Macrophages, lipoprotein metabolism, and atherosclerosis: insights from murine bone marrow transplantation studies
Abstract
The macrophage expresses a variety of genes that may contribute to lipoprotein metabolism and atherosclerotic lesion formation. Bone marrow transplantation experiments using gene-targeted mice, both as donors and recipients, provide a useful approach to examine the contribution of macrophage gene expression to lipoprotein metabolism and atherogenesis in vivo. This article describes recent insights into the role of macrophage expression of apolipoprotein E and the LDL receptor gained from bone marrow transplantation studies in the mouse.
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Human apoE is present on nearly all serum lipoproteins and plays a protective role in atherosclerosis by acting both as a ligand for receptor-mediated lipoprotein clearance and as an acceptor for cholesterol exported by peripheral cells.
“Human apoE is present on nearly all serum lipoproteins and plays a protective role in atherosclerosis by acting both as a ligand for receptor-mediated lipoprotein clearance and as an acceptor for cholesterol exported by peripheral cells ( 1,2 ).”
From Macrophage-derived apoESendai suppresses atherosclerosis while causing lipoprotein glomerulopathy in hyperlipidemic mice (2014) · cites this paper as [2]
Bone marrow transplantation is a reliable and validated approach to study the effect of changes in macrophage gene expression on atherosclerosis in the mouse.
“Bone marrow transplantation is a reliable and validated approach to study the effect of changes in macrophage gene expression on atherosclerosis in the mouse ( 2,11 ).”
From Macrophage-derived apoESendai suppresses atherosclerosis while causing lipoprotein glomerulopathy in hyperlipidemic mice (2014) · cites this paper as [2]
Cites
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Phenotypes of apolipoprotein B and apolipoprotein E after liver transplantation.
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Self-citationJi, Z.-S., Pitas, R. E., & Mahley, R. W. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13452 · Cited by 134 · see citing works
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Tavori, H., Fan, D., Giunzioni, I., Zhu, L., Linton, M. F., Fogo, A. B., & Fazio, S. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m049874 · Cited by 10 · see citing works
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- Authors
- Linton, M. F., & Fazio, S.
- Affiliations
- Vanderbilt University Medical Center (US)
- Venue
- Current Opinion in Lipidology
- Published
- 1999-04
- Volume
- 10
- Issue
- 2
- Pages
- 97-106
- ISSN
- 0957-9672 (ISSN-L)
- OpenAlex
- W2032561094
- Cited by
- 51
- References
- 5
- Citations by year
- 2024: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 6 · 2014: 1 · 2013: 3 · 2012: 3
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Lipidology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL057986, HL57986, HL 53989, R01HL053989)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- macrophages, lipoprotein metabolism, atherosclerosis, atherogenesis, apolipoprotein E, LDL receptor, gene-targeted mice, bone marrow transplantation, macrophage gene expression
- MeSH terms
- Animals, Aorta, Apolipoproteins E, Arteriosclerosis, Foam Cells, Leukocytes, Lipoproteins, Macrophages, Models, Biological, Receptors, LDL, Bone Marrow Transplantation, Mice
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