The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Effects of storage on efficacy of red cell transfusion: When is it not safe?
Abstract
OBJECTIVE: To review the literature on red blood cell storage and its relationship to the efficacy of transfusion. RESULTS: Well-documented changes occur to the red blood cell product during ex vivo storage. These changes include a reduction in red blood cell deformability, altered red blood cell adhesiveness and aggregability, and a reduction in 2,3-diphosphoglycerate and ATP. Bioactive compounds with proinflammatory effects also accumulate in the storage medium. These changes reduce posttransfusion viability of red blood cells. The clinical effects beyond posttransfusion viability are uncertain, but a growing body of evidence suggests that the storage lesion may reduce tissue oxygen availability, have proinflammatory and immunomodulatory effects, and influence morbidity and mortality. There are no published randomized, control trials examining the effect of storage duration on morbidity and mortality. Leukoreduction improves the quality of stored red blood cell products and in some studies has been shown to reduce morbidity and mortality. CONCLUSION: Although storage duration influences the quality of red blood cell product, there is currently insufficient evidence to advocate shorter storage periods for red blood cell products.
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Cites
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Cited by
Duration of Red-Cell Storage and Complications after Cardiac Surgery
Koch, C. G., Li, L., Sessler, D. I., Figueroa, P., Hoeltge, G. A., Mihaljevic, T., & Blackstone, E. H. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa070403 · Cited by 1,363
James, A. H., Jamison, M. G., Brancazio, L. R., & Myers, E. R. (2006) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2005.11.008 · Cited by 979
Efficacy of red blood cell transfusion in the critically ill: A systematic review of the literature*
Marik, P. E., & Corwin, H. L. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181844677 · Cited by 913
Clinical consequences of red cell storage in the critically ill
Tinmouth, A., Fergusson, D., Yee, I. C., Hébert, P. C., & ABLE Investigators and the Canadian Critical Care Trials Group (2006) · Transfusion · doi:10.1111/j.1537-2995.2006.01026.x · Cited by 577
Fergusson, D. A., Hébert, P., Hogan, D. L., LeBel, L., Rouvinez-Bouali, N., Smyth, J. A., Sankaran, K., Tinmouth, A., Blajchman, M. A., Kovacs, L., et al. (2012) · JAMA · doi:10.1001/2012.jama.11953 · Cited by 440
Metadata
- Authors
- Ho, J., Sibbald, W. J., & Chin-Yee, I. H.
- Venue
- Critical Care Medicine
- Published
- 2003-12
- Volume
- 31
- Issue
- Supplement
- Pages
- S687-S697
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W2093362111
- Cited by
- 254
- References
- 74
- FWCI
- 5.89
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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