Antisense Therapy for ALS Found Safe in Small Trial, but More Safety Data Are Sought
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Each is checked against this paper’s own text: does it say what the citing paper says it does?
Two major problems associated with ASOs are the high doses required to achieve gene silencing effects and immunostimulatory effects.
“However, two major problems associated with ASOs are the high doses required to achieve gene silencing effects and immunostimulatory effects.26,27”
From Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain (2013) · cites this paper as [27]
A number of clinical trials are now in progress for treatments of serious neurological diseases that rely on continuous infusion of ASOs into the CSF.
“Furthermore, a number of clinical trials are now in progress for treatments of serious neurological diseases that rely on continuous infusion of ASOs into the CSF.27,28”
From Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain (2013) · cites this paper as [27]
Cited by
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Lipid Nanoparticle Delivery of siRNA to Silence Neuronal Gene Expression in the Brain
Rungta, R. L., Choi, H. B., Lin, P. J., Ko, R. W., Ashby, D., Nair, J., Manoharan, M., Cullis, P. R., & MacVicar, B. A. (2013) · Molecular Therapy—Nucleic Acids · doi:10.1038/mtna.2013.65 · Cited by 165 · see citing works
- Authors
- Robinson, R.
- Corresponding author
- Robinson, Richard
- ORCID
- Robinson, Richard
- Venue
- Neurology Today
- Published
- 2012-06-21
- Volume
- 12
- Issue
- 12
- Pages
- 4-5
- ISSN
- 1533-7006 (ISSN-L)
- 1548-7822
- OpenAlex
- W2791163517
- Cited by
- 2
- References
- 0
- Citations by year
- 2014: 1 · 2013: 1
- FWCI
- 0.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology Today (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Genetics › Neurogenetic and Muscular Disorders Research
- Keywords
- amyotrophic lateral sclerosis, antisense therapy, gene silencing, drug safety, small clinical trials
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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