CoChat
Sign Up
Cited by 31Malaria Research and ControlHemoglobinopathies and Related DisordersErythrocyte Function and Pathophysiology

The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Modulation of malaria virulence by determinants of Plasmodium falciparum erythrocyte membrane protein-1 display

Fairhurst, Rick M, Wellems, Thomas E·2006·Current Opinion in Hematology
DOI 10.1097/01.moh.0000219655.73162.42
Open this paper in CoChat — free account

Abstract

PURPOSE OF REVIEW: Plasmodium falciparum malaria parasites carry approximately 60 var genes that encode variable adhesins termed P. falciparum erythrocyte membrane protein-1. Clonal expression of a single P. falciparum erythrocyte membrane protein-1 variant on the surface of the parasitized host erythrocyte promotes binding of the cell to blood elements (including noninfected erythrocytes, leukocytes) and walls of microvessels. These binding events enable parasitized erythrocytes to sequester and avoid clearance by the spleen, and they also contribute to disease by causing microvascular inflammation and obstruction. RECENT FINDINGS: Steps by which P. falciparum erythrocyte membrane protein-1 is exported to the parasitized erythrocyte surface have recently been elucidated. The ability of parasites to cytoadhere and cause disease depends on the variant of P. falciparum erythrocyte membrane protein-1 as well as its amount and distribution at the erythrocyte surface. An example of a host polymorphism that affects P. falciparum erythrocyte membrane protein-1 display is hemoglobin C, which may protect against malaria by impairing the parasite's ability to adhere to microvessels and induce inflammation. Interference with P. falciparum erythrocyte membrane protein-1-mediated phenomena appears to diminish cytoadherence in vivo and to protect against disease in animal models. SUMMARY: Plasmodium falciparum erythrocyte membrane protein-1-mediated sequestration of parasitized erythrocytes plays a central role in malaria pathogenesis. Clinical interventions aimed at reducing cytoadherence and microvascular inflammation may improve disease outcome.

Overview

Integrity signals

Registry

Crossref · 10.1097/01.moh.0000219655.73162.42

Cites

4 of 4 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • P. falciparum infected erythrocytes sequester in the placenta by expressing surface antigens, mainly VAR2CSA, that bind to chondroitin sulphate A.

    “P. falciparum infected erythrocytes sequester in the placenta by expressing surface antigens, mainly variant surface antigen (VAR2CSA), that bind to specific receptors, mainly chondroitin sulphate A.”

    From Malaria in pregnancy. (2013) · cites this paper as [63]

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 56

  1. Baruch, 1995, Cell, 82, 77, 10.1016/0092-8674(95)90054-3 · DOI
  2. Smith, 1995, Cell, 82, 101, 10.1016/0092-8674(95)90056-X · DOI · Paper page
  3. Rowe, 2004, Mol Microbiol, 53, 1011, 10.1111/j.1365-2958.2004.04256.x · DOI
  4. Flick, 2004, Mol Biochem Parasitol, 134, 3, 10.1016/j.molbiopara.2003.09.010 · DOI
  5. Miller, 2002, Nature, 415, 673, 10.1038/415673a · DOI
  6. David, 1983, Proc Natl Acad Sci U S A, 80, 5075, 10.1073/pnas.80.16.5075 · DOI
  7. Chotivanich, 2002, J Infect Dis, 185, 1538, 10.1086/340213 · DOI
  8. Silamut, 1999, Am J Pathol, 155, 395, 10.1016/S0002-9440(10)65136-X · DOI
  9. Pongponratn, 2003, Am J Trop Med Hyg, 69, 345, 10.4269/ajtmh.2003.69.345 · DOI
  10. Taylor, 2004, Nat Med, 10, 143, 10.1038/nm986 · DOI
  11. Turner, 1994, Am J Pathol, 145, 1057
  12. Armah, 2005, Ann Trop Med Parasitol, 99, 629, 10.1179/136485905X51508 · DOI
  13. Dondorp, 2005, PLoS Med, 2, e204, 10.1371/journal.pmed.0020204 · DOI
  14. Raventos-Suarez, 1985, Proc Natl Acad Sci U S A, 82, 3829, 10.1073/pnas.82.11.3829 · DOI
  15. Langreth, 1985, Infect Immun, 47, 760, 10.1128/IAI.47.3.760-766.1985 · DOI
  16. Pongponratn, 2000, Southeast Asian J Trop Med Public Health, 31, 829
  17. Cooke, 2002, Methods Mol Med, 72, 561
  18. Pologe, 1986, Nature, 322, 474, 10.1038/322474a0 · DOI
  19. Crabb, 1997, Cell, 89, 287, 10.1016/S0092-8674(00)80207-X · DOI
  20. Waterkeyn, 2000, EMBO J, 19, 2813, 10.1093/emboj/19.12.2813 · DOI
  21. Waller, 1999, J Biol Chem, 274, 23808, 10.1074/jbc.274.34.23808 · DOI
  22. Oh, 2000, Mol Biochem Parasitol, 108, 237, 10.1016/S0166-6851(00)00227-9 · DOI
  23. Waller, 2002, Mol Biochem Parasitol, 119, 125, 10.1016/S0166-6851(01)00395-4 · DOI
  24. Pasloske, 1993, Mol Biochem Parasitol, 59, 59, 10.1016/0166-6851(93)90007-K · DOI
  25. Horrocks, 2005, J Cell Sci, 118, 2507, 10.1242/jcs.02381 · DOI
  26. Wickham, 2001, EMBO J, 20, 5636, 10.1093/emboj/20.20.5636 · DOI
  27. Lopez-Estrano, 2003, Proc Natl Acad Sci U S A, 100, 12402, 10.1073/pnas.2133080100 · DOI
  28. Papakrivos, 2005, Mol Microbiol, 55, 1272, 10.1111/j.1365-2958.2004.04468.x · DOI
  29. Trelka, 2000, Mol Biochem Parasitol, 106, 131, 10.1016/S0166-6851(99)00207-8 · DOI
  30. Marti, 2004, Science, 306, 1930, 10.1126/science.1102452 · DOI
  31. Hiller, 2004, Science, 306, 1934, 10.1126/science.1102737 · DOI
  32. Kriek, 2003, Mol Microbiol, 50, 1215, 10.1046/j.1365-2958.2003.03784.x · DOI
  33. Knuepfer, 2005, Blood, 105, 4078, 10.1182/blood-2004-12-4666 · DOI
  34. Haeggstrom, 2004, Mol Biochem Parasitol, 133, 1, 10.1016/j.molbiopara.2003.07.006 · DOI
  35. Udomsangpetch, 2002, Proc Natl Acad Sci U S A, 99, 11825, 10.1073/pnas.172398999 · DOI
  36. Allred, 1986, J Cell Sci, 81, 1, 10.1242/jcs.81.1.1 · DOI
  37. Albano, 1999, Eur J Cell Biol, 78, 453, 10.1016/S0171-9335(99)80072-7 · DOI
  38. Adisa, 2001, J Cell Sci, 114, 3377, 10.1242/jcs.114.18.3377 · DOI
  39. Williams, 2005, PLoS Med, 2, e128, 10.1371/journal.pmed.0020128 · DOI
  40. Cappadoro, 1998, Blood, 92, 2527, 10.1182/blood.V92.7.2527 · DOI · Paper page
  41. Ayi, 2004, Blood, 104, 3364, 10.1182/blood-2003-11-3820 · DOI
  42. Genton, 1995, Nature, 378, 564, 10.1038/378564a0 · DOI
  43. Allen, 1999, Am J Trop Med Hyg, 60, 1056, 10.4269/ajtmh.1999.60.1056 · DOI
  44. Cortes, 2005, Mol Biochem Parasitol, 142, 252, 10.1016/j.molbiopara.2005.03.016 · DOI
  45. Agarwal, 2000, Blood, 96, 2358, 10.1182/blood.V96.7.2358 · DOI
  46. Mockenhaupt, 2004, J Infect Dis, 190, 1006, 10.1086/422847 · DOI
  47. Rihet, 2004, Hum Mol Genet, 13, 1, 10.1093/hmg/ddh002 · DOI
  48. Fairhurst, 2005, Nature, 435, 1117, 10.1038/nature03631 · DOI
  49. Rowe, 1995, Infect Immun, 63, 2323, 10.1128/IAI.63.6.2323-2326.1995 · DOI
  50. Fairhurst, 2003, Blood, 101, 3309, 10.1182/blood-2002-10-3105 · DOI
  51. Arie, 2005, J Struct Biol, 150, 163, 10.1016/j.jsb.2005.02.008 · DOI
  52. Tokumasu, 2005, J Cell Sci, 118, 1091, 10.1242/jcs.01662 · DOI
  53. Baruch, 2002, Proc Natl Acad Sci USA, 99, 3860, 10.1073/pnas.022018399 · DOI
  54. Chen, 2004, Vaccine, 22, 2701, 10.1016/j.vaccine.2004.02.015 · DOI
  55. Yipp, 2003, Blood, 101, 331, 10.1182/blood-2002-06-1725 · DOI
  56. Wassmer, 2005, PLoS Med, 2, e245, 10.1371/journal.pmed.0020245 · DOI

Cited by

Sorted by citations

Metadata

Authors
Fairhurst, R. M., & Wellems, T. E.
Affiliations
National Institutes of Health (US)
Corresponding author
Wellems, Thomas E
ORCID
Wellems, Thomas E
Venue
Current Opinion in Hematology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2006-05
Volume
13
Issue
3
Pages
124-130
ISSN
1065-6251 (ISSN-L)
DOI
10.1097/01.moh.0000219655.73162.42
OpenAlex
W2117603008
Cited by
31
References
4
Citations by year
2026: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 1 · 2020: 3 · 2017: 1 · 2014: 1 · 2013: 4 · 2012: 3
FWCI
0.35
Type
journal article
Language
en
Open access
closed
Locations
  • Current Opinion in Hematology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
  • Health Sciences › Medicine › Genetics (clinical) › Hemoglobinopathies and Related Disorders
  • Health Sciences › Medicine › Physiology (medical) › Erythrocyte Function and Pathophysiology
Keywords
Plasmodium falciparum, erythrocyte membrane protein 1, var genes, cytoadherence, sequestration, malaria virulence, hemoglobin C, microvascular inflammation, malaria pathogenesis
MeSH terms
Animals, Cell Adhesion, Erythrocytes, Hemoglobin C, Humans, Malaria, Plasmodium falciparum, Virulence, Protozoan Proteins, Protein Transport

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review