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A Mouse Model of Angiotensin II Slow Pressor Response: Role of Oxidative Stress
Abstract
ABSTRACT. The slow pressor response to prolonged infusions of angiotensin II (AngII) entails a delayed rise in BP. This study investigated the hypothesis that the response depends on the generation of oxidative stress. The BP and renal functional response of mice to graded doses (200, 400, and 1000 ng. kg(-1). min(-1)) of subcutaneously infused AngII was studied. The SBP of conscious mice increased by day 3 at AngII1000 but showed a delayed rise by days 9 to 13 (slow pressor response) at the lower rates of AngII infusion. By day 13, there was a graded increase in SBP with the rate of AngII infusion (Vehicle, -2.6 +/- 2.6%; AngII200, +14.1 +/- 5.0%; AngII400, +31.9 +/- 1.9%; AngII1000, +43.2 +/- 5.5%). The MAP measured under anesthesia rose significantly (P < 0.001) with AngII400 at 14 d (Vehicle, 85 +/- 2 mmHg; AngII400, 100 +/- 3 mmHg). When studied at day 6, the MAP of AngII400 rats was not elevated (88 +/- 2 mmHg; NS versus vehicle), yet the GFR was higher (1.05 +/- 0.05 versus 1.25 +/- 0.05 ml. min(-1). g(-1); P < 0.05) accompanied by an increase in the filtration fraction (FF) (28.8 +/- 1.2 versus 37.2 +/- 0.8%; P < 0.001). From day 6 through day 14, the MAP had increased (P < 0.01) in AngII400, accompanied by a significant reduction in GFR to 1.05 +/- 0.04 ml. min(-1). g(-1) (P < 0.01) and elevation of renal vascular resistance (RVR) (day 6 versus day 14, 15.3 +/- 0.6 versus 19.2 +/- 1.2 mmHg. ml(-1). min(-1). g(-1); P < 0.05). Renal excretion of 8-iso PGF(2alpha) was increased in AngII400 group at day 12 (2.52 +/- 0.35 versus 5.85 +/- 0.78 pg. day(-1); P < 0.01). The permeant superoxide dismutase mimetic tempol reduced the effects of AngII400 on the SBP (-1.7 +/- 5.8%; P < 0.01), the MAP (87 +/- 4 mmHg; P < 0.01), and the RVR (15.2 +/- 0.5 mmHg. ml(-1). min(-1). g(-1); P < 0.05) at day 14 and the renal 8-iso PGF(2alpha) excretion (3.53 +/- 0.71 pg. d(-1); P < 0.05) at day 12. It is concluded that the AngII infused mouse is a valid model for the slow pressor response. There is an early rise in GFR and FF, consistent with increased postglomerular vascular resistance and a late rise in RVR with a fall in GFR, consistent with increased preglomerular vascular resistance that is accompanied by a rise in BP. There is evidence of increased oxidative stress that is implicated in the increase in the BP and RVR in this model.
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“Administration of low doses of ANGII for 2 weeks, which results in a slow-developing rise in BP (“slow pressor” hypertension) (14), induces profound alterations in neurovascular coupling and endothelium-dependent vasodilation (10,15).”
From Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension (2016) · cites this paper as [14]
Citations
Cites
Rajagopalan, S., Kurz, S. D., Münzel, T. F., Tarpey, M. M., Freeman, B. Α., Griendling, K. K., & Harrison, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118623 · Cited by 2,467
Morrow, J. D., Hill, K. E., Burk, R. F., Nammour, T., Badr, K. F., & Roberts, L. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.23.9383 · Cited by 1,898
A Light and Electron Microscopic Study
Schochet, S. S., McCermick, W. F., & F, G. F. (1976) · Cited by 1,642
Role of Superoxide in Angiotensin II–Induced but Not Catecholamine-Induced Hypertension
Laursen, J. B., Rajagopalan, S., Galis, Z. S., Tarpey, M. M., Freeman, B. Α., & Harrison, D. G. (1997) · Circulation · doi:10.1161/01.cir.95.3.588 · Cited by 820
Schnackenberg, C. G., Welch, W. J., & Wilcox, C. S. (1998) · Hypertension · doi:10.1161/01.hyp.32.1.59 · Cited by 498
Self-citationIsoprostanes: Formation, Analysis and Use As Indices of Lipid Peroxidation in Vivo
Lawson, J. A., FitzGerald, G. A., & Rokach, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.24441 · Cited by 381
Chabrashvili, T., Tojo, A., Onozato, M. L., Kitiyakara, C., Quinn, M. T., Fujita, T., Welch, W. J., & Wilcox, C. S. (2002) · Hypertension · doi:10.1161/hy0202.103264 · Cited by 377
Self-citationSchnackenberg, C. G., & Wilcox, C. S. (1999) · Hypertension · doi:10.1161/01.hyp.33.1.424 · Cited by 375
Self-citationWeiss, D., Kools, J. J., & Taylor, W. R. (2001) · Circulation · doi:10.1161/01.cir.103.3.448 · Cited by 370
Role of Angiotensin and Oxidative Stress in Essential Hypertension
Romero, J. C., & Reckelhoff, J. F. (1999) · Hypertension · doi:10.1161/01.hyp.34.4.943 · Cited by 358
Chatterjee, P. K., Cuzzocrea, S., Brown, P. A., Zacharowski, K. D., Stewart, K. N., Mota‐Filipe, H., & Thiemermann, C. (2000) · Kidney International · doi:10.1046/j.1523-1755.2000.00212.x · Cited by 352
Grunfeld, S., Hamilton, C. A., Mesaros, S. V., McClain, S. W., Dominiczak, A. F., Bohr, D. F., & Maliñski, T. (1995) · Hypertension · doi:10.1161/01.hyp.26.6.854 · Cited by 300
Ichihara, S., Senbonmatsu, T., Price, E., Ichiki, T., Gaffney, F. A., & Inagami, T. (2001) · Circulation · doi:10.1161/01.cir.104.3.346 · Cited by 297
Mitchell, J. B., DeGraff, W., Kaufman, D., Krishna, M. C., Samuni, A., Finkelstein, E., Ahn, M. S., Hahn, S. M., Gamson, J., & Russo, A. (1991) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(91)90442-l · Cited by 228
Tempol, a stable free radical, is a novel murine radiation protector.
Hahn, S. M., Tochner, Z. A., Krishna, C. M., Glass, J. D., Wilson, L., Samuni, A., Sprague, M., Venzon, D. J., GLATSTEIN, E. J., & Mitchell, J. B. (1992) · PubMed · Cited by 212
Inhibition of Lipid Peroxidation by Spin Labels
Nilsson, U. A., Olsson, L. I., Carlin, G., & Bylund‐Fellenius, A. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60439-9 · Cited by 176
Roles of NO and oxygen radicals in tubuloglomerular feedback in SHR
Welch, W. J., Tojo, A., & Wilcox, C. S. (2000) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2000.278.5.f769 · Cited by 171
Self-citationUpregulation of p67phoxand gp91phoxin aortas from angiotensin II-infused mice
Cifuentes-Pagano, E., Rey, F. E., Carretero, O. A., & Pagano, P. J. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.279.5.h2234 · Cited by 168
Role of superoxide anions in the mediation of endothelium-dependent contractions.
Cosentino, F., Sill, J. C., & Katušić, Z. S. (1994) · Hypertension · doi:10.1161/01.hyp.23.2.229 · Cited by 165
Yura, T., Fukunaga, M., Khan, R., Nassar, G., Badr, K. F., & Montero, A. (1999) · Kidney International · doi:10.1046/j.1523-1755.1999.00596.x · Cited by 155
Dickinson, C. J., & Lawrence, J. R. (1963) · The Lancet · doi:10.1016/s0140-6736(63)91929-9 · Cited by 136
Antioxidants Block Angiotensin II-Induced Increases in Blood Pressure and Endothelin
Ortíz, M. C., Manriquez, M. C., Romero, J. C., & Juncos, L. A. (2001) · Hypertension · doi:10.1161/01.hyp.38.3.655 · Cited by 134
The SOD mimetic tempol restores vasodilation in afferent arterioles of experimental diabetes
Schnackenberg, C. G., & Wilcox, C. S. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.0590051859.x · Cited by 125
Self-citationAT1 receptor antagonist combats oxidative stress and restores nitric oxide signaling in the SHR
Welch, W. J., & Wilcox, C. S. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.0590041257.x · Cited by 115
Self-citationHypokalemia induces renal injury and alterations in vasoactive mediators that favor salt sensitivity
Suga, S., Phillips, M. I., Ray, P. E., Raleigh, J. A., Vio, C. P., Kim, Y.-G., Mazzali, M., GORDON, K. L., Hughes, J., & Johnson, R. J. (2001) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2001.281.4.f620 · Cited by 112
Dobrian, A. D., Schriver, S. D., & Prewitt, R. L. (2001) · Hypertension · doi:10.1161/01.hyp.38.3.361 · Cited by 99
Comparison of fast and slow pressor effects of angiotensin II in the conscious rat
Brown, A. J., CASALS‐STENZEL, J., Gofford, S., Lever, A. F., & Morton, J. J. (1981) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1981.241.3.h381 · Cited by 95
Metabolism in rat liver microsomes of the nitroxide spin probe tempol
Iannone, A., Bini, A., Swartz, H. M., Tomasi, A., & Vannini, V. (1989) · Biochemical Pharmacology · doi:10.1016/0006-2952(89)90541-8 · Cited by 92
Subpressor Doses of Angiotensin II Increase Plasma F 2 -Isoprostanes in Rats
Reckelhoff, J. F., Zhang, H., Srivastava, K., Roberts, L. J., Morrow, J. D., & Romero, J. C. (2000) · Hypertension · doi:10.1161/01.hyp.35.1.476 · Cited by 88
Low-Dose Angiotensin II Increases Free Isoprostane Levels in Plasma
Haas, J. A., Krier, J. D., Bolterman, R. J., Juncos, L. A., & Romero, J. C. (1999) · Hypertension · doi:10.1161/01.hyp.34.4.983 · Cited by 81
TP receptor-mediated vasoconstriction in microperfused afferent arterioles: roles of O2−and NO
Schnackenberg, C. G., Welch, W. J., & Wilcox, C. S. (2000) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.2000.279.2.f302 · Cited by 79
Self-citationRole of Endothelin and Isoprostanes in Slow Pressor Responses to Angiotensin II
Ortíz, M. C., Sanabria, E., Manriquez, M. C., Romero, J. C., & Juncos, L. A. (2001) · Hypertension · doi:10.1161/01.hyp.37.2.505 · Cited by 75
Renoprotective effects of nitric oxide in angiotensin II-induced hypertension in the rat
Chin, S. Y., Wang, C.-T., Majid, D. S. A., & Navar, L. G. (1998) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1998.274.5.f876 · Cited by 74
Role of Nitric Oxide in Short-term and Prolonged Effects of Angiotensin II on Renal Hemodynamics
Deng, X., Welch, W. J., & Wilcox, C. S. (1996) · Hypertension · doi:10.1161/01.hyp.27.5.1173 · Cited by 73
Self-citationMorphologic aspects of low-potassium and low-sodium nephropathy.
Riemenschneider, T., & Bohle, A. (1983) · PubMed · Cited by 68
Thromboxane mediates renal hemodynamic response to infused angiotensin II
Wilcox, C. S., Welch, W. J., & Snellen, H. G. (1991) · Kidney International · doi:10.1038/ki.1991.319 · Cited by 68
Self-citationAngiotensin II–Induced Hypertension in Bradykinin B 2 Receptor Knockout Mice
Červenka, L., Malý, J., Karasová, L., Šimová, M., Vitko, S., Hellerová, S., Heller, J., & El-Dahr, S. S. (2001) · Hypertension · doi:10.1161/01.hyp.37.3.967 · Cited by 68
Bean, B. L., Brown, J. J., CASALS‐STENZEL, J., Fräser, R., Lever, A. F., Millar, J. A., Morton, J. J., Petch, B., Riegger, A. J. G., Robertson, J. I. S., et al. (1979) · Circulation Research · doi:10.1161/01.res.44.4.452 · Cited by 67
Interaction between nitric oxide and oxygen radicals in regulation of tubuloglomerular feedback
Wilcox, & Welch (2000) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2000.00668.x · Cited by 61
Renal mechanisms of angiotensin II-induced hypertension.
Granger, J. P., & Schnackenberg, C. G. (2000) · PubMed · Cited by 58
HYPOKALEMIC NEPHROPATHY IN RAT AND MAN: A LIGHT AND ELECTRON MICROSCOPIC STUDY.
Muehrcke, R. C., & ROSEN, S. (1964) · PubMed · Cited by 50
AT1 and TxA2/PGH2 receptors maintain hypertension throughout 2K,1C Goldblatt hypertension in the rat
Wilcox, C. S., Cardozo, J., & Welch, W. J. (1996) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1996.271.4.r891 · Cited by 41
Self-citationRole of nNOS in Regulation of Renal Function in Angiotensin II–Induced Hypertension
Červenka, L., Kramer, H. J., Malý, J., & Heller, J. (2001) · Hypertension · doi:10.1161/01.hyp.38.2.280 · Cited by 33
Nitroxide Radicals Prevent Metal-aggravated Reperfusion Injury in Isolated Rat Heart
Zeltcer, G., Berensritin, E., Samuni, A., & Chevion, M. (1997) · Free Radical Research · doi:10.3109/10715769709097866 · Cited by 28
Angiotensin II Infused Intrarenally Causes Preglomerular Vascular Changes and Hypertension
Stevenson, K. M., Edgley, A. J., Bergström, G. M. L., Worthy, K. H., Kett, M. M., & Anderson, W. P. (2000) · Hypertension · doi:10.1161/01.hyp.36.5.839 · Cited by 27
Sympathetic nervous system and hypertension during prolonged TxA2/PGH2 receptor activation in rats
Gao, H., Welch, W. J., DiBona, G. F., & Wilcox, C. S. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.2.h734 · Cited by 17
Self-citationHypokalemic states: current clinical issues.
Krishna, G. G. (1990) · PubMed · Cited by 7
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Wilcox, C. S. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00250.2005 · Cited by 482
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Wilcox, C. S. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.01.003 · Cited by 478
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Metadata
- Authors
- Kawada, N., Imai, E., Karber, A., Welch, W. J., & Wilcox, C. S.
- Affiliations
- Georgetown University (US)
- The University of Osaka (JP)
- Corresponding author
- Kawada, Noritaka
- Welch, William J.
- Wilcox, Christopher S.
- Venue
- Journal of the American Society of Nephrology
- Published
- 2002-12
- Volume
- 13
- Issue
- 12
- Pages
- 2860-2868
- ISSN
- 1046-6673 (ISSN-L)
- OpenAlex
- W2127905773
- Cited by
- 195
- References
- 47
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 7 · 2019: 4 · 2018: 8 · 2017: 7 · 2016: 11 · 2015: 8 · 2014: 8 · 2013: 7 · 2012: 9
- FWCI
- 7.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of the American Society of Nephrology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL‐68686, P01HL068686)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK‐49870, DK 36079, R01DK049870)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- angiotensin II, oxidative stress, blood pressure, renal function, glomerular filtration rate, filtration fraction, renal vascular resistance, renal excretion, rats, infusion rate, renal hemodynamics, nitric oxide synthase inhibition, angiotensin II receptor, renin-angiotensin system
- MeSH terms
- Angiotensin II, Animals, Antioxidants, Blood Pressure, Cyclic N-Oxides, Dose-Response Relationship, Drug, Drug Administration Schedule, Drug Combinations, Infusion Pumps, Kidney, Male, Mice, Inbred C57BL, Spin Labels, Systole, Vasoconstrictor Agents, Dinoprost, Oxidative Stress, F2-Isoprostanes, Mice
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