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Cited by 119Spine and Intervertebral Disc PathologyMusculoskeletal pain and rehabilitationPain Mechanisms and Treatments

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

The Efficiency of Gabapentin Therapy in Patients With Lumbar Spinal Stenosis

Yaksi, Ali, Özgönenel, Levent, Özgönenel, Bülent·2007·Spine
DOI 10.1097/01.brs.0000261029.29170.e6
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Abstract

In Brief Study Design. Randomized controlled study. Objectives. To investigate the efficacy of treatment with gabapentin on the clinical symptoms and findings in patients with lumbar spinal stenosis (LSS). Summary of Background Data. LSS is a syndrome resulting from the narrowing of the lumbar nerve root canal, spinal canal, and intervertebral foramen, causing compression of the spinal cord. The most significant clinical symptom in patients with LSS is neurologic intermittent claudication (NIC). Gabapentin, which has been used in the treatment of neuropathic pain, may be effective in the treatment of symptoms associated with LSS. Methods. Fifty-five patients with LSS, who had NIC as the primary complaint, were randomized into 2 groups. All patients were treated with therapeutic exercises, lumbosacral corset with steel bracing, and nonsteroidal anti-inflammatory drugs. The treatment group received gabapentin orally in addition to the standard treatment. Results. Gabapentin treatment resulted in an increase in the walking distance better than what was obtained with standard treatment (P = 0.001). Gabapentin-treated patients also showed improvements in pain scores (P = 0.006) and recovery of sensory deficit (P = 0.04), better than could be attained with the standard treatment. Conclusion. Based on the results of our pilot study, extensive clinical studies are warranted to investigate the role of gabapentin in the management of symptomatic LSS. Fifty-five patients with lumbar spinal stenosis were randomized to receive oral gabapentin or nothing along with the standard treatment. Patients receiving gabapentin showed superior reduction in pain scores and increased their walking distance when compared with control patients. Gabapentin should be considered in the treatment of lumbar spinal stenosis.

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Crossref · 10.1097/01.brs.0000261029.29170.e6

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Research works printed but not linked: 2

  1. Wiffen, 2005, Cochrane Database Syst Rev, 3, CD005452
  2. Blonna, 2004, Minerva Ortop Traumatol, 55, 15

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Metadata

Authors
Yaksi, A., Özgönenel, L., & Özgönenel, B.
Affiliations
  • İstanbul Fizik Tedavi ve Rehabilitasyon Eğitim ve Araştırma Hastanesi (TR)
  • Ministry of Health (TR)
  • Corewell Health William Beaumont University Hospital (US)
Corresponding author
  • Yaksi, Ali
  • Özgönenel, Levent
ORCID
Venue
Spine
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2007-04
Volume
32
Issue
9
Pages
939-942
ISSN
0362-2436 (ISSN-L)
DOI
10.1097/01.brs.0000261029.29170.e6
OpenAlex
W2077668511
Cited by
118
References
15
Citations by year
2026: 3 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 10 · 2021: 3 · 2020: 7 · 2019: 9 · 2018: 3 · 2017: 9 · 2016: 7 · 2015: 7 · 2014: 8 · 2013: 6 · 2012: 2
FWCI
5.89
Type
journal article
Language
en
Open access
closed
Locations
  • Spine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Spine and Intervertebral Disc Pathology
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Keywords
gabapentin, lumbar spinal stenosis, neurogenic claudication, neuropathic pain, walking distance, pain scores, sensory impairment, nonsteroidal anti-inflammatory drugs, exercise therapy, lumbar nerve root compression
MeSH terms
Gabapentin, Adult, Aged, Amines, Analgesics, Back Pain, Cyclohexanecarboxylic Acids, Female, gamma-Aminobutyric Acid, Humans, Lumbar Vertebrae, Male, Middle Aged, Pain Measurement, Pilot Projects, Spinal Stenosis, Walking

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.