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Immunologic responses to common antigens in helminthic infections and allergic disease
Abstract
Purpose of review It is estimated that over 1 billion individuals are infected with helminth parasites worldwide. Epidemiologic studies have pointed to a protective role of helminthic infections in the development of allergy and asthma; however, evidence for this inverse association has not been consistently established. The focus of this review is to discuss the potential role of shared antigens between parasites and environmental allergens in modulating allergic immune responses, specifically tropomyosin. Recent findings Tropomyosin has been identified as a highly conserved molecule in invertebrates. In populations exposed concomitantly to mites, cockroach, Ascaris, and shrimp and other crustaceans and mollusks, IgE antibody responses to tropomyosin are found in over 50% of individuals. Evidence suggests that IgE cross-reactivity to tropomyosin has clinical relevance. Summary Mechanisms underlying the immunomodulatory effects of parasites in allergy and asthma remain poorly understood. Identification of molecules in intestinal parasites, particularly Schistosoma mansoni and Ascaris lumbricoides, associated with protection from or promotion of allergy and asthma, could provide the basis for novel forms of treatment or prevention of these diseases. Prospective studies will be necessary to clarify the role of tropomyosin and other parasite antigens shared with inhalant or food allergens in the development of allergic diseases.
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“These bacteria produce short-chain fatty acids (SCFAs), which, in turn, can stimulate Treg populations.”
From Parasites and allergies: a complex bidirectional relationship from evolutionary origins to modern therapeutics (2026) · cites this paper as Arruda and Santos 2005
In the citing paper
“For instance, during chronic nematode infections, studies have shown increased colonization of the small intestine by Lactobacillus species and increased growth of Clostridium species in the large intestine.”
From Parasites and allergies: a complex bidirectional relationship from evolutionary origins to modern therapeutics (2026) · cites this paper as Arruda and Santos 2005
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“Changes in the microbiome induced by parasites may also influence the risk of food allergies and other allergic conditions.”
From Parasites and allergies: a complex bidirectional relationship from evolutionary origins to modern therapeutics (2026) · cites this paper as Arruda and Santos 2005
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Research works printed but not linked: 21
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Interactions between helminth parasites and allergy
Cooper, P. J. (2009) · Current Opinion in Allergy & Clinical Immunology · doi:10.1097/aci.0b013e32831f44a6 · Cited by 202
Packi, K., Świerczewski, D., Klimczak, S., Ochab, D., Gałęziewska, J., Gromek, P., Kruczkowska, W., Płuciennik, E., Kałuzińska-Kołat, Ż., & Kołat, D. (2026) · Antonie van Leeuwenhoek · doi:10.1007/s10482-026-02425-4
Metadata
- Authors
- Arruda, L. K., & Santos, A. B. R.
- Venue
- Current Opinion in Allergy & Clinical Immunology
- Published
- 2005-10
- Volume
- 5
- Issue
- 5
- Pages
- 399-402
- ISSN
- 1528-4050
- Cited by
- 39
- References
- 0
- Language
- en
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- Arruda, L. K., & Santos, A. B. R. (2005). Immunologic responses to common antigens in helminthic infections and allergic disease. Current Opinion in Allergy & Clinical Immunology. https://doi.org/10.1097/01.all.0000182536.55650.d0
