-7_5
Behavioral Phenotyping From deleted CB1 Receptors on Cholinergic Neuron TerminalsPreprint
Wu, S., Tsutsui, K., & Fitoussi, A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.06.495026
Impact of Δ9-tetrahydrocannabinol (THC) and synthetic “spice” cannabinoids on nicotine use and abuse
Dukes, A. J., Bautista, M. R., & Fowler, C. D. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-89862-1.00014-3
Role of anandamide in nicotine addiction
Foll, B. L. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-19081-0.00015-9
The role of the endocannabinoid system in attention and nicotine addiction
van Klinken, W. P. (2011) · Utrecht University Repository (Utrecht University)
FIGURES 45. Axinyssa djiferi spec. nov. 4 in A new species of Axinyssa Lendenfeld, 1897 (Porifera, Demospongiae, Halichondrida) from the Senegalese coast
Boury‐Esnault, N., Marschal, C., Probst, J.-M. K., & Barnathan, G. (2002) · INFM-OAR (INFN Catania) · doi:10.5281/zenodo.155630
Étude électrophysiologique des effets du tabac, de sa fumée et de la nicotine sur des neurones dopaminergiques de l’aire tegmentale ventrale in vivo chez le rat, la souris sauvage et la souris β2 KO
Arib, O. (2009) · theses.fr (ABES) · doi:10.70675/b585acc3z0d1cz4458zb20azdc445f0b7743
Role of the type-1 cannabinoid receptor in the control of water intake
Zhao, Z. (2019) · theses.fr (ABES) · doi:10.70675/ca103186z8d92z4d94zaf67zcce657f39cd1
Role of the endocannabinoid system in exercise motivation
Redon, B. (2021) · theses.fr (ABES) · doi:10.70675/844c9d99zd3c6z4550z97a6zebab239b226c
Modulation of Dopamine Release Sculpts Ethologically Relevant Motivated Actions Through the Computation of Conditioned Stimuli
Oleson, E. B., & Cheer, J. F. (2026) · Springer eBooks · doi:10.1007/978-3-032-12239-1_8
Cannabinoid–Nicotine Interactions in Nicotine Addiction: Preclinical Evidence
Rodríguez‐Borillo, O., & Scherma, M. (2026) · Springer eBooks · doi:10.1007/978-3-032-12239-1_13
Associations of endocannabinoid serum concentrations with behavioral impulsivity and substance use in late childhood to early adolescence
Shankula, C. A., Sullivan, R. M., Stinson, E. A., Baacke, K. A., Kaiver, C. M., Wallace, A. L., Bernal, E. S., Paltzer, Z. R., Hillard, C. J., & Lisdahl, K. M. (2026) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2026.113184
Cannabis Co-use and endocannabinoid system modulation in tobacco use disorder
Costa, G. P. A., Gómez, O., Rocha, L. R., Cerezo-Matias, M. A., Funaro, M. C., Bagdas, D. D., Sofuoglu, M., & Aquino, J. P. D. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.107032 · Cited by 1
BindingDB Entry 5466: SR147778 [5-(4-bromophenyl)-1-(2,4-dichlorophenyl)-4-ethyl-N-(1-piperidinyl)-1H-pyrazole-3-carboxamide], a new potent and selective antagonist of the CB1 cannabinoid receptor: biochemical and pharmacological characterization.
BindingDB (2012) · UC San Diego · doi:10.7270/q2rr1wtx
BindingDB Entry 5412: SSR591813, a novel selective and partial alpha4beta2 nicotinic receptor agonist with potential as an aid to smoking cessation.
BindingDB (2012) · UC San Diego · doi:10.7270/q2gm85wx
BindingDB Entry 50008265: Divalent cannabinoid-1 receptor ligands: A linker attachment point survey of SR141716A for development of high-affinity CB1R molecular probes.
BindingDB (2021) · UC San Diego · doi:10.7270/q2qv3qw7
BindingDB Entry 50026938: Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antagonists.
BindingDB (2010) · UC San Diego · doi:10.7270/q24m94bm
BindingDB Entry 50016057: Substituted 5,5'-diphenyl-2-thioxoimidazolidin-4-one as CB1 cannabinoid receptor ligands: synthesis and pharmacological evaluation.
BindingDB (2009) · UC San Diego · doi:10.7270/q2q23zrd

Authors: Cohen, C., Perrault, G., Voltz, C., Steinberg, R., & Soubrié, P.
Affiliations: Sanofi (France) (FR)
Corresponding author: Cohen, C.
Venue: Behavioural Pharmacology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2002-09
Volume: 13
Issue: 5
Pages: 451-463
ISSN: 0955-8810 (ISSN-L)
DOI: 10.1097/00008877-200209000-00018
OpenAlex: W2001109168
Cited by: 396
References: 77
Citations by year: 2026: 5 · 2025: 2 · 2024: 4 · 2023: 11 · 2022: 9 · 2021: 7 · 2020: 13 · 2019: 8 · 2018: 8 · 2017: 11 · 2016: 20 · 2015: 14 · 2014: 9 · 2013: 19 · 2012: 16
FWCI: 16.34
Type: journal article
Language: en
Open access: closed
Locations: Behavioural Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
Keywords: SR141716, nicotine self-administration, dopamine release, nucleus accumbens shell, bed nucleus of the stria terminalis, endocannabinoid system, drug reward, alcohol consumption reduction, smoking cessation
MeSH terms: Rimonabant, Ethanol, Animals, Brain Chemistry, Central Nervous System Depressants, Discrimination Learning, Dopamine, Extracellular Space, Male, Motivation, Nicotine, Nucleus Accumbens, Piperidines, Pyrazoles, Receptors, Drug, Reinforcement, Psychology, Self Administration, Rats, Sprague-Dawley, Rats, Wistar, Microdialysis, Nicotinic Agonists, Nicotinic Antagonists, Receptors, Cannabinoid, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

SR141716, a central cannabinoid (CB1) receptor antagonist, blocks the motivational and dopamine-releasing effects of nicotine in rats

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks